Behavioural Intervention
Communication Intervention for Dementia
Recruiting1 award12 criteria
Seattle, Washington
This trial is testing whether or not the Jumpstart intervention can improve patient-centered outcomes for those with chronic illness. The study will specifically look at Alzheimer's disease and related dementias, but will also include other common chronic illnesses. The trial will assess the efficacy of the intervention by measuring quality of care, intensity of care outcomes, and patient- and family-reported outcomes. There will also be a mixed-methods evaluation of the implementation of the intervention to explore barriers and facilitators to future implementation and dissemination.
Behavioural Intervention
Function Focused Care for Dementia
Recruiting0 awards4 criteria
Baltimore, Maryland
This trial is testing the efficacy of a new approach to care for older adults with Alzheimer's Disease and Related Dementias (ADRD) that encourages physical activity during hospitalization. The new approach, called Function Focused Care for Acute Care (FFC-AC-EIT), is being tested against standard care (Function Focused Care Education Only, or EO) in 12 hospitals. The primary outcomes being measured are physical activity, function, and participation in function focused care.
Behavioral Intervention
Cognitive Training for Mild Cognitive Impairment
Recruiting1 award10 criteria
San Francisco, California
This trial is designed to find the best combination of cognitive training exercises to improve cognitive function in older adults with mild cognitive impairment, and to reduce the risk of dementia.
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Trials for Alzheimer's Disease Patients
Behavioural Intervention
Dysphagia Therapy for Alzheimer's Disease
Recruiting1 award
Madison, Wisconsin
This trial tests a saliva gel and tongue exercises to help people with Alzheimer's who have trouble swallowing. These patients are at risk of pneumonia because they can't swallow well. The saliva gel keeps their mouth moist, and the exercises make their tongue stronger to help with swallowing.
Trials for Mild Cognitive Impairment Patients
Tyrosine Kinase Inhibitor
TKIs for Dementia
Recruiting2 awardsPhase 1
Santa Monica, California
This trial is designed to evaluate the tolerability and potential efficacy of tyrosine kinase inhibitors in patients with mild cognitive impairment or dementia. Baseline and outcome measures utilize validated tests that are appropriate for repeated measures. The study population is sufficiently broad and the conditions of interest are sufficiently prevalent so that recruitment of the projected numbers of subjects is not a limiting factor.
Phase 3 Trials
Monoclonal Antibodies
Investigational Alzheimer's Drugs for Early Onset Alzheimer's Disease
Recruiting0 awardsPhase 2 & 3
Birmingham, Alabama
This trial tests two drugs, lecanemab and E2814, in people with a genetic mutation that causes Alzheimer's disease. Lecanemab helps remove harmful protein clumps from the brain, while E2814 prevents harmful protein tangles from forming. The goal is to see if these drugs can slow down or improve symptoms of Alzheimer's.
Monoclonal Antibodies
Gantenerumab for Alzheimer's Disease
Recruiting0 awardsPhase 2 & 3
Birmingham, Alabama
This trial will study if treatment with an investigational study drug can prevent or slow the rate of Alzheimer's disease (AD)-causing accumulation of amyloid beta (Aβ). Part 1 will use Aβ positron emission tomography (PET) imaging to determine if treatment with the study drug prevents or slows the rate of Aβ pathological disease accumulation. Part 2 will evaluate the effect of early Aβ plaque reduction/prevention on disease progression by assessing downstream non-Aβ biomarkers of AD.
Behavioural Intervention
Hearing Aid Intervention for Cognitive Decline
Recruiting2 awardsPhase 3
Hagerstown, Maryland
This trial is testing if giving hearing aids to older adults with untreated hearing loss can help slow down memory and thinking problems. It compares this to just giving general health advice. The idea is that better hearing keeps the brain active, which might help prevent cognitive decline. Hearing aids have been shown to improve cognitive function and offset declines in neural function in older adults.
Monoclonal Antibodies
Donanemab for Early Alzheimer's Disease
Recruiting1 awardPhase 3
Chandler, Arizona
This trial is testing different doses of donanemab, a drug aimed at helping people with early Alzheimer's disease. Donanemab has shown rapid reduction of brain amyloid in early Alzheimer's disease. The study will look at how often and how severely participants experience a side effect involving brain swelling. Researchers also want to find out which patient characteristics might predict this side effect.
Trials With No Placebo
Behavioural Intervention
Dysphagia Therapy for Alzheimer's Disease
Recruiting1 award
Madison, Wisconsin
This trial tests a saliva gel and tongue exercises to help people with Alzheimer's who have trouble swallowing. These patients are at risk of pneumonia because they can't swallow well. The saliva gel keeps their mouth moist, and the exercises make their tongue stronger to help with swallowing.
Tyrosine Kinase Inhibitor
TKIs for Dementia
Recruiting2 awardsPhase 1
Santa Monica, California
This trial is designed to evaluate the tolerability and potential efficacy of tyrosine kinase inhibitors in patients with mild cognitive impairment or dementia. Baseline and outcome measures utilize validated tests that are appropriate for repeated measures. The study population is sufficiently broad and the conditions of interest are sufficiently prevalent so that recruitment of the projected numbers of subjects is not a limiting factor.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.