Tensilon

curare overdosage, gallamine triethiodide, curare + 8 more

Treatment

12 FDA approvals

18 Active Studies for Tensilon

Treatment for

curare overdosage

What is Tensilon

EdrophoniumThe Generic name of this drug

Treatment SummaryEdrophonium chloride is a drug used to treat irregular heart rhythms and diagnose myasthenia gravis, a rare muscle disorder. It can also be used as an antidote for drugs that block nerve signals, such as curare. Edrophonium chloride works quickly and its effects don't last long.

Enlon Plusis the brand name

image of different drug pills on a surface

Tensilon Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Enlon Plus

Edrophonium

1991

Approved as Treatment by the FDA

Edrophonium, otherwise known as Enlon Plus, is approved by the FDA for 12 uses such as Myasthenia Gravis and Respiratory Insufficiency .

Myasthenia Gravis

Respiratory Insufficiency

Used to treat Respiratory Depression in combination with Atropine

curare overdose

Used to treat curare overdose in combination with Atropine

tubocurarine

Myasthenia Gravis

Neuromuscular Blocking Agents

Used to treat nondepolarizing blocking agents in combination with Atropine

Neuromuscular Blockade

acetone

non-depolarizing neuromuscular blocking agents

gallamine triethiodide

curare overdosage

curare

Effectiveness

How Tensilon Affects PatientsEdrophonium is a fast-acting medicine that helps to temporarily improve muscle movement. It works by blocking the breakdown of a chemical found in the body called acetylcholine, allowing for more acetylcholine to be available at the sites where it is needed. This is especially useful in people with myasthenia gravis, a condition where the body's immune system attacks some of the body's nerve receptors. By increasing the amount of acetylcholine, edrophonium chloride can help the remaining receptors to work more effectively. The effects can be seen within 30 to 60 seconds and last for about 10 minutes.

How Tensilon works in the bodyEdrophonium helps your body make the most of its natural acetylcholine. It does this by blocking the enzyme that normally breaks down acetylcholine. When acetylcholine is able to stay active for longer, it can stimulate two types of receptors that affect many parts of the body.

When to interrupt dosage

The amount of Tensilon is contingent upon the diagnosed affliction, including Neuromuscular Blocking Agents, non-depolarizing neuromuscular blocking agents and Neuromuscular Blockade. The magnitude of dosage varies, based on the form of delivery (e.g. Injection, solution or Intramuscular; Intravenous) outlined in the table beneath.

Condition

Dosage

Administration

non-depolarizing neuromuscular blocking agents

10.0 mg/mL,

, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous

gallamine triethiodide

10.0 mg/mL,

Neuromuscular Blocking Agents

10.0 mg/mL,

curare

10.0 mg/mL,

tubocurarine

10.0 mg/mL,

curare overdose

10.0 mg/mL,

Neuromuscular Blockade

10.0 mg/mL,

Myasthenia Gravis

10.0 mg/mL,

Respiratory Insufficiency

10.0 mg/mL,

acetone

10.0 mg/mL,

curare overdosage

10.0 mg/mL,

Warnings

There are 20 known major drug interactions with Tensilon.

Common Tensilon Drug Interactions

Drug Name

Risk Level

Description

Abacavir

Minor

Edrophonium may decrease the excretion rate of Abacavir which could result in a higher serum level.

Acetylcholine

Minor

The risk or severity of adverse effects can be increased when Edrophonium is combined with Acetylcholine.

Acrivastine

Minor

Edrophonium may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Agmatine

Minor

The therapeutic efficacy of Agmatine can be decreased when used in combination with Edrophonium.

Albutrepenonacog alfa

Minor

Edrophonium may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Tensilon Toxicity & Overdose RiskTaking too much of this type of drug can lead to cholinergic crisis, in which a person may experience nausea, vomiting, diarrhea, sweating, increased mucus production, and slow heart rate.

image of a doctor in a lab doing drug, clinical research

Tensilon Novel Uses: Which Conditions Have a Clinical Trial Featuring Tensilon?

36 active investigations are being conducted to analyze the potential of Tensilon to address curare, Respiratory Depression and gallamine triethiodide.

Condition

Clinical Trials

Trial Phases

curare overdosage

0 Actively Recruiting

curare

0 Actively Recruiting

Neuromuscular Blockade

1 Actively Recruiting

Not Applicable

gallamine triethiodide

0 Actively Recruiting

Myasthenia Gravis

17 Actively Recruiting

Phase 2, Phase 3, Phase 1, Not Applicable

tubocurarine

0 Actively Recruiting

non-depolarizing neuromuscular blocking agents

0 Actively Recruiting

Respiratory Insufficiency

0 Actively Recruiting

Neuromuscular Blocking Agents

0 Actively Recruiting

curare overdose

0 Actively Recruiting

acetone

0 Actively Recruiting

Tensilon Reviews: What are patients saying about Tensilon?

1Patient Review

4/3/2009

Tensilon for Diagnostic Test for Myasthenia Gravis

Bay Regional Medical Center in Michigan did not have Tensilon available. I'm curious if anyone knows of a place where this medication can be found or what is being used in its stead.

Patient Q&A Section about tensilon

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the purpose of Tensilon?

"The Tensilon test is a way for doctors to diagnose myasthenia gravis. Tensilon is a drug that prevents the breakdown of a chemical called acetylcholine. This chemical is important because it helps to stimulate your muscles."

Answered by AI

Is Edrophonium the same as Tensilon?

"The Tensilon test is a quick way to diagnose myasthenia gravis, an autoimmune disease in which the body produces antibodies against acetylcholine receptor proteins.

An Edrophonium test is when a doctor gives a patient a drug that slows the breakdown of acetylcholine. This test is used to help diagnose myasthenia gravis, an autoimmune disease that causes the body to produce antibodies against acetylcholine receptor proteins."

Answered by AI

Is Tensilon still used?

"The Tensilon test has been used to help diagnose MG since the 1930s, but because of the high number of false positives, the U.S. Food and Drug Administration discontinued the use of the drug in 2018. It is no longer used in the U.S. and many other countries."

Answered by AI

How does the Tensilon test work?

"The Tensilon test is a diagnostic test used to evaluate myasthenia gravis, which is a neuromuscular condition characterized by muscle weakness. The test involves an injection of Tensilon (edrophonium) after which your muscle strength is evaluated to determine whether your weakness is caused by myasthenia gravis or not."

Answered by AI

Clinical Trials for Tensilon

Have you considered Tensilon clinical trials? We made a collection of clinical trials featuring Tensilon, we think they might fit your search criteria.

Have you considered Tensilon clinical trials? We made a collection of clinical trials featuring Tensilon, we think they might fit your search criteria.