Tobradex St

Pemphigus, Macular Edema, Iridocyclitis + 102 more

Treatment

106 FDA approvals

20 Active Studies for Tobradex St

Treatment for

Pemphigus

What is Tobradex St

DexamethasoneThe Generic name of this drug

Treatment SummaryTobramycin is an antibiotic drug used to treat a wide range of infections caused by both gram-positive and gram-negative bacteria. It is most commonly used to treat chronic Pseudomonas aeruginosa infections in cystic fibrosis patients. Tobramycin can be taken by inhalation, injection, or applied externally to the eye. The drug, which was approved by the FDA in 1975, has some potential side effects such as nephrotoxicity and ototoxicity, but is still a valuable option in the face of antibiotic resistance.

Decadronis the brand name

image of different drug pills on a surface

Tobradex St Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Decadron

Dexamethasone

1958

452

Approved as Treatment by the FDA

Dexamethasone, also known as Decadron, is approved by the FDA for 106 uses which include Choroiditis and Drug Allergy .

Choroiditis

Helps manage Choroiditis

Drug Allergy

Helps manage Drug hypersensitivity reaction

Seborrheic dermatitis

Helps manage Severe Seborrheic Dermatitis

Berylliosis

Helps manage Berylliosis

Ankylosing Spondylitis

Helps manage Ankylosing Spondylitis (AS)

Lymphoma, Non-Hodgkin

Helps manage Malignant Lymphomas

Crohn Disease

Helps manage Regional Enteritis

Lupus

Helps manage Systemic Lupus Erythematosus (SLE)

Arthritis, Gouty

Helps manage Acute Gouty Arthritis

Multiple Myeloma

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Rhinitis, Allergic

Helps manage Perennial Allergic Rhinitis (PAR)

Hay Fever

Helps manage Seasonal Allergic Rhinitis

Mycosis Fungoides

Helps manage Mycosis Fungoides (MF)

Conjunctivitis

Helps manage anterior eye segment inflammation

Tennis Elbow

Helps manage Epicondylitis

Degenerative polyarthritis

Helps manage Posttraumatic Osteoarthritis

Bursitis

Helps manage Bursitis

Cushing Syndrome

Anemia, Hemolytic

Helps manage acquired immune hemolytic anemia

Congenital adrenal hyperplasia

Helps manage Congenital Adrenal Hyperplasia (CAH)

Optic Neuritis

Helps manage Optic Neuritis

Adrenal Insufficiency

Helps manage Adrenal cortical hypofunctions

Ulcerative Colitis

Helps manage Ulcerative Colitis

Adrenocortical Hyperfunction

Inflammation

Congenital Hypoplastic Anemia

Helps manage Congenital Hypoplastic Anemia

Asthma

Helps manage Asthma

Erythroblastopenia

Helps manage Erythroblastopenia

Hypercalcemia

Helps manage Hypercalcemia

Rheumatoid Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Aspiration Pneumonitis

Helps manage Aspiration Pneumonitis

Acute Leukemia (Category)

Helps manage Acute Leukemia (Category)

Tuberculosis (TB)

Helps manage Tuberculosis (TB)

anterior eye segment inflammation

Helps manage anterior eye segment inflammation

Mycosis Fungoides (MF)

Helps manage Mycosis Fungoides (MF)

Choroiditis

Helps manage Choroiditis

Tenosynovitis

Helps manage Tenosynovitis

Epicondylitis

Helps manage Epicondylitis

Cancer

Helps manage Cancer

Keratitis

Helps manage Keratitis

Trichinosis

Helps manage Trichinosis

Multiple Myeloma (MM)

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Perennial Allergic Rhinitis (PAR)

Helps manage Perennial Allergic Rhinitis (PAR)

Adrenal Gland Hyperfunction

Seasonal Allergic Rhinitis

Helps manage Seasonal Allergic Rhinitis

Adrenal cortical hypofunctions

Helps manage Adrenal cortical hypofunctions

Iridocyclitis

Helps manage Iridocyclitis

Cushing's Syndrome

Immune Thrombocytopenia (ITP)

Helps manage Immune Thrombocytopenia (ITP)

Serum Sickness

Helps manage Serum Sickness

Berylliosis

Helps manage Berylliosis

acquired immune hemolytic anemia

Helps manage acquired immune hemolytic anemia

Secondary thrombocytopenia

Helps manage Secondary thrombocytopenia

Regional Enteritis

Helps manage Regional Enteritis

severe Psoriasis

Helps manage severe Psoriasis

Synovitis

Helps manage Synovitis

Acute Coryza

Helps manage acute rheumatic carditis

Drug hypersensitivity reaction

Helps manage Drug hypersensitivity reaction

Edema of the cerebrum

Helps manage Edema of the cerebrum

Rheumatoid Arthritis

Helps manage Rheumatoid Arthritis

Atopic Dermatitis

Helps manage Atopic Dermatitis

Severe Seborrheic Dermatitis

Helps manage Severe Seborrheic Dermatitis

Malignant Lymphomas

Helps manage Malignant Lymphomas

exfoliative erythroderma

Helps manage exfoliative erythroderma

Systemic Lupus Erythematosus (SLE)

Helps manage Systemic Lupus Erythematosus (SLE)

Optic Neuritis

Helps manage Optic Neuritis

Synovitis

Helps manage Synovitis

Congenital Adrenal Hyperplasia (CAH)

Helps manage Congenital Adrenal Hyperplasia (CAH)

Bursitis

Helps manage Bursitis

Ankylosing Spondylitis (AS)

Helps manage Ankylosing Spondylitis (AS)

Sarcoidosis

Helps manage Sarcoidosis

Uveitis

Helps manage Uveitis

Chorioretinitis

Helps manage Chorioretinitis

Ophthalmia, Sympathetic

Helps manage Ophthalmia, Sympathetic

non-suppurative Thyroiditis

Helps manage non-suppurative Thyroiditis

Contact Dermatitis

Helps manage Contact Dermatitis

Tuberculosis

Helps manage Tuberculosis (TB)

Loeffler's syndrome

Helps manage Loeffler's syndrome

Pemphigus

Helps manage Pemphigus

Uveitis

Helps manage Uveitis

Iritis

Helps manage Iritis

Acute Gouty Arthritis

Helps manage Acute Gouty Arthritis

Hypercalcemia

Helps manage Hypercalcemia

Asthma

Helps manage Asthma

Rosacea

Helps manage Rosacea

Posttraumatic Osteoarthritis

Helps manage Posttraumatic Osteoarthritis

Brain

Helps manage Edema of the cerebrum

Inflammation

Iridocyclitis

Helps manage Iridocyclitis

Stevens-Johnson Syndrome

Helps manage Stevens-Johnson Syndrome

Ulcerative Colitis

Helps manage Ulcerative Colitis

Iritis

Helps manage Iritis

Pulmonary Eosinophilia

Helps manage Loeffler's syndrome

Allergic Conjunctivitis (AC)

Helps manage Allergic Conjunctivitis (AC)

Anemia, Diamond-Blackfan

Helps manage Congenital Hypoplastic Anemia

Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Acute Myeloid Leukemia (AML)

Helps manage Acute Leukemia (Category)

varicella-zoster virus acute retinal necrosis

Helps manage varicella-zoster virus acute retinal necrosis

Rosacea

Helps manage Rosacea

Multiple Myeloma

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Bullous dermatitis herpetiformis

Helps manage Bullous dermatitis herpetiformis

Thrombocytopenia

Helps manage Secondary thrombocytopenia

Pemphigus

Helps manage Pemphigus

Thyroiditis

Helps manage non-suppurative Thyroiditis

Psoriasis

Helps manage severe Psoriasis

Effectiveness

How Tobradex St Affects PatientsTobramycin is an antibiotic that has a wide range of activity against certain bacteria. It is taken up by cells in the kidney and ear, which can cause damage to these areas and lead to side effects like hearing loss, kidney damage, and muscle weakness. It can also cross the placenta, potentially leading to deafness in babies born to mothers who took it during pregnancy. All forms of tobramycin can also cause allergic reactions, including severe skin reactions like Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

How Tobradex St works in the bodyTobramycin is an antibiotic that kills certain bacteria. It works by binding to the bacterial cells and allowing more of the drug to enter the cell. This increases the permeability of the cell's membrane and causes it to break down. Inside the cell, tobramycin stops the cell from making proteins, which stops the bacteria from reproducing. Bacteria can develop a resistance to tobramycin by making changes to their proteins, or by making changes to tobramycin itself. Tobramycin is not effective against anaerobic bacteria.

When to interrupt dosage

The recommended amount of Tobradex St is contingent upon the diagnosed condition, such as Cystic Fibrosis (CF), steroid-responsive inflammation and Bacterial Meningitis. The quantity of dosage is contingent on the approach of administration as stated in the table below.

Condition

Dosage

Administration

Chorioretinitis

, 0.7 mg, 0.001 mg/mg, 10.0 mg/mL, 4.0 mg/mL, 1.5 mg, 1.0 mg/mL, 4.0 mg, 0.75 mg, 1.0 mg, 2.0 mg, 6.0 mg, 0.5 mg, 0.5 mg/mL, 0.1 %, 40.0 mg, 0.0005 mg/mg, 517.0 mg/mL, 0.0015 mg/mg, 0.4 mg, 20.0 mg, 0.1 mg/mL, 0.5 mg/units

, Implant, Implant - Intravitreal, Intravitreal, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Injection, solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Suspension / drops, Solution, Solution - Ophthalmic, Auricular (otic), Suspension - Auricular (otic), Intramuscular, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Injection, Intra-articular; Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Elixir, Elixir - Oral, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intrasynovial; Intravenous, Liquid - Intramuscular; Intrasynovial; Intravenous, Liquid - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Auricular (otic); Ophthalmic, Solution / drops - Auricular (otic); Ophthalmic, Solution - Intramuscular; Intrasynovial; Intravenous, Solution - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intramuscular; Intravenous, Topical, Solution / drops - Topical, Ophthalmic; Topical, Liquid - Ophthalmic; Topical, Ointment - Topical, Liquid - Auricular (otic); Ophthalmic, Ointment - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Solution - Intramuscular; Intravenous, Liquid - Intra-articular; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Oral, Suspension / drops - Auricular (otic), Injection - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Dental, Liquid - Dental, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Epidural; Infiltration; Intramuscular; Intravenous, Injection - Intramuscular, Solution - Parenteral, Parenteral, Injection, solution - Ophthalmic, Intraocular, Injection, solution - Intraocular, Injection, suspension, Injection, suspension - Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Intramuscular; Intravenous; Topical, Kit - Intramuscular; Intravenous; Topical, Injection, emulsion, Injection, emulsion - Intramuscular; Intravenous, Insert, Insert - Ophthalmic, Solution - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Perineural, Suspension / drops - Topical

Stevens-Johnson Syndrome

Ophthalmia, Sympathetic

Scleritis

Iritis

Sarcoidosis

Berylliosis

Hypercalcemia

Otitis Externa

Infection

Otitis Media

Necrobiosis Lipoidica

Uveitis

Seborrheic dermatitis

Ocular Infections, Irritations and Inflammations

Aspiration Pneumonitis

Keloids Scars

Communicable Diseases

Bacterial Infections

Communicable Diseases

Warnings

Tobradex St Contraindications

Condition

Risk Level

Notes

active periocular infections

Do Not Combine

Eye

Do Not Combine

Tympanic membrane structure

Do Not Combine

suspected periocular infections

Do Not Combine

Eye Infections, Fungal

Do Not Combine

Viral Conjunctivitis

Do Not Combine

Communicable Diseases

Do Not Combine

Eye Infection

Do Not Combine

Mycoses

Do Not Combine

Chickenpox

Do Not Combine

External auditory canal structure

Do Not Combine

epithelial herpes simplex keratitis

Do Not Combine

External Ear

Do Not Combine

torn posterior lens

Do Not Combine

Open-angle glaucoma

Do Not Combine

Cornea

Do Not Combine

Eye Infections

Do Not Combine

ruptured posterior lens

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Dexamethasone may interact with Pulse Frequency

There are 20 known major drug interactions with Tobradex St.

Common Tobradex St Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Dexamethasone.

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Dexamethasone is combined with 2-Methoxyethanol.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Dexamethasone.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Dexamethasone.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Dexamethasone.

Tobradex St Toxicity & Overdose RiskTobramycin can be dangerous in large doses and may lead to kidney damage, hearing loss, nerve or muscle problems, and difficulty breathing. If someone overdoses, symptomatic and supportive treatments should be administered and dialysis may help remove the drug from the body. Fortunately, it is very difficult to overdose on tobramycin due to poor absorption in the digestive tract. Animal studies have found that the lethal dose for mice and rats ranges from 367-1030 mg/kg when given through injections, but it is greater than 7500 mg/kg when taken orally.

image of a doctor in a lab doing drug, clinical research

Tobradex St Novel Uses: Which Conditions Have a Clinical Trial Featuring Tobradex St?

Currently, 8 active trials are in progress to assess the efficacy of Tobradex St in treating Cystic Fibrosis, Ocular Bacterial Infections and Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Thyroiditis

0 Actively Recruiting

Lupus

63 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Acute Coryza

0 Actively Recruiting

Inflammation

58 Actively Recruiting

Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4

Tuberculosis

2 Actively Recruiting

Phase 3, Phase 2

Pulmonary Eosinophilia

8 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 1

Open-angle glaucoma

45 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1, Phase 1

Uveitis

3 Actively Recruiting

Not Applicable, Phase 3

Asthma

92 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3

Rheumatoid Arthritis

53 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Rosacea

2 Actively Recruiting

Early Phase 1, Phase 2

Acute Myeloid Leukemia (AML)

32 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3

Diabetic Macular Edema

20 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1

Thrombocytopenia

0 Actively Recruiting

Arthritis, Juvenile

1 Actively Recruiting

Not Applicable

Bacterial Infections

0 Actively Recruiting

Atopic Dermatitis

10 Actively Recruiting

Phase 2, Phase 3, Phase 4

Skin Diseases

0 Actively Recruiting

Trichinosis

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

Tobradex St Reviews: What are patients saying about Tobradex St?

5Patient Review

6/13/2012

Tobradex St for Inflammation of the Eye

I had an allergic reaction in my eyes and went to the doctor. He prescribed me this medication along with Pataday. I have to say, both of them together really worked well for me and I'm feeling 100% better now.

4.7Patient Review

3/5/2012

Tobradex St for Severe Inflammation of the Cornea with Rosacea Involvement

This treatment provides temporary relief from the sensation of heat in my eye.

4.7Patient Review

11/15/2011

Tobradex St for Inflammation of the Front Portion of the Eye

After using this drop for about a week, my eyelid drooped. My doctor acted like it was no big deal and said there's nothing that can be done about it. Predforte has worked for me for almost 20 years with no problems, so I'll stick to that instead.

4.3Patient Review

3/23/2012

Tobradex St for Allergic Conjunctivitis

This treatment is effectively getting rid of my staph infection, but the drowsiness side effect is really extreme. I've fallen asleep during church service and movies before, which is really embarrassing. Has anyone else experienced this side effect?

4Patient Review

1/18/2013

Tobradex St for Scratch Wound on Cornea

There were some mild side effects, like redness and swelling, but they weren't enough to outweigh the benefits. Just be sure to read the directions carefully!

2.3Patient Review

1/1/2013

Tobradex St for Allergic Conjunctivitis

Unfortunately, I had an allergic reaction to this medication.

1Patient Review

7/23/2011

Tobradex St for Inflammation of the Front Portion of the Eye

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tobradex st

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Tobradex ST a steroid?

"Tobradex ST is a combination of tobramycin, an antibiotic, and dexamethasone, a steroid. It is used to treat bacterial infections of the eyes."

Answered by AI

How long should I use Tobradex eye drops?

"Place one drop in each eye that is affected every 4 to 6 hours while the patient is awake. The dosage may be increased to one drop every two hours during the first 24 to 48 hours. Dosing should not exceed 14 days."

Answered by AI

What is the difference between Tobradex and Tobradex ST?

"While TobraDex ST contains half the amount of dexamethasone as the original TobraDex formulation, it appears to be clinically equivalent to the older formulation."

Answered by AI

What is Tobradex ST used for?

"Dexamethasone belongs to a class of drugs called corticosteroids. It works by decreasing inflammation.

This medication is used to treat or prevent eye infections, containing two drugs. Tobramycin, an aminoglycoside antibiotic, works by stopping the growth of bacteria. Dexamethasone, a corticosteroid, works by decreasing inflammation."

Answered by AI

Clinical Trials for Tobradex St

Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Steroids for Rheumatoid Arthritis

18+

All Sexes

Toronto, Canada

People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Our Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improving symptoms reported by patients? 2. How do the two treatments compare in terms of symptom relief, ability to function, and patient satisfaction? 3. What do patients think and feel about using GCs to treat RA flares? What We Think: We believe that a one-time GC injection is just as good as taking pills for a few weeks when it comes to managing RA flares. In fact, the injection might even be safer and preferred by patients. What We're Doing: We will study 220 adults with RA who are currently having a flare (with at least 3 swollen and tender joints). These patients will be recruited from rheumatology clinics at the University of Toronto and must not have used GCs in the past month. They will be randomly assigned to receive either: A single injection (Methylprednisolone 120 mg), or Oral pills (Prednisone starting at 15 mg daily and tapering down over 3 weeks). The main thing we'll look at is how much better patients feel after 6 weeks, based on a questionnaire designed to measure RA flares. We'll also look at how well they function, how satisfied they are with the treatment, and whether they had any side effects. In addition, 20 patients (10 from each group) will be interviewed to understand their experiences and opinions about flare treatment in more detail. Why This Is Possible: We've already surveyed University of Toronto rheumatologists who support the idea and provided input on study design. We've also partnered with experts in research methods, national arthritis organizations, and patient groups to make sure the study is relevant and meaningful. Ethics approval has been obtained. Why It Matters: RA flares can have a major impact on people's lives. While current treatments help control inflammation, we need to better understand how these treatments affect people from their own perspective. This study will shift the focus to what matters most to patients, helping doctors and patients choose the best treatment based not only on medical results but also on the patient's experience. This could lead to more effective and personalized care for people living with RA.

Phase 4

Waitlist Available

Has No Placebo

Sunnybrook Health Sciences Centre (+4 Sites)

Have you considered Tobradex St clinical trials? We made a collection of clinical trials featuring Tobradex St, we think they might fit your search criteria.

Have you considered Tobradex St clinical trials? We made a collection of clinical trials featuring Tobradex St, we think they might fit your search criteria.