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What is Artane
TrihexyphenidylThe Generic name of this drug
Treatment SummaryTrihexyphenidyl is a medication used to treat Parkinson's disease and other movement disorders caused by certain medications. It was first approved by the FDA in 1949, but it is no longer used as a first-line treatment due to its potential side effects. It has been largely replaced by drugs like Levodopa.
Trihexyphenidyl Hydrochlorideis the brand name
Artane Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trihexyphenidyl Hydrochloride
Trihexyphenidyl
1987
71
Approved as Treatment by the FDA
Trihexyphenidyl, also known as Trihexyphenidyl Hydrochloride, is approved by the FDA for 8 uses which include Parkinson Disease and Extrapyramidal symptoms caused by thioxanthenes .Parkinson Disease
Extrapyramidal symptoms caused by thioxanthenes
Helps manage Extrapyramidal symptoms caused by thioxanthenes
Extrapyramidal symptoms caused by dibenzoxazepines
Helps manage Extrapyramidal symptoms caused by dibenzoxazepines
phenothiazine
Helps manage Extrapyramidal symptoms caused by phenothiazines
Basal Ganglia Diseases
Helps manage Extrapyramidal disorder
Butyrophenones
Helps manage Extrapyramidal symptoms caused by butyrophenones
Parkinsonism post encephalitic
Arteriosclerosis
Effectiveness
How Artane Affects PatientsTrihexyphenidyl is a medicine used to treat Parkinson's disease and other side effects from other drugs. It does not need to be taken every day, and is generally safe to use at high doses. However, people using this drug should have their eyes checked regularly and be warned of the potential risk of lack of sweat and overheating.
How Artane works in the bodyTrihexyphenidyl is a drug that helps treat symptoms of Parkinson’s disease and other movement disorders. It works by blocking a certain type of chemical messenger, called acetylcholine, in the brain and muscles. It is thought to also help increase dopamine levels in the brain, which is beneficial for movement control. The exact way it works is not yet known.
When to interrupt dosage
The suggested measure of Artane is contingent upon the diagnosed state, including phenothiazine, Extrapyramidal reactions caused by dibenzoxazepines and Butyrophenones. The amount of dosage fluctuates, in relation to the administration technique (e.g. Tablet or Tablet - Oral) shown in the following table.Condition
Dosage
Administration
Basal Ganglia Diseases
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Extrapyramidal symptoms caused by dibenzoxazepines
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Extrapyramidal symptoms caused by thioxanthenes
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Arteriosclerosis
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Butyrophenones
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
phenothiazine
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Parkinson Disease
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Parkinsonism post encephalitic
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Warnings
Artane ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Trihexyphenidyl may interact with Pulse Frequency
Common Artane Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Aclidinium.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Trihexyphenidyl is combined with Eluxadoline.
Glycopyrronium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Glycopyrronium.
Ipratropium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Ipratropium.
Artane Toxicity & Overdose RiskOverdosing on trihexyphenidyl can cause dry mouth, no sweating, dilated pupils, nausea, vomiting, rapid heartbeat, high fever, decreased digestion, difficulty urinating, rash, confusion, restlessness, poor coordination, paranoia, psychosis, delirium, and hallucinations. If left untreated, it can lead to respiratory failure, circulatory failure, and death. Treatment includes providing supportive care and airway maintenance, as well as potentially using a drug called physostigmine.
Artane Novel Uses: Which Conditions Have a Clinical Trial Featuring Artane?
Currently, 8 active clinical trials are being conducted to explore the potential of Artane to reduce Extrapyramidal symptoms caused by thioxanthenes, Post-Encephalitic Parkinsonism and Extrapyramidal symptomatology caused by dibenzoxazepines.Condition
Clinical Trials
Trial Phases
Arteriosclerosis
2 Actively Recruiting
Phase 4, Not Applicable
Parkinsonism post encephalitic
0 Actively Recruiting
Extrapyramidal symptoms caused by dibenzoxazepines
0 Actively Recruiting
Butyrophenones
0 Actively Recruiting
Basal Ganglia Diseases
0 Actively Recruiting
Extrapyramidal symptoms caused by thioxanthenes
0 Actively Recruiting
phenothiazine
0 Actively Recruiting
Parkinson Disease
6 Actively Recruiting
Early Phase 1, Phase 2, Not Applicable
Artane Reviews: What are patients saying about Artane?
5Patient Review
6/21/2014 I feel really good when I take this medication. It's a great high and I get really horny, too. The orgasms are also way better.
5Patient Review
10/25/2017 This treatment was good and it helped me.
4.3Patient Review
2/16/2011 I developed tardive dyskenesia from taking abilify, and was prescribed 10mg of Artane. This dosage was far too high for me, and caused extreme short-term memory loss for a few hours after taking it. After several doses, I started to feel nauseous, but drinking orange juice with pulp would help alleviate this. I now only take a quarter of a 5mg pill every now and then, which has kept my symptoms at bay. The Danbury brand is also much better than Qualitest in terms of not upsetting my stomach.
4.3Patient Review
12/21/2013 I have oral mandibular dystonia, which this medication has helped me somewhat with.
4Patient Review
10/25/2014 It increases my appetite and sex drive, as well as making me have to use the restroom more frequently.
3.7Patient Review
9/21/20103.3Patient Review
7/2/20102.3Patient Review
4/24/2022 This medication did its job in that I only had one faint myoclonic jerk while on it. However, I found it to be very cognitively impairing and memory- affecting. All in all, I would not recommend this medication because of these serious side effects.
Patient Q&A Section about artane
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Artane cause anxiety?
"You may experience serious side effects from taking Artane, including fast or irregular heartbeats, anxiety, hallucinations, confusion, agitation, hyperactivity, or loss of consciousness. Seizures and eye pain are also possible. If you experience any of these symptoms, seek medical attention immediately."
Answered by AI
What is the drug Artane used for?
"Artane is an antispasmodic drug that is used to treat symptoms of Parkinson's disease, such as stiffness, tremors, spasms, and poor muscle control. Artane can also be used to prevent these symptoms when they are caused by certain drugs."
Answered by AI
Why is Artane used in schizophrenia?
"Anticholinergic drugs are used in psychiatric practice to counteract the side effect of EPS secondary to antipsychotic drugs. Trihexyphenidyl (Benzhexol), commonly known as 'Artane', is the most widely used anticholinergic drug in Zambia."
Answered by AI
How does Artane make you feel?
"tiredness, lightheadedness, constipation, flushing, nausea, nervousness, blurred vision, or dry mouth may occur. These effects generally improve as your body becomes accustomed to the medication. If any of these effects persist or worsen, contact your doctor or pharmacist."
Answered by AI