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What is Urso Forte
Ursodeoxycholic acidThe Generic name of this drug
Treatment SummaryUrsodeoxycholic acid is a bile acid found in mammals, including bears. It works to change the composition of bile and may dissolve gallstones. This medication is used to increase the flow of bile in the body which can help treat digestive issues.
Actigallis the brand name
Urso Forte Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Actigall
Ursodeoxycholic acid
1987
100
Approved as Treatment by the FDA
Ursodeoxycholic acid, otherwise known as Actigall, is approved by the FDA for 2 uses which include obese experiencing rapid weight loss and Cholelithiasis .obese experiencing rapid weight loss
Cholelithiasis
Effectiveness
How Urso Forte Affects PatientsUrsodiol (also known as ursodeoxycholic acid) is a type of acid that is produced by bacteria in the intestine. It helps to break down dietary fat and helps regulate cholesterol levels by slowing down the rate at which the intestine can absorb it. Ursodeoxycholic acid can also break down micelles containing cholesterol, making it a useful treatment for gallstones that cannot be removed surgically.
How Urso Forte works in the bodyUrsodeoxycholic acid helps reduce high levels of liver enzymes by making it easier for bile to flow through the liver and protecting the liver cells. We don't know all the details of how it works, but it likely involves reducing the amount of cholesterol in bile. This reduces the amount of cholesterol in gallstones, which can eventually dissolve them away.
When to interrupt dosage
The measure of Urso Forte is contingent upon the diagnosed illness, including Primary Biliary Cholangitis, Cholelithiasis and obese individuals going through expeditious weight loss. The measure of dosage can be found in the table below, based on the technique of administration.Condition
Dosage
Administration
obese experiencing rapid weight loss
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental
Cholelithiasis
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental
Liver Cirrhosis, Biliary
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental
Warnings
Urso Forte ContraindicationsCondition
Risk Level
Notes
Cholangitis
Do Not Combine
Pancreatitis
Do Not Combine
biliary gastrointestinal fistula
Do Not Combine
Calcinosis
Do Not Combine
Bile duct structure
Do Not Combine
radiopaque stones
Do Not Combine
radiolucent bile pigment stones
Do Not Combine
Cholecystitis
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ursodeoxycholic Acid may interact with Pulse Frequency
Common Urso Forte Drug Interactions
Drug Name
Risk Level
Description
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Ursodeoxycholic acid.
Rimegepant
Major
The metabolism of Rimegepant can be increased when combined with Ursodeoxycholic acid.
Astemizole
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Astemizole which could result in a higher serum level.
Atazanavir
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Atazanavir which could result in a higher serum level.
Atenolol
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Atenolol which could result in a higher serum level.
Urso Forte Toxicity & Overdose RiskUrsodeoxycholic acid has not been linked to any overdose cases. While doses of 16-20 mg/kg/day have been tolerated for extended periods of time, high doses of 5000 mg/kg for rats or 7500 mg/kg for mice can cause diarrhea. If an overdose occurs, the symptoms should be treated accordingly.
Urso Forte Novel Uses: Which Conditions Have a Clinical Trial Featuring Urso Forte?
Thirteen active studies are currently exploring the potential of Urso Forte to treat Primary Biliary Cholangitis, Cholelithiasis and obese individuals experiencing unexpected weight loss.Condition
Clinical Trials
Trial Phases
Liver Cirrhosis, Biliary
4 Actively Recruiting
Phase 3, Phase 2
Cholelithiasis
0 Actively Recruiting
obese experiencing rapid weight loss
0 Actively Recruiting
Urso Forte Reviews: What are patients saying about Urso Forte?
5Patient Review
11/29/2011 I'm very content with the results this medication has given me. I was worried about the potential side effects, but they haven't been too bad. The only real ones are hair loss, dry mouth and eyes, and nausea if you don't take it with food. Also, it's much cheaper to buy from a Canadian pharmacy when my benefits run out.
5Patient Review
7/27/2010 The only downside I've experienced, after taking this medication for 18 months, is hair loss. My once thick and curly locks are now thinner and straighter. It's not my favorite change, but it's a small price to pay for the positive effects the drug has had on my blood levels.
5Patient Review
8/27/2013 I've been taking this medication for six years now with zero negative side effects. In fact, my liver has actually regenerated since I started taking it!
5Patient Review
8/14/20095Patient Review
10/31/2011 I am very pleased with how well this medication works.
5Patient Review
1/9/2013 I've been taking urso for twelve years and it's worked great until recently. The cost of the medication has gone up, so I switched to ursodil, but it's not working nearly as well. Please help me find a solution.
4.7Patient Review
2/27/2013 I've been prescribed Urso Forte since 2008 and it has taken this long to see a moderating reduction in my liver enzymes, particulary alkaline phosphatase. So it works, but it takes time and this varies greatly among PBC patients.
4.3Patient Review
1/5/2010 I have unfortunately noticed more itching and hair loss since using this treatment. I lose about three times as much hair as normal now.
4.3Patient Review
11/5/2009 My mom takes Urso Forte for her liver and it's really helped. The generic, Urso Diol, is now available but unfortunately she's allergic to it.
4Patient Review
4/9/2010 This treatment is great. It helped me a lot and I'm really thankful for it.
4Patient Review
3/16/2013 I use this and Ursodiol, but I can't tell the difference between the two. They're both working; my last two Meld scores were six.
3.7Patient Review
12/26/2009 I've been taking this medication for seven years now. It's helped my primary biliary cholangitis, but at the cost of a lot of pain in my esophagus, ribs, and back. My brothers have had problems with their intestines and edema. We're all short of breath and tired all the time. Our muscles and joints are always sore.
3.7Patient Review
12/16/2009 My doctor had me on this for my fatty liver (NAFL), and it really helped lower my liver function tests. I'm not sure if this is an off-label use, but it worked well for me.
3.7Patient Review
9/20/2010 I've been using this medication for a long time now, and it's kept my condition stable. I have noticed some hair thinning as a side effect, but that's about it. Recently, I was diagnosed with osteoarthritis and lupus, which have similar symptoms to the side effects of this medication. So now I'm not sure if the Urso is causing those problems or not.
3.3Patient Review
8/3/20093Patient Review
3/16/2010 The price point is a bit high, especially compared to the generic version which has recently come out.
3Patient Review
3/11/2013 I have a lot of trouble with my stomach, so it's sometimes difficult for me to take this medication.
Patient Q&A Section about urso forte
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Urso Forte used for?
"Urso Forte tablets are used to treat primary biliary cirrhosis, an autoimmune disorder that causes progressive destruction of the bile ducts in your liver. Urso Forte may also be used to treat other conditions not listed in this medication guide."
Answered by AI
What are the side effects of Urso?
"You may have an upset stomach, nausea, vomiting, diarrhea, or constipation. You may also have a cough, sore throat, or painful urination. You may even experience hair loss or back pain."
Answered by AI
What does Urso do for the liver?
"Ursodiol is a medication that helps dissolve gallstones and prevents them from forming. It does this by reducing the production of cholesterol and dissolving the cholesterol in bile. It also lowers the levels of harmful bile acids that can build up in people with primary biliary cirrhosis."
Answered by AI
Who makes Urso Forte?
"Copyright © 2020 Allergan. All rights reserved.
The Allergan drugs URSO 250® and URSO Forte® can interact with other drugs. Copyright © 2020 Allergan. All rights reserved."
Answered by AI