← Back to Search

MIND Diet for Cognitive Decline

N/A

Recruiting

Led By Christy Tangney, PhD

Research Sponsored by Rush University Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adequate visual and auditory acuity to undergo neuropsychological testing

Acute stroke as defined by an acute focal neurological deficit in combination with acute ischemic infarct (stroke) as documented by either a DWI positive lesion on MR imaging or a new lesion on a delayed CT scan

Must not have

Patients presenting one of the following diseases: cerebral venous thrombosis, traumatic cerebral hemorrhage, intracerebral hemorrhage because of a known or image-guided assumed vascular malformation, pure meningeal or intraventricular hemorrhage

Unstable or recent onset of cardiovascular disease, such as myocardial infarction within six months or presence of congestive heart failure (Stages II-IV)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3-years

Summary

This trial will test the effects of the MIND diet on cognitive decline, dementia, and brain biomarkers of Alzheimer's Disease and vascular disease in 500 patients who have had a stroke.

Who is the study for?

This trial is for stroke patients aged 55 or older, who are going home after hospitalization and can give consent. They must be able to see and hear well enough for tests, have had an acute ischemic stroke confirmed by MRI or CT scan, but not have dementia or cognitive impairment before the stroke.

What is being tested?

The study compares the MIND diet—a specific dietary plan designed to reduce neurodegenerative decline—with usual care diets in post-stroke patients. It aims to observe effects on cognitive decline and brain markers related to Alzheimer's Disease over a period of 2-3 years.

What are the potential side effects?

Since this trial involves dietary interventions rather than medications, side effects may include changes in digestion or food sensitivities due to new eating habits. However, no significant medical side effects like those seen with drugs are expected.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I can see and hear well enough to take psychological tests.

Select...

I recently had a stroke confirmed by an MRI or a CT scan.

Select...

I can see and hear well enough to take psychological tests.

Select...

I am 55 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have a brain-related blood clot or bleeding due to a vascular issue.

Select...

I have not had a heart attack in the last 6 months or severe heart failure.

Select...

I was diagnosed with dementia or mild cognitive impairment before being hospitalized.

Select...

I am taking medication for Alzheimer's or Parkinson's disease.

Select...

I have a history of liver disease, HIV, or Hepatitis C.

Select...

My doctor expects I have less than 3 years to live due to my cancer.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3-years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3-years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3-years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in global cognitive score

Secondary study objectives

Change in 5 individual cognitive domains

Change in brain MRI derived markers of macro and micro structural integrity (cubic Centimeters), total brain volume, hippocampal volume and white matter hyperintensity volume ( cubic centimeters)