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What is Wellbutrin
BupropionThe Generic name of this drug
Treatment SummaryBupropion (also known as Wellbutrin®) is a medication used to treat Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and to help people quit smoking. It works by blocking certain enzymes that cause the brain to absorb certain neurotransmitters, such as norepinephrine and dopamine, for a longer period of time. Unlike other antidepressants, Bupropion does not affect serotonin levels and is less likely to cause sexual side effects, sedation, or weight gain. Bupropion can also be used as an add-on medication when the first-line treatments of depression
Wellbutrinis the brand name
Wellbutrin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Wellbutrin
Bupropion
1986
741
Approved as Treatment by the FDA
Bupropion, also known as Wellbutrin, is approved by the FDA for 3 uses which include Depression and Smoke .Depression
Smoke
Smoking Cessation
Effectiveness
How Wellbutrin Affects PatientsBupropion is a type of drug used to treat depression that is not related to other antidepressant medications. It helps balance the levels of dopamine and norepinephrine in the brain, but does not affect serotonin. Bupropion can cause stimulant effects in some people, making it potentially addictive. It can also lower the seizure threshold, making it dangerous for people with pre-existing seizure conditions. Finally, it can raise blood pressure, so it is not advised for those with high blood pressure or cardiovascular disease.
How Wellbutrin works in the bodyBupropion is a drug that works on two of our brain's neurotransmitters: norepinephrine and dopamine. It stops them from leaving the brain quickly, so that their effects can be felt for longer. This makes it useful for treating depression and helping with smoking cessation. When combined with naltrexone in the drug Contrave, bupropion is thought to work on the brain's appetite regulation pathways, reducing food intake and increasing energy expenditure.
When to interrupt dosage
The suggested measure of Wellbutrin is contingent upon the determined condition, for example, Depressive Bipolar Disorder, Depression and Disease. The amount as well changes according to the technique of delivery (e.g. Tablet, extended release or Tablet, film coated, extended release) presented in the table below.Condition
Dosage
Administration
Reducing diet
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Obesity
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Seasonal Affective Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Mood Disorders
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoking Cessation
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Attention Deficit Hyperactivity Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoke
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Depression
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Warnings
Wellbutrin ContraindicationsCondition
Risk Level
Notes
Bulimia Nervosa
Do Not Combine
ethanol
Do Not Combine
Hypertensive disease
Do Not Combine
Anorexia Nervosa
Do Not Combine
abrupt cessation of barbiturates
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Epilepsy
Do Not Combine
abrupt cessation of antiepileptic drugs
Do Not Combine
Benzodiazepines
Do Not Combine
Pulse Frequency
Do Not Combine
Anorexia Nervosa
Do Not Combine
Anorexia Nervosa
Do Not Combine
Common Wellbutrin Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Bupropion.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Bupropion.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Bupropion.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Bupropion.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Bupropion.
Wellbutrin Toxicity & Overdose RiskSymptoms of an overdose on this drug may include seizures, seeing and hearing things that are not real, passing out, rapid heartbeat, and heart failure.
Wellbutrin Novel Uses: Which Conditions Have a Clinical Trial Featuring Wellbutrin?
Currently, there are 490 active trials examining the effectiveness of Wellbutrin in treating Attention Deficit Hyperactivity Disorder, Depression and aiding Smoking Cessation.Condition
Clinical Trials
Trial Phases
Smoking Cessation
101 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3
Obesity
49 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Attention Deficit Hyperactivity Disorder
68 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1, Early Phase 1
Depression
190 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Mood Disorders
21 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 1
Seasonal Affective Disorder
0 Actively Recruiting
Smoke
0 Actively Recruiting
Reducing diet
0 Actively Recruiting
Patient Q&A Section about wellbutrin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the mental side effects of Wellbutrin?
"Bupropion may cause people to feel agitated, irritable, or display other abnormal behaviors. It may also cause people to have suicidal thoughts or tendencies, or to become more depressed."
Answered by AI
What does Wellbutrin do to you?
"Bupropion is used to treat depression by restoring the balance of certain natural chemicals in your brain."
Answered by AI
What does Wellbutrin treat best?
"Bupropion is a medication used to treat depression. It is available under the brand names Aplenzin, Wellbutrin, Wellbutrin SR, and Wellbutrin XL."
Answered by AI
What does Wellbutrin do for you?
"Loss of interest or pleasure in activities.
Bupropion is an antidepressant medication that affects the brain. It is approved to treat major depressive disorder, seasonal affective disorder, and to help people quit smoking. Symptoms of depression include feeling sad, empty, or tearful, and loss of interest or pleasure in activities."
Answered by AI
What is the downside of Wellbutrin?
"Side effects that are commonly experienced by people who take WELLBUTRIN include feeling agitated, having a dry mouth, trouble sleeping, headaches/migraines, nausea/vomiting, constipation, trembling, feeling dizzy, sweating a lot, blurry vision, having a fast heart rate, feeling confused, being hostile, and having problems with hearing."
Answered by AI