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What is Zylet
TobramycinThe Generic name of this drug
Treatment SummaryAminoglycosides, many of which are derived directly from _Streptomyces_ spp., are concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative organisms.[A232294] Inhaled tobramycin is notable for its use in treating chronic _Pseudomonas aeruginosa_ infections in cystic fibrosis patients, as _P. aeruginosa_ is notoriously inherently resistant to many antibiotics.[A232294, A232299, L32739] However, tobramycin can also be administered intravenously and topically to treat a variety of infections caused by susceptible bacteria.[L32744, L32749] Its use is limited in some cases by characteristic toxicities such as nephrotoxicity and ototoxicity, yet it remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins.[A232294, A232349, L32739, L32749]
Tobramycin was approved by the FDA in 1975 and is currently available in a variety of forms for administration by inhalation, injection, and external application to the eye (ophthalmic).[L32739, L32744, L32749]
Tobrexis the brand name
Zylet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tobrex
Tobramycin
1981
166
When to interrupt dosage
The recommended measure of Zylet is contingent upon the diagnosed issue, for instance Ocular Inflammation, Conjunctivitis infective and Herpes Zoster Keratitis. Dosage additionally relies upon the strategy of administration (e.g. Gel - Ophthalmic or Suspension / drops) as detailed in the table beneath.Condition
Dosage
Administration
Bacteria
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Cystic Fibrosis
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
ocular bacterial infections
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Eye Infections, Bacterial
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Bone Infection
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Intraabdominal Infections
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Burkholderia Cepacia Infection
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
concomitant use of NSAID
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Inflammation
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Eye Infections
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
External auditory canal structure
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Urinary tract infection
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Bacterial Peritonitis
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
FEV1 <25% predicted
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Septicemia
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Bacterial Infections
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Conjunctivitis
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Cystic Fibrosis
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Meningitis, Bacterial
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Adrenal Cortex Hormones
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Solution - Oral, Solution, Solution / drops, Solution / drops - Ophthalmic, Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Suspension, Suspension - Ophthalmic, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Respiratory (inhalation), Solution - Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Liquid, Liquid - Ophthalmic, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Inhalant, Inhalant - Respiratory (inhalation), Solution - Oral; Respiratory (inhalation)
Warnings
Zylet has eight contraindications, and thus should not be ingested when dealing with any of the conditions identified in the following table.Zylet ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Zylet Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Tobramycin is combined with Neomycin.
Tenofovir
Major
Tobramycin may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Tobramycin may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Tobramycin may increase the nephrotoxic activities of Tenofovir disoproxil.
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Tobramycin.
Zylet Novel Uses: Which Conditions Have a Clinical Trial Featuring Zylet?
Currently, 198 active trials are investigating the potential of Zylet to alleviate Seasonal Allergic Conjunctivitis, Iritis and Ocular Inflammation.Condition
Clinical Trials
Trial Phases
Bacterial Infections
0 Actively Recruiting
Meningitis, Bacterial
0 Actively Recruiting
Bacteria
0 Actively Recruiting
Inflammation
0 Actively Recruiting
Eye Infections
0 Actively Recruiting
concomitant use of NSAID
0 Actively Recruiting
Cystic Fibrosis
0 Actively Recruiting
Bone Infection
1 Actively Recruiting
Phase 2
Burkholderia Cepacia Infection
0 Actively Recruiting
Adrenal Cortex Hormones
0 Actively Recruiting
Bacterial Peritonitis
0 Actively Recruiting
FEV1 <25% predicted
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting
Eye Infections, Bacterial
1 Actively Recruiting
Phase 4
ocular bacterial infections
0 Actively Recruiting
Cystic Fibrosis
0 Actively Recruiting
Intraabdominal Infections
1 Actively Recruiting
Not Applicable
Septicemia
0 Actively Recruiting
External auditory canal structure
0 Actively Recruiting
Otitis
0 Actively Recruiting
Zylet Reviews: What are patients saying about Zylet?
5Patient Review
5/3/2016 I had no idea there were different types of pink eye, but I'm glad I found this medication. After just one dosage, the puffiness and redness around my eyes went away.
5Patient Review
12/13/2010 I started seeing results after the first day of use. By the third day, my eyes were noticeably improved. This medication is working well for me and I am much better off because of it.
5Patient Review
7/8/2014 Zylet was extremely effective in treating my infection and reducing the pain. I followed the instructions to a tee and saw results very quickly.
5Patient Review
10/12/2011 Zylet is extremely effective for me. Within minutes of using it, my eyes stopped itching and the redness disappeared. My allergies have improved a lot since I started using this product.
4.3Patient Review
6/3/2011 I started using this for allergic scleritis after lotemax failed to produce results. I noticed an immediate improvement upon use. I have had some excessive tearing, but as I already have dry-eye syndrome, it's not a huge deal to me.
3Patient Review
9/29/2010 This treatment was effective for a time, but eventually the problem came back.
2Patient Review
12/23/2013 I've been using the drops for five days now and, unfortunately, have only experienced more severe itching in my upper eyelid and face. I took Benedryl but it didn't help at all. I'm going to be contacting my doctor today.
2Patient Review
2/28/2012 These drops were very expensive and unfortunately, they actually increased the pain I was experiencing. I had to discontinue use after only a day because the pain was unbearable. If you have dry eye, I would recommend avoiding this medication as it will likely make your symptoms worse.
2Patient Review
6/22/2010 I used this drug for 2/1/2 months without seeing any improvement.
1.7Patient Review
7/27/2010 My 87 year old mother took this medication and had a really adverse reaction. Her face got red, swollen, and developed sores. She only used the medication for a day or two before discontinuing use, but even still 3 days later she's experiencing these side effects.
1Patient Review
12/19/2010 After using this medication for my elderly mother (as directed, one drop in each eye twice daily), she has been complaining of pain almost constantly. I notified the prescribing doctor and was told to use a different product alongside it; however, this has not alleviated the issue at all and may even be making it worse. I cannot continue putting her through this much discomfort and will stop the medication tomorrow morning.
1Patient Review
11/3/2011 After applying the drops to my eye, I experienced horrible pain and stinging. This made my condition worse instead of better. Save yourself the money and get a sample from your doctor before buying this non-generic medication.
1Patient Review
5/30/2015 After just three weeks of using this medication as prescribed, I developed vertigo and double vision. This led to a hospital stay for testing, which showed no cause for my symptoms. However, I'm confident that the Zylet is to blame. It's been seven months since I stopped taking it, and though the vertigo has subsided somewhat, the double vision persists and prevents me from driving.
Patient Q&A Section about zylet
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Zylet a steroid?
"Zylet is a brand medication that is a combination of a steroid and antibiotic. It is effective in treating eye inflammation and bacterial eye infections. However, it can cause high eye pressure and eye injury if used for a long period of time."
Answered by AI
What is Zylet used to treat?
"This medication is used to treat conditions involving swelling (inflammation) of the eyes and to treat or prevent bacterial eye infections. This product contains tobramycin, an antibiotic. Tobramycin works by stopping the growth of bacteria."
Answered by AI
How long does it take for Zylet to work?
"You may be at an increased risk of developing an eye infection or its severity may worsen if you take corticosteroids. If you don't see an improvement in your symptoms after two days of using ZYLET®, you should consult your doctor."
Answered by AI
What are the side effects of Zylet eye drops?
"Some common side effects of taking Zylet include a burning or stinging feeling in the eyes, itchiness, redness, or discomfort. Other potential side effects include headaches, light sensitivity, and blurred vision."
Answered by AI