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Children's Hospital of Orange County
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Orange, California 92868
Global Leader in Cancer
Global Leader in Solid Tumors
Conducts research for Brain Tumor
Conducts research for Acute Lymphoblastic Leukemia
Conducts research for Leukemia
527 reported clinical trials
22 medical researchers
Summary
Children's Hospital of Orange County is a medical facility located in Orange, California. This center is recognized for care of Cancer, Solid Tumors, Brain Tumor, Acute Lymphoblastic Leukemia, Leukemia and other specialties. Children's Hospital of Orange County is involved with conducting 527 clinical trials across 816 conditions. There are 22 research doctors associated with this hospital, such as Elyssa M. Rubin, Mariko Sato, Josephine H. Haduong, and Raymond Wang, MD.
Area of expertise
Cancer
Children's Hospital of Orange County has run 75 trials for Cancer. Some of their research focus areas include:
Solid Tumors
Children's Hospital of Orange County has run 72 trials for Solid Tumors. Some of their research focus areas include:
Top PIs
Elyssa M. Rubin
Children's Hospital of Orange County
8 years of reported clinical research
Mariko Sato
University of Iowa/Holden Comprehensive Cancer Center
8 years of reported clinical research
Josephine H. Haduong
Children's Hospital of Orange County
10 years of reported clinical research
Raymond Wang, MD
Children's Hospital of Orange County (CHOC)
2 years of reported clinical research
Clinical Trials running at Children's Hospital of Orange County
Cancer
Brain Tumor
Leukemia
Testicular cancer
Solid Tumors
Brain Cancer
Wilms Tumor
Neuroblastoma
Burkitt Lymphoma
Ovarian Cancer
Chemotherapy
for Cancer
This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The trial studies whether carboplatin or cisplatin is the preferred chemotherapy to use in treating metastatic standard risk germ cell tumors.
Recruiting
2 awards
Phase 3
26 criteria
Triptorelin
for Cancer
This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agents. Alkylating agents are part of standard chemotherapy, but may cause damage to the ovaries. If the ovaries are not working well or completely shut down, then it will be difficult or impossible to get pregnant in the future. Triptorelin works by blocking certain hormones and causing the ovaries to slow down or pause normal activity. The triptorelin used in this study stays active in the body for 24 weeks or about 6 months after a dose is given. After triptorelin is cleared from the body, the ovaries resume normal activities. Adding triptorelin before the start of chemotherapy treatment may reduce the chances of damage to the ovaries.
Recruiting
2 awards
Phase 3
4 criteria
Tagraxofusp
for Blood Cancers
Tagraxofusp is a protein-drug conjugate consisting of a diphtheria toxin redirected to target CD123 has been approved for treatment in pediatric and adult patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). This trial aims to examine the safety of this novel agent in pediatric patients with relapsed/refractory hematologic malignancies. The mechanism by which tagraxofusp kills cells is distinct from that of conventional chemotherapy. Tagraxofusp directly targets CD123 that is present on tumor cells, but is expressed at lower or levels or absent on normal hematopoietic stem cells. Tagraxofusp also utilizes a payload that is not cell cycle dependent, making it effective against both highly proliferative tumor cells and also quiescent tumor cells. The rationale for clinical development of tagraxofusp for pediatric patients with hematologic malignancies is based on the ubiquitous and high expression of CD123 on many of these diseases, as well as the highly potent preclinical activity and robust clinical responsiveness in adults observed to date. This trial includes two parts: a monotherapy phase and a combination chemotherapy phase. This design will provide further monotherapy safety data and confirm the FDA approved pediatric dose, as well as provide safety data when combined with chemotherapy. The goal of this study is to improve survival rates in children and young adults with relapsed hematological malignancies, determine the recommended phase 2 dose (RP2D) of tagraxofusp given alone and in combination with chemotherapy, as well as to describe the toxicities, pharmacokinetics, and pharmacodynamic properties of tagraxofusp in pediatric patients. About 54 children and young adults will participate in this study. Patients with Down syndrome will be included in part 1 of the study.
Recruiting
1 award
Phase 1
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Frequently asked questions
What kind of research happens at Children's Hospital of Orange County?
Children's Hospital of Orange County is a medical facility located in Orange, California. This center is recognized for care of Cancer, Solid Tumors, Brain Tumor, Acute Lymphoblastic Leukemia, Leukemia and other specialties. Children's Hospital of Orange County is involved with conducting 527 clinical trials across 816 conditions. There are 22 research doctors associated with this hospital, such as Elyssa M. Rubin, Mariko Sato, Josephine H. Haduong, and Raymond Wang, MD.
Where is Children's Hospital of Orange County located?
**Children's Hospital of Orange County (CHOC)** Location: 1201 W. La Veta Ave., Orange, CA For check-in, proceed to the Bill Holmes Tower entrance located on Pepper Street and follow the signs to the front entrance.
Who should I call to ask about financial aid or insurance network?
For assistance with questions on billing, our contact process involves the following steps: 1. For billing questions, contact the **Contact Process**: - **Phone Call**: Our **Contact Process** involves the following steps: - For billing questions, contact the **Contact Process**: - **Phone Call**: Our **Phone Call** involves the process of contacting us via phone. - **Phone Call**: Our **Phone Call** involves the process of contacting us via phone. 2. **Phone Call**: Our **Phone Call** involves the process of contacting us via phone. 3. **Phone Call**: Our **Phone Call** involves the process of contacting us via phone.
What insurance does Children's Hospital of Orange County accept?
The Children's Hospital of Orange County (CHOC) accepts a wide range of insurance plans, including most major PPO, HMO, and Medicare plans. They are contracted with various managed care organizations, including Aetna, Blue Cross of California, Blue Shield of California, Cigna Healthcare, HealthNet, and United HealthCare. For specific information about coverage or inquiries regarding specialist charges, it is recommended to contact your insurance carrier or the physician directly.
What awards or recognition has Children's Hospital of Orange County received?
Children's Hospital of Orange County (CHOC) in Orange, California, is a Level I pediatric trauma center, accredited by the American College of Surgeons (ACS) and Orange County Emergency Services. It has been designated as a Rare Disease Center of Excellence, focusing on novel cures for rare disorders. Additionally, CHOC has earned Magnet recognition for nursing excellence from the American Nurses Credentialing Center for the fourth time.
Unbiased Results
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Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.