NMDA Receptor Antagonist
Ketamine for Obsessive-Compulsive Disorder
Recruiting1 awardPhase 2
Stanford, California
This trial aims to understand how ketamine quickly improves symptoms in people with Obsessive-Compulsive Disorder (OCD). Ketamine works by blocking a specific brain receptor, which helps reduce repetitive thoughts and behaviors. Recent research demonstrated that ketamine rapidly reduces OCD symptoms. The study focuses on how this process happens at different levels in the brain.
Cannabinoid
Cannabidiol for Obsessive-Compulsive Disorder
Recruiting1 awardPhase 2
Chicago, Illinois
This trial aims to test if Epidiolex can safely and effectively reduce symptoms in adults with obsessive-compulsive and related disorders by calming the brain and reducing anxiety. Epidiolex is a plant-derived pharmaceutical formulation of highly purified cannabidiol (CBD) that has been previously studied for its potential to be misused.
Behavioural Intervention
Brain Stimulation for Obsessive-Compulsive Disorder
Recruiting1 award
San Francisco, California
This trial is looking for better ways to treat OCD by identifying abnormal brain signals associated with the disorder and psychiatric symptoms, and investigating whether novel therapeutic stimulation sites can help improve OCD symptoms.
Behavioural Intervention
Mindfulness-Based Interventions for Obsessive-Compulsive Disorder
Recruiting1 award
Hamilton, Ontario
This trial is testing a new treatment called Mindfulness-Based Cognitive Therapy (MBCT) for people with Obsessive-Compulsive Disorder (OCD) who haven't fully benefited from standard treatments. MBCT helps patients become more aware of their thoughts and feelings without reacting to them, which can reduce OCD symptoms. If successful, this approach could be used widely in clinical settings to help more people with OCD. Mindfulness-Based Cognitive Therapy (MBCT) has been shown to be effective in various mental disorders and is now being explored as a complementary treatment for OCD, particularly for those who do not fully benefit from standard treatments.
Behavioural Intervention
Dextromethorphan + Fluoxetine for Obsessive-Compulsive Disorder
Recruiting1 awardPhase 2
Stanford, California
This trial is testing if a common cough medicine can help when taken with a low dose of a usual obsessive-compulsive disorder (OCD) medication. It targets patients with OCD and related disorders who often do not get enough help from current treatments. The cough medicine might work with the usual drug to better control troubling thoughts and actions. The usual medication is a well-established treatment for obsessive-compulsive disorder and has been shown to be effective in multiple studies.
Popular Filters
Trials for Obsessive-Compulsive Disorder Patients
Behavioral Intervention
Transcranial Magnetic Stimulation + Habit Training for Compulsive Behavior
Recruiting0 awards4 criteria
Pittsburgh, Pennsylvania
This trial uses a device that sends mild electrical signals to the brain and combines it with computer exercises. It aims to help people who have trouble controlling repetitive behaviors. The goal is to change brain activity and improve control over these behaviors.
Transcranial Magnetic Stimulation
Accelerated Theta-Burst Stimulation for Obsessive-Compulsive Disorder
Recruiting1 award6 criteria
Stanford, California
This trial will test if an accelerated schedule of theta-burst stimulation using a TMS device can help people with OCD who haven't responded to other treatments.
Deep Brain Stimulation
Deep Brain Stimulation for Obsessive-Compulsive Disorder
Recruiting1 award16 criteria
Pittsburgh, Pennsylvania
This trial is for people with a hard-to-control form of OCD. The goal is to find a more reliable system for treating OCD by studying how to best place electrodes in the brain to deliver electrical stimulation.
Selective Serotonin Reuptake Inhibitor
Fluoxetine for Obsessive-Compulsive Disorder
Recruiting1 awardPhase 1 & 2
New Haven, Connecticut
This trial uses brain scans and fluoxetine to treat unmedicated OCD patients. It aims to see how the brain changes with treatment and identify markers that predict treatment success. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), has been used for many years to treat obsessive-compulsive disorder (OCD) and is recognized for its efficacy in reducing both obsessions and compulsions.
Inhaled Anesthetic
Nitrous Oxide for Obsessive-Compulsive Disorder
Recruiting0 awardsPhase 2
Stanford, California
This trial uses nitrous oxide gas, commonly known as laughing gas, to see if it can quickly help people with OCD. It targets individuals with OCD because they often struggle with persistent and distressing thoughts and behaviors. The gas might work by altering brain chemicals to improve mood and reduce symptoms.
Trials for Hoarding Disorder Patients
Behavioral Intervention
Transcranial Magnetic Stimulation + Habit Training for Compulsive Behavior
Recruiting0 awards4 criteria
Pittsburgh, Pennsylvania
This trial uses a device that sends mild electrical signals to the brain and combines it with computer exercises. It aims to help people who have trouble controlling repetitive behaviors. The goal is to change brain activity and improve control over these behaviors.
Transcranial Magnetic Stimulation
Accelerated Theta-Burst Stimulation for Obsessive-Compulsive Disorder
Recruiting1 award6 criteria
Stanford, California
This trial will test if an accelerated schedule of theta-burst stimulation using a TMS device can help people with OCD who haven't responded to other treatments.
Deep Brain Stimulation
Deep Brain Stimulation for Obsessive-Compulsive Disorder
Recruiting1 award16 criteria
Pittsburgh, Pennsylvania
This trial is for people with a hard-to-control form of OCD. The goal is to find a more reliable system for treating OCD by studying how to best place electrodes in the brain to deliver electrical stimulation.
Selective Serotonin Reuptake Inhibitor
Fluoxetine for Obsessive-Compulsive Disorder
Recruiting1 awardPhase 1 & 2
New Haven, Connecticut
This trial uses brain scans and fluoxetine to treat unmedicated OCD patients. It aims to see how the brain changes with treatment and identify markers that predict treatment success. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), has been used for many years to treat obsessive-compulsive disorder (OCD) and is recognized for its efficacy in reducing both obsessions and compulsions.
Inhaled Anesthetic
Nitrous Oxide for Obsessive-Compulsive Disorder
Recruiting0 awardsPhase 2
Stanford, California
This trial uses nitrous oxide gas, commonly known as laughing gas, to see if it can quickly help people with OCD. It targets individuals with OCD because they often struggle with persistent and distressing thoughts and behaviors. The gas might work by altering brain chemicals to improve mood and reduce symptoms.
Phase 3 Trials
Behavioural Intervention
Troriluzole for Obsessive-Compulsive Disorder
Recruiting0 awardsPhase 2 & 3
Chandler, Arizona
This trial is testing troriluzole to see if it can help people with OCD who haven't improved with common medications. Troriluzole works by balancing brain chemicals that may be causing OCD symptoms. The goal is to find a more effective treatment for those who need additional help.
Adjunctive Troriluzole for OCD
Recruiting1 awardPhase 3
Phoenix, Arizona
This trial is testing a new medication called troriluzole to see if it helps people with OCD who aren't getting enough relief from their current treatments. Troriluzole is added to their existing medications and works by changing brain chemicals to reduce OCD symptoms. Troriluzole is related to riluzole, which has shown benefits in treating OCD when used alongside existing treatments.
Procedure
Ventral Capsulotomy for Obsessive-Compulsive Disorder
Recruiting2 awardsPhase 3
Providence, Rhode Island
This trial will study a neurosurgery procedure to treat OCD patients who have not improved with conventional therapies. It will examine effects on brain pathways and cognitive tasks to assess its efficacy.
Long-Term Safety of Troriluzole for OCD
Recruiting2 awardsPhase 3
Chandler, Arizona
This trial is testing the safety and tolerability of troriluzole as an additional treatment for people with OCD. Troriluzole may help balance brain chemicals to reduce OCD symptoms. Troriluzole is related to riluzole, which has been studied for its potential benefits in treating anxiety disorders and OCD.
Trials With No Placebo
Transcranial Magnetic Stimulation
Accelerated Theta-Burst Stimulation for Obsessive-Compulsive Disorder
Recruiting1 award6 criteria
Stanford, California
This trial will test if an accelerated schedule of theta-burst stimulation using a TMS device can help people with OCD who haven't responded to other treatments.
Deep Brain Stimulation
Deep Brain Stimulation for Obsessive-Compulsive Disorder
Recruiting1 award16 criteria
Pittsburgh, Pennsylvania
This trial is for people with a hard-to-control form of OCD. The goal is to find a more reliable system for treating OCD by studying how to best place electrodes in the brain to deliver electrical stimulation.
Selective Serotonin Reuptake Inhibitor
Fluoxetine for Obsessive-Compulsive Disorder
Recruiting1 awardPhase 1 & 2
New Haven, Connecticut
This trial uses brain scans and fluoxetine to treat unmedicated OCD patients. It aims to see how the brain changes with treatment and identify markers that predict treatment success. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), has been used for many years to treat obsessive-compulsive disorder (OCD) and is recognized for its efficacy in reducing both obsessions and compulsions.
Device
Adaptive DBS for Obsessive-Compulsive Disorder
Recruiting1 award
Pittsburgh, Pennsylvania
This trial is for people with OCD who have not responded to other treatments. The goal is to use signals from the brain to automatically adjust the Deep Brain Stimulation (DBS) stimulation factors to improve symptom management and reduce stimulation-induced behavioral side effects.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.