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Dayton Children's Hospital
Claim this profileDayton, Ohio 45404
Global Leader in Leukemia
Global Leader in Tumors
Conducts research for Brain Tumor
Conducts research for Lymphoma
Conducts research for Lymphoblastic Leukemia-Lymphoma
257 reported clinical trials
5 medical researchers
Summary
Dayton Children's Hospital is a medical facility located in Dayton, Ohio. This center is recognized for care of Leukemia, Tumors, Brain Tumor, Lymphoma, Lymphoblastic Leukemia-Lymphoma and other specialties. Dayton Children's Hospital is involved with conducting 257 clinical trials across 417 conditions. There are 5 research doctors associated with this hospital, such as Mukund G. Dole, Alvin C Jones, MD, Shobhan Vachhrajani, MD, PhD, and Jeffrey Pence, MD.Area of expertise
1Leukemia
Global LeaderNTRK1 positive
NTRK positive
Stage II
2Tumors
Global LeaderStage IV
Stage I
Stage II
Top PIs
Mukund G. DoleDayton Children's Hospital7 years of reported clinical research
Expert in Tumors
Expert in Brain Tumor
53 reported clinical trials
105 drugs studied
Alvin C Jones, MDDayton Children's Hospital4 years of reported clinical research
Studies Scoliosis
Studies Adolescent Idiopathic Scoliosis
1 reported clinical trial
1 drug studied
Shobhan Vachhrajani, MD, PhDDayton Children's Hospital5 years of reported clinical research
Studies Traumatic Brain Injury
Studies Intracranial Hemorrhage
1 reported clinical trial
1 drug studied
Jeffrey Pence, MDDayton Children's Hospital5 years of reported clinical research
Studies Traumatic Brain Injury
Studies Intracranial Hemorrhage
1 reported clinical trial
1 drug studied
Clinical Trials running at Dayton Children's Hospital
Brain Tumor
Osteosarcoma
Germ Cell Tumors
Langerhans Cell Histiocytosis
Rhabdomyosarcoma
Non-Hodgkin's Lymphoma
Acute Lymphoblastic Leukemia
Astrocytoma
Acute Myeloid Leukemia
Neuroblastoma
Selumetinib vs Carboplatin/Vincristine
for Brain Cancer
This phase III trial studies if selumetinib works just as well as the standard treatment with carboplatin/vincristine (CV) for subjects with NF1-associated low grade glioma (LGG), and to see if selumetinib is better than CV in improving vision in subjects with LGG of the optic pathway (vision nerves). Selumetinib is a drug that works by blocking some enzymes that low-grade glioma tumor cells need for their growth. This results in killing tumor cells. Drugs used as chemotherapy, such as carboplatin and vincristine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether selumetinib works better in treating patients with NF1-associated low-grade glioma compared to standard therapy with carboplatin and vincristine.
Recruiting2 awards Phase 328 criteria
Selumetinib vs. Chemotherapy
for Brain Cancer
This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.
Recruiting2 awards Phase 3
Selumetinib + Vinblastine
for Low-Grade Glioma
This phase III trial investigates the best dose of vinblastine in combination with selumetinib and the benefit of adding vinblastine to selumetinib compared to selumetinib alone in treating children and young adults with low-grade glioma (a common type of brain cancer) that has come back after prior treatment (recurrent) or does not respond to therapy (progressive). Selumetinib is a drug that works by blocking a protein that lets tumor cells grow without stopping. Vinblastine blocks cell growth by stopping cell division and may kill cancer cells. Giving selumetinib in combination with vinblastine may work better than selumetinib alone in treating recurrent or progressive low-grade glioma.
Recruiting2 awards Phase 339 criteria
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Frequently asked questions
What kind of research happens at Dayton Children's Hospital?
Dayton Children's Hospital is a medical facility located in Dayton, Ohio. This center is recognized for care of Leukemia, Tumors, Brain Tumor, Lymphoma, Lymphoblastic Leukemia-Lymphoma and other specialties. Dayton Children's Hospital is involved with conducting 257 clinical trials across 417 conditions. There are 5 research doctors associated with this hospital, such as Mukund G. Dole, Alvin C Jones, MD, Shobhan Vachhrajani, MD, PhD, and Jeffrey Pence, MD.