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East Tennessee Childrens Hospital
Claim this profileKnoxville, Tennessee 37916
Global Leader in Leukemia
Global Leader in Tumors
Conducts research for Sarcoma
Conducts research for Brain Tumor
Conducts research for Lymphoma
211 reported clinical trials
2 medical researchers
Summary
East Tennessee Childrens Hospital is a medical facility located in Knoxville, Tennessee. This center is recognized for care of Leukemia, Tumors, Sarcoma, Brain Tumor, Lymphoma and other specialties. East Tennessee Childrens Hospital is involved with conducting 211 clinical trials across 346 conditions. There are 2 research doctors associated with this hospital, such as Susan E. Spiller and Ray C. Pais.Area of expertise
1Leukemia
Global LeaderStage II
Philadelphia chromosome positive
BCR-ABL1 fusion positive
2Tumors
Global LeaderStage IV
Stage I
Stage II
Top PIs
Susan E. SpillerEast Tennessee Childrens Hospital7 years of reported clinical research
Expert in Tumors
Expert in Brain Tumor
46 reported clinical trials
99 drugs studied
Ray C. PaisEast Tennessee Childrens Hospital18 years of reported clinical research
Studies Leukemia
Studies Lymphoblastic Leukemia-Lymphoma
8 reported clinical trials
30 drugs studied
Clinical Trials running at East Tennessee Childrens Hospital
Brain Tumor
Osteosarcoma
Germ Cell Tumors
Rhabdomyosarcoma
Non-Hodgkin's Lymphoma
Astrocytoma
Langerhans Cell Histiocytosis
Acute Lymphoblastic Leukemia
Neuroectodermal Tumors
Rhabdoid Tumor
Selumetinib vs. Chemotherapy
for Brain Cancer
This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.
Recruiting2 awards Phase 3
Selumetinib vs Carboplatin/Vincristine
for Brain Cancer
This phase III trial studies if selumetinib works just as well as the standard treatment with carboplatin/vincristine (CV) for subjects with NF1-associated low grade glioma (LGG), and to see if selumetinib is better than CV in improving vision in subjects with LGG of the optic pathway (vision nerves). Selumetinib is a drug that works by blocking some enzymes that low-grade glioma tumor cells need for their growth. This results in killing tumor cells. Drugs used as chemotherapy, such as carboplatin and vincristine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether selumetinib works better in treating patients with NF1-associated low-grade glioma compared to standard therapy with carboplatin and vincristine.
Recruiting2 awards Phase 328 criteria
Selumetinib + Vinblastine
for Low-Grade Glioma
This phase III trial investigates the best dose of vinblastine in combination with selumetinib and the benefit of adding vinblastine to selumetinib compared to selumetinib alone in treating children and young adults with low-grade glioma (a common type of brain cancer) that has come back after prior treatment (recurrent) or does not respond to therapy (progressive). Selumetinib is a drug that works by blocking a protein that lets tumor cells grow without stopping. Vinblastine blocks cell growth by stopping cell division and may kill cancer cells. Giving selumetinib in combination with vinblastine may work better than selumetinib alone in treating recurrent or progressive low-grade glioma.
Recruiting2 awards Phase 339 criteria
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Frequently asked questions
What kind of research happens at East Tennessee Childrens Hospital?
East Tennessee Childrens Hospital is a medical facility located in Knoxville, Tennessee. This center is recognized for care of Leukemia, Tumors, Sarcoma, Brain Tumor, Lymphoma and other specialties. East Tennessee Childrens Hospital is involved with conducting 211 clinical trials across 346 conditions. There are 2 research doctors associated with this hospital, such as Susan E. Spiller and Ray C. Pais.