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HALIFAX

IWK Health Centre

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HALIFAX, Nova Scotia B3K 6R8

Global Leader in Leukemia

Global Leader in Brain Tumor

Conducts research for Acute Lymphoblastic Leukemia

Conducts research for Cancer

Conducts research for Neuroblastoma

311 reported clinical trials

11 medical researchers

Photo of IWK Health Centre in HALIFAXPhoto of IWK Health Centre in HALIFAXPhoto of IWK Health Centre in HALIFAX

Summary

IWK Health Centre is a medical facility located in HALIFAX, Nova Scotia. This center is recognized for care of Leukemia, Brain Tumor, Acute Lymphoblastic Leukemia, Cancer, Neuroblastoma and other specialties. IWK Health Centre is involved with conducting 311 clinical trials across 502 conditions. There are 11 research doctors associated with this hospital, such as Craig Erker, Jennifer Foster, MD, Adam Huber, MD, and Anthony Otley.

Area of expertise

1

Leukemia

Global Leader

IWK Health Centre has run 37 trials for Leukemia. Some of their research focus areas include:

NTRK1 positive
NTRK positive
ABL-class fusions positive
2

Brain Tumor

Global Leader

IWK Health Centre has run 33 trials for Brain Tumor. Some of their research focus areas include:

Stage II
Stage I
Stage IV

Top PIs

Clinical Trials running at IWK Health Centre

Brain Tumor

Testicular cancer

Wilms Tumor

Crohn's Disease

Neuroblastoma

Acute Lymphoblastic Leukemia

Burkitt Lymphoma

Ovarian Carcinoma

Ovarian Tumors

Testicular Carcinoma

Image of trial facility.

Selumetinib vs. Chemotherapy

for Brain Cancer

This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.

Recruiting

2 awards

Phase 3

Image of trial facility.

Chemotherapy + Radiation Therapy

for Brain Cancer

This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients who did not respond to induction chemotherapy. Chemotherapy drugs, such as carboplatin, etoposide, ifosfamide, and thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays or high-energy protons to kill tumor cells and shrink tumors. Studies have shown that patients with newly-diagnosed localized NGGCT, whose disease responds well to chemotherapy before receiving radiation therapy, are more likely to be free of the disease for a longer time than are patients for whom the chemotherapy does not efficiently eliminate or reduce the size of the tumor. The purpose of this study is to see how well the tumors respond to induction chemotherapy to decide what treatment to give next. Some patients will be given RT to the spine and a portion of the brain. Others will be given high dose chemotherapy and a stem cell transplant before RT to the whole brain and spine. Giving treatment based on the response to induction chemotherapy may lower the side effects of radiation in some patients and adjust the therapy to a more efficient one for other patients with localized NGGCT.

Recruiting

1 award

Phase 2

Image of trial facility.

Lower Radiotherapy Dose

for Brain Tumors

This phase II trial studies how well lower dose radiotherapy after chemotherapy (Carboplatin \& Etoposide) works in treating children with central nervous system (CNS) germinomas. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. Researchers want to see if lowering the dose of standard radiotherapy (RT) after chemotherapy can help get rid of CNS germinomas with fewer long-term side effects.

Recruiting

1 award

Phase 2

10 criteria

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