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Kaiser Permanente Northwest
Claim this profileClackamas, Oregon 97015
Conducts research for Aortic Valve Stenosis
Conducts research for Pathologic Constriction
Conducts research for Calcific Aortic Stenosis
Conducts research for Aortic Stenosis
Conducts research for Coronary Artery Stenosis
3 reported clinical trials
0 medical researchers
Summary
Kaiser Permanente Northwest is a medical facility located in Clackamas, Oregon. This center is recognized for care of Aortic Valve Stenosis, Pathologic Constriction, Calcific Aortic Stenosis, Aortic Stenosis, Coronary Artery Stenosis and other specialties. Kaiser Permanente Northwest is involved with conducting 3 clinical trials across 9 conditions. There are 0 research doctors associated with this hospital, such as .Top PIs
Clinical Trials running at Kaiser Permanente Northwest
Aortic Valve Stenosis
Pathologic Constriction
Calcific Aortic Stenosis
Aortic Stenosis
Coronary Artery Stenosis
Coronary Heart Disease
Myocardial Ischemia
Coronary Artery Disease
TAVR
for Aortic Stenosis
This trial tests advanced heart valves that can be inserted without open-heart surgery in patients with a narrowed and stiff aortic valve due to calcium buildup. The new valve is placed through a small cut and guided to the heart, where it replaces the damaged valve. This minimally invasive procedure has recently become the only lifesaving solution for patients who cannot tolerate standard surgical valve replacement.
Recruiting1 award N/A4 criteria
PCI vs Medical Management
for Aortic Stenosis
Patients undergoing transcatheter aortic valve replacement (TAVR) often have concomitant coronary artery disease (CAD) which may adversely affect prognosis. There is uncertainty about the benefits and the optimal timing of revascularization for such patients. There is currently clinical equipoise regarding the management of concomitant CAD in patients undergoing TAVR. Some centers perform routine revascularization with percutaneous coronary intervention (PCI) (either before or after TAVR), while others follow an alternative strategy of medical management. The potential benefits and optimal timing of PCI in these patients are unknown. As TAVR expands to lower risk patients, and potentially becomes the preferred therapy for the majority of patients with severe aortic stenosis, the optimal management of concomitant coronary artery disease will be of increasing importance. The COMPLETE TAVR study will determine whether, on a background of guideline-directed medical therapy, a strategy of complete revascularization involving staged PCI using drug eluting stents to treat all suitable coronary artery lesions is superior to a strategy of medical therapy alone in reducing the composite outcome of Cardiovascular Death, new Myocardial Infarction, Ischemia-driven Revascularization or Hospitalization for Unstable Angina or Heart Failure. The study will be a randomized, multicenter, open-label trial with blinded adjudication of outcomes. Patients will be screened and consented for elective transfemoral TAVR and randomized within 96 hours of successful balloon expandable TAVR. Complete Revascularization: Staged PCI using third generation drug eluting stents to treat all suitable coronary artery lesions in vessels that are at least 2.5 mm in diameter and that are amenable to treatment with PCI and have a ≥70% visual angiographic diameter stenosis. Staged PCI can occur any time from 1 to 45 days post successful transfemoral TAVR. Vs. Medical Therapy Alone: No further revascularization of coronary artery lesions. All patients, regardless of randomized treatment allocation, will receive guideline-directed medical therapy consisting of risk factor modification and use of evidence-based therapies. The COMPLETE TAVR study will help address the current lack of evidence in this area. It will likely impact both the global delivery of health care and the management and clinical outcomes of all patients undergoing TAVR with concomitant CAD.
Recruiting1 award N/A4 criteria
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Frequently asked questions
What kind of research happens at Kaiser Permanente Northwest?
Kaiser Permanente Northwest is a medical facility located in Clackamas, Oregon. This center is recognized for care of Aortic Valve Stenosis, Pathologic Constriction, Calcific Aortic Stenosis, Aortic Stenosis, Coronary Artery Stenosis and other specialties. Kaiser Permanente Northwest is involved with conducting 3 clinical trials across 9 conditions. There are 0 research doctors associated with this hospital, such as .