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Nemours Children's Hospital
Claim this profileOrlando, Florida 32827
Global Leader in Leukemia
Global Leader in Tumors
Conducts research for Brain Tumor
Conducts research for Recurrence
Conducts research for Lymphoblastic Leukemia-Lymphoma
289 reported clinical trials
7 medical researchers
Summary
Nemours Children's Hospital is a medical facility located in Orlando, Florida. This center is recognized for care of Leukemia, Tumors, Brain Tumor, Recurrence, Lymphoblastic Leukemia-Lymphoma and other specialties. Nemours Children's Hospital is involved with conducting 289 clinical trials across 431 conditions. There are 7 research doctors associated with this hospital, such as Scott M. Bradfield, Ramamoorthy Nagasubramanian, Emi H. Caywood, and Mary Toth, MD.Area of expertise
1Leukemia
Global LeaderStage II
Philadelphia chromosome positive
NTRK1 positive
2Tumors
Global LeaderStage IV
Stage I
Stage II
Top PIs
Scott M. BradfieldAlfred I duPont Hospital for Children7 years of reported clinical research
Expert in Brain Tumor
Expert in Tumors
43 reported clinical trials
79 drugs studied
Ramamoorthy NagasubramanianNemours Children's Clinic-Jacksonville3 years of reported clinical research
Studies Tumors
Studies Neuroblastoma
28 reported clinical trials
62 drugs studied
Emi H. CaywoodAlfred I duPont Hospital for Children5 years of reported clinical research
Expert in Leukemia
Studies Lymphoblastic Leukemia-Lymphoma
23 reported clinical trials
63 drugs studied
Mary Toth, MDNemours Children's Health1 year of reported clinical research
Studies Arthritis
Studies Spondyloarthritis
4 reported clinical trials
5 drugs studied
Clinical Trials running at Nemours Children's Hospital
Brain Tumor
Germ Cell Tumors
Osteosarcoma
Langerhans Cell Histiocytosis
Rhabdomyosarcoma
Non-Hodgkin's Lymphoma
Acute Lymphoblastic Leukemia
Astrocytoma
Acute Myeloid Leukemia
Acute Leukemia
Selumetinib vs Carboplatin/Vincristine
for Brain Cancer
This phase III trial studies if selumetinib works just as well as the standard treatment with carboplatin/vincristine (CV) for subjects with NF1-associated low grade glioma (LGG), and to see if selumetinib is better than CV in improving vision in subjects with LGG of the optic pathway (vision nerves). Selumetinib is a drug that works by blocking some enzymes that low-grade glioma tumor cells need for their growth. This results in killing tumor cells. Drugs used as chemotherapy, such as carboplatin and vincristine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether selumetinib works better in treating patients with NF1-associated low-grade glioma compared to standard therapy with carboplatin and vincristine.
Recruiting2 awards Phase 328 criteria
Selumetinib vs. Chemotherapy
for Brain Cancer
This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.
Recruiting2 awards Phase 3
Selumetinib + Vinblastine
for Low-Grade Glioma
This phase III trial investigates the best dose of vinblastine in combination with selumetinib and the benefit of adding vinblastine to selumetinib compared to selumetinib alone in treating children and young adults with low-grade glioma (a common type of brain cancer) that has come back after prior treatment (recurrent) or does not respond to therapy (progressive). Selumetinib is a drug that works by blocking a protein that lets tumor cells grow without stopping. Vinblastine blocks cell growth by stopping cell division and may kill cancer cells. Giving selumetinib in combination with vinblastine may work better than selumetinib alone in treating recurrent or progressive low-grade glioma.
Recruiting2 awards Phase 339 criteria
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Frequently asked questions
What kind of research happens at Nemours Children's Hospital?
Nemours Children's Hospital is a medical facility located in Orlando, Florida. This center is recognized for care of Leukemia, Tumors, Brain Tumor, Recurrence, Lymphoblastic Leukemia-Lymphoma and other specialties. Nemours Children's Hospital is involved with conducting 289 clinical trials across 431 conditions. There are 7 research doctors associated with this hospital, such as Scott M. Bradfield, Ramamoorthy Nagasubramanian, Emi H. Caywood, and Mary Toth, MD.