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Northwestern University Feinberg School of Medicine
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Chicago, Illinois 60611
Global Leader in HIV Infection
Global Leader in Human Immunodeficiency Virus Infection
Conducts research for AIDS
Conducts research for Cancer
Conducts research for Breast Cancer
491 reported clinical trials
41 medical researchers
Summary
Northwestern University Feinberg School of Medicine is a medical facility located in Chicago, Illinois. This center is recognized for care of HIV Infection, Human Immunodeficiency Virus Infection, AIDS, Cancer, Breast Cancer and other specialties. Northwestern University Feinberg School of Medicine is involved with conducting 491 clinical trials across 575 conditions. There are 41 research doctors associated with this hospital, such as Sunandana Chandra, Amy Paller, Thomas Schnitzer, and Devalingam Mahalingam, MBBChBAO.
Top PIs
Sunandana Chandra
Northwestern University
3 years of reported clinical research
Amy Paller
Northwestern University
8 years of reported clinical research
Thomas Schnitzer
Northwestern University
2 years of reported clinical research
Devalingam Mahalingam, MBBChBAO
Northwestern University
7 years of reported clinical research
Clinical Trials running at Northwestern University Feinberg School of Medicine
Peripheral Vascular Disease
Intermittent Claudication
Cancer
Limited Mobility
Peripheral Artery Disease
Peripheral Arterial Disease
Atopic Dermatitis
Hidradenitis Suppurativa
Breast Cancer
Osteoarthritis
SMART Exercise
for Peripheral Arterial Disease
Supervised exercise therapy (SET), consisting of treadmill exercise conducted three times weekly at a center while supervised by healthcare personnel, is first line therapy for people disabled by lower extremity peripheral artery disease (PAD). However, travelling three times/week to a center for SET is burdensome. Compared to SET, home-based exercise is more accessible and less burdensome. Yet, evidence-based guidelines recommend SET over home-based exercise for PAD. Walking exercise is first line therapy to improve walking distance for PAD, but it does not eliminate ischemic leg symptoms in most people with PAD. The investigators' work and that of others showed that nitrate-rich beetroot juice, which increases plasma nitrite, limb perfusion, and skeletal muscle function, significantly improved exercise tolerance and reduced non-response to exercise in people with and without PAD. The investigators will use a 2 x 2 factorial design to address two major barriers to achieving benefits from exercise therapy for PAD: First, guideline recommendations for supervised exercise therapy (SET) as first line therapy for PAD. Second, the inability of exercise therapy to eliminate PAD-related disability in most people with PAD. Participants will be randomized to one of four groups for 12 weeks: Supervised treadmill exercise + nitrate rich beetroot juice; supervised treadmill exercise + placebo, home-based walking exercise + nitrate rich beetroot juice, home-based walking exercise + placebo.
Recruiting
1 award
Phase 3
2 criteria
Exercise and Beetroot Juice
for Peripheral Arterial Disease
Lower extremity revascularization combined with supervised exercise significantly improves walking performance compared to revascularization alone in people who have PAD without limb threatening ischemia. However, supervised exercise is inaccessible or burdensome for most PAD patients. Investigators hypothesize that home-based exercise combined with lower extremity revascularization will significantly improve walking performance compared to revascularization alone in patients with PAD undergoing revascularization for disabling PAD. Investigators further hypothesize that inorganic nitrate, a major source of nitric oxide (NO) abundant in beetroot juice, will improve walking performance after lower extremity revascularization, compared to placebo. In preclinical models, NO inhibits inflammation, neointimal hyperplasia, thrombosis, and vascular smooth muscle cell migration at sites of revascularization. NO increases angiogenesis and perfusion, repairs skeletal muscle damaged by ischemia, and stimulates mitochondrial activity. In a randomized clinical trial with a 2 x 2 factorial design, the trial will test the following two primary hypotheses in 386 patients randomized within three months of a successful lower extremity revascularization for disabling PAD: First, that home-based exercise combined with lower extremity revascularization will improve six-minute walk distance more than revascularization alone at 6-month follow-up (Primary Aim #1). Second, that nitrate-rich beetroot juice combined with lower extremity revascularization will improve six-minute walk, compared to placebo combined with revascularization at 6-month follow-up (Primary Aim #2).
Recruiting
1 award
Phase 3
1 criteria
Fisetin
for PAD
The investigators propose a pilot randomized trial to gather preliminary data to test the hypothesis that Fisetin will reduce abundance of senescent cells in blood, skeletal muscle, and both subcutaneous and inter muscular adipose tissue and improve 6-minute walk distance in 34 people with peripheral artery disease (PAD). the investigators will determine whether greater declines in abundance of cells with senescent markers are associated with greater improvement in 6-minute walk distance in people with peripheral artery disease. In exploratory analyses, the investigators will assess whether Fisetin reduces interleukin-6 (IL-6) and novel senescent markers in adipose tissue, muscle, and/or blood.
Recruiting
0 awards
Phase 2
2 criteria
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Frequently asked questions
What kind of research happens at Northwestern University Feinberg School of Medicine?
Northwestern University Feinberg School of Medicine is a medical facility located in Chicago, Illinois. This center is recognized for care of HIV Infection, Human Immunodeficiency Virus Infection, AIDS, Cancer, Breast Cancer and other specialties. Northwestern University Feinberg School of Medicine is involved with conducting 491 clinical trials across 575 conditions. There are 41 research doctors associated with this hospital, such as Sunandana Chandra, Amy Paller, Thomas Schnitzer, and Devalingam Mahalingam, MBBChBAO.
Where is Northwestern University Feinberg School of Medicine located?
The Northwestern University Feinberg School of Medicine, situated in downtown Chicago at 420 E. Superior St., is part of the Northwestern Memorial Hospital complex. The Feinberg Pavilion, offering inpatient care services and private patient rooms, is located at 251 E. Huron St. Both locations are easily accessible by public transportation.
Who should I call to ask about financial aid or insurance network?
**Northwestern University's Feinberg School of Medicine Financial Assistance** - **Hospital Financial Assistance:** Contact the Financial Aid Experts at 312-503-1923 or via email at cgonzalez@northwestern.edu. - **Insurance Inquiries:** Reach out to Student Health Insurance at 312-503-1242 for the Chicago Campus or 847-491-3621 for the Evanston Campus. - **Northwestern Medicine's Financial Assistance Program:** Call 800.423.0523 (TTY: 711) or visit [nm.org/financialassistance](http://nm.org/financialassistance) for more information.
What insurance does Northwestern University Feinberg School of Medicine accept?
Northwestern University Feinberg School of Medicine and its affiliated hospitals accept a broad range of insurance plans, including commercial, government, exchange arenas, and Medicare assignment. For US-based faculty and staff, Northwestern offers four Blue Cross Blue Shield medical plans and an ACA Value PPO option, while Qatar-based faculty and staff have access to the Cigna International Health plan. All full-time students must maintain health insurance through the university-contracted Aetna Insurance Company, with the NU-SHIP being mandatory for international students holding a J-1 or F-1 U.S. visa.
What awards or recognition has Northwestern University Feinberg School of Medicine received?
Northwestern University Feinberg School of Medicine, located in Chicago, Illinois, is recognized as a top 20 medical school, receiving $706 million in awards for the 2022-2023 academic year, with $477 million from the National Institutes of Health (NIH). This funding places Feinberg 15th in NIH funding rankings among all American Medical Schools. The school excels in various medical specialties, ranking highly in Physical Medicine and Rehabilitation (1), Public Health (1), Urology (2), Obstetrics and Gynecology (3), Dermatology (4), Anatomy/Cell Biology (7), Neurology (7), Neuroscience (9), Surgery (10), Neurosurgery (11), Internal Medicine (16), Pharmacology (17), and Microbiology, Immunology and Virology (20).
Unbiased Results
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Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.