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The University of Kansas Cancer Center, Lee's Summit Clinic
Claim this profileLees Summit, Missouri 64064
Conducts research for Breast Cancer
Conducts research for Non-Small Cell Lung Cancer
Conducts research for Lung Cancer
5 reported clinical trials
0 medical researchers
Summary
The University of Kansas Cancer Center, Lee's Summit Clinic is a medical facility located in Lees Summit, Missouri. This center is recognized for care of Breast Cancer, Non-Small Cell Lung Cancer, Lung Cancer and other specialties. The University of Kansas Cancer Center, Lee's Summit Clinic is involved with conducting 5 clinical trials across 3 conditions. There are 0 research doctors associated with this hospital, such as .Area of expertise
1Breast Cancer
HER2
multifocal/multicentric
ER
2Non-Small Cell Lung Cancer
Stage II
Stage I
Stage III
Top PIs
Clinical Trials running at The University of Kansas Cancer Center, Lee's Summit Clinic
Non-Small Cell Lung Cancer
Lung Cancer
Hypo-fractionated vs Standard IMRT with Chemotherapy and Immunotherapy
for Non-Small Cell Lung Cancer
The hypothesis for this study is that hypofractionated IMRT to 62.5 Gy in 25 fractions (2.5 Gy/fraction) with concurrent carboplatin and paclitaxel, followed by maintenance durvalumab will improve locoregional control at 18 months by 10% compared to standard-fractionated chemo-IMRT/durvalumab. A modest improvement in locoregional control (LRC) was selected as a target which could merit further study of this hypofractionated IMRT regimen in a Phase III trial
Recruiting1 award Phase 211 criteria
Ipatasertib + Docetaxel
for Non-Small Cell Lung Cancer
For metastatic/advanced NSCLC patients who do not have targetable mutations, either immunotherapy targeting the programmed death-1 and its ligand (PD-1/L1) pathway alone or in combination with platinum doublet chemotherapy is now a standard of care. However, still about half of the patients do not benefit due to treatment resistance. It is therefore critically important to find novel therapies and combinations to benefit patients who have failed or are intolerant to 1st line immunotherapy. This study hypothesizes that ipatasertib in combination with taxane (e.g. docetaxel) can be an effective strategy. Ipatasertib is a novel adenosine triphosphate (ATP)-competitive inhibitor that has demonstrated robust and selective targeting of protein kinase B (PKB, also known as AKT) in cancer patients. Importantly, evidence from preclinical studies has demonstrated that AKT inhibitors (e.g. ipatasertib) can enhance the therapeutic effect of chemotherapy as well as immunotherapy via modulating Phosphatidylinositol 3-kinase (PI3'K)-AKT activity.
Recruiting1 award Phase 210 criteria
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Frequently asked questions
What kind of research happens at The University of Kansas Cancer Center, Lee's Summit Clinic?
The University of Kansas Cancer Center, Lee's Summit Clinic is a medical facility located in Lees Summit, Missouri. This center is recognized for care of Breast Cancer, Non-Small Cell Lung Cancer, Lung Cancer and other specialties. The University of Kansas Cancer Center, Lee's Summit Clinic is involved with conducting 5 clinical trials across 3 conditions. There are 0 research doctors associated with this hospital, such as .