Procedure
ADX-914 for Severe Alopecia Areata
This trial tests ADX-914, an injectable medication, in adults with severe hair loss due to Alopecia Areata. The treatment likely works by calming the immune system to help hair grow back. Delgocitinib has shown effectiveness in other inflammatory skin conditions and is being explored for its potential in treating alopecia areata.
Dihydroorotate Dehydrogenase Inhibitor
Farudodstat Tablets for Alopecia Areata
This trial is testing farudodstat, a medication that may help people with significant hair loss due to Alopecia Areata. The study focuses on adults who have lost 30% or more of their scalp hair. Farudodstat works by influencing body processes that control hair growth.
Scalp Cooling for Breast Cancer
This trial is testing if the Paxman Scalp Cooling System can prevent hair loss in people with advanced breast cancer who are receiving specific treatments. The cooling system works by lowering the scalp temperature to protect hair from the effects of these treatments. The Paxman Scalp Cooling System has been studied in multiple trials and shown to be effective in reducing treatment-induced hair loss in breast cancer patients.
Stem Cell Therapy
Stem Cell Educator Therapy for Alopecia Areata
This trial is testing a new treatment called Stem Cell Educator therapy for people with alopecia areata, a condition that causes hair loss. The treatment uses the patient's own immune cells exposed to stem cells to help reset the immune system. It targets patients who haven't had success with other treatments. Stem Cell Educator therapy involves circulating a patient's blood through a system that allows immune cells to interact with stem cells, aiming to reset the immune system.
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Trials for Alopecia Patients
Janus Kinase (JAK) Inhibitor
Upadacitinib for Severe Alopecia Areata
This trial is testing upadacitinib, a medication that may help people with severe hair loss due to alopecia areata. The drug works by stopping the immune system from attacking hair roots. Adolescents and adults with severe alopecia areata are participating to see if this treatment is safe and effective.
Monoclonal Antibodies
Dupilumab for Alopecia Areata
This trial tests a new treatment for children and adolescents with significant hair loss due to Alopecia Areata. The treatment likely helps the immune system stop attacking hair follicles, allowing hair to regrow. Oral tofacitinib has shown promising results in treating alopecia areata in children.
Janus Kinase (JAK) Inhibitor
Ruxolitinib for Alopecia Areata
This trial tests if ruxolitinib, a pill that calms the immune system, can help people with APECED and severe hair loss. The medication works by blocking overactive immune signals, which may reduce body attacks and promote hair regrowth. Ruxolitinib has shown promise in treating severe alopecia areata by inducing hair regrowth in patients.
Phase 3 Trials
Janus Kinase (JAK) Inhibitor
Upadacitinib for Severe Alopecia Areata
This trial is testing upadacitinib, a medication that may help people with severe hair loss due to alopecia areata. The drug works by stopping the immune system from attacking hair roots. Adolescents and adults with severe alopecia areata are participating to see if this treatment is safe and effective.
JAK Inhibitor
PF-06651600 for Alopecia Areata
This trial is testing a new drug to treat alopecia areata, which is an autoimmune disease that causes hair loss. The trial is open-label, which means all patients will receive the active drug. There is also a sub-study evaluating the immune response to vaccines in patients who have received the drug for at least 6 months.
JAK Inhibitor
CTP-543 for Alopecia Areata
This trial is testing CTP-543, a medication that may help people regrow hair by stopping the immune system from attacking hair follicles. It focuses on adults with chronic, moderate to severe alopecia areata. CTP-543 has shown promise in treating this condition.
Janus Kinase (JAK) Inhibitor
Baricitinib for Pediatric Hair Loss
This trial is testing baricitinib, a medication that may help treat severe hair loss. It targets children aged 6 to less than 18 years who have significant hair loss. The medication works by reducing the immune system's activity that causes hair loss.
Janus Kinase (JAK) Inhibitor
Baricitinib for Alopecia Areata
This trial is testing baricitinib to see if it is safe and effective for adults with severe hair loss due to alopecia areata. The drug works by calming the immune system to prevent it from attacking hair follicles. Baricitinib was approved by the FDA for treating severe alopecia areata.
Trials With No Placebo
Janus Kinase (JAK) Inhibitor
Ruxolitinib for Alopecia Areata
This trial tests if ruxolitinib, a pill that calms the immune system, can help people with APECED and severe hair loss. The medication works by blocking overactive immune signals, which may reduce body attacks and promote hair regrowth. Ruxolitinib has shown promise in treating severe alopecia areata by inducing hair regrowth in patients.
JAK Inhibitor
PF-06651600 for Alopecia Areata
This trial is testing a new drug to treat alopecia areata, which is an autoimmune disease that causes hair loss. The trial is open-label, which means all patients will receive the active drug. There is also a sub-study evaluating the immune response to vaccines in patients who have received the drug for at least 6 months.
JAK Inhibitor
CTP-543 for Alopecia Areata
This trial is testing CTP-543, a medication that may help people regrow hair by stopping the immune system from attacking hair follicles. It focuses on adults with chronic, moderate to severe alopecia areata. CTP-543 has shown promise in treating this condition.
Cellular Regenerative Treatment
Cell + Plasma Therapy for Hair Loss
This trial is testing a new mixture of cells and plasma to see if it is safe and effective in treating hair loss. The mixture will be compared to a similar mixture and to a control group who will receive a standard treatment.
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Frequently Asked Questions
Introduction to alopecia areata
What are the top hospitals conducting alopecia areata research?
When it comes to advancements in the field of alopecia areata research, several top hospitals across the United States are making significant strides. In Tampa, ForCare Clinical Research is actively involved in five clinical trials focused on this condition, with a total of eight trials conducted thus far. Notably, their first recorded trial took place in 2018. Meanwhile, the Icahn School of Medicine at Mount Sinai in New york has also been dedicated to studying alopecia areata and currently has five ongoing trials in progress. With a history of 15 completed trials since their first one in 2015, they have become an important center for advancing our understanding of this hair loss disorder.
In Indianapolis, Dawes Fretzin Clinical Research Group is contributing to alopecia areata research through four active clinical trials and a total count of ten previous studies. They joined forces with patients as early as 2016 to begin investigating potential treatments for this condition. Investigate MD located in Scottsdale may have fewer active clinical trials - three currently - but they too play an essential role by building upon the knowledge gained from their four previously conducted alopecia areata investigations since recording their initial trial just two years ago.
Lastly but certainly not least important is DS Research situated within Louisville; despite having three active projects related specifically towards Alopecia Areata which helps them make invaluable contributions into bettering treatment pathways available against such conditions through conducting prior experiments summing up tilldate so far counting upto about five studies beginning most lately only during2018.
These hospitals represent beacons of hope for those affected by alopecia areata—a condition characterized by sudden hair loss—and demonstrate the dedication and commitment among medical professionals nationwide who strive to find effective treatments and potential cures. Through these collaborative efforts across various locations throughout America's healthcare landscape emerges confidence that every study undertaken brings us closer towards combating this challenging disorder more effectively while providing much-needed relief for individuals living with alopecia areata.
Which are the best cities for alopecia areata clinical trials?
When it comes to alopecia areata clinical trials, several cities emerge as frontrunners in research and development. Portland, Oregon leads the pack with 12 active trials investigating treatments like Baricitinib, Deucravacitinib Dose 1, and CTP-543. Minneapolis, Minnesota closely follows with 11 ongoing studies focused on innovative approaches such as PF-06651600, Baricitinib, and Farudodstat. San Antonio, Texas also boasts 11 active trials examining treatment options like CTP-543, Deucravacitinib Dose 1, and Daxdilimab. New Haven in Connecticut hosts 10 active trials exploring interventions including Deucravacitinib Dose 1,P F-06651600,and Baricitinib.Other notable city is Tampa Florida where there are currently9active Trials studyingDeucravacitinibDose 1 ,BaricitiniandCTP/543.These cities provide individuals dealing with alopecia areata access to cutting-edge clinical trials that pave the way for advancements in care and bring hope for better treatment outcomes
Which are the top treatments for alopecia areata being explored in clinical trials?
Exciting advancements in the field of alopecia areata have led to the exploration of several cutting-edge treatments in clinical trials. PF-06651600, with three active trials and four all-time alopecia areata trials since its introduction in 2016, stands out as a promising option. Additionally, baricitinib and dupilumab show great potential, each undergoing two active trials while accumulating three all-time alopecia areata trials since being listed in 2018. An upcoming treatment called farudodstat is also making waves with one ongoing trial and being introduced for the first time in 2023. These innovative therapies offer hope for individuals suffering from alopecia areata by potentially providing effective solutions for this challenging condition.
What are the most recent clinical trials for alopecia areata?
Exciting advancements are being made in the field of alopecia areata treatment, with recent clinical trials showcasing promising potential for patients. Among these trials is ADX-914, an experimental drug currently in Phase 2. Additionally, farudodstat, dupilumab, oral minoxidil, and TDM-105795 topical solution have also shown positive results in Phase 2 studies. These developments offer hope to individuals suffering from alopecia areata and may pave the way for more effective treatments in the future.
What alopecia areata clinical trials were recently completed?
Exciting developments have recently emerged in the field of alopecia areata, with several clinical trials achieving completion and offering potential solutions for those affected by this autoimmune condition. In April 2022, LEO Pharma successfully concluded a trial exploring the efficacy of Delgocitinib cream. Technoderma Medicines Inc., on the other hand, completed two separate trials involving TDM-105795 in February 2022 and April 2021 respectively. Concert Pharmaceuticals' CTP-543 trial reached its endpoint in February 2021, while Pfizer's investigation into Etrasimod wrapped up in July 2020. Additionally, the University of Arizona conducted a trial examining Keratinocyte growth factor which concluded its study phase back in April 2020. These recent advancements highlight ongoing efforts to find effective treatments for alopecia areata and offer hope to individuals grappling with hair loss caused by this challenging condition.