Amyloidosis Clinical Trials 2024

What are the top hospitals conducting amyloidosis research?

In the realm of medical research, clinical trials are vital for advancing our understanding and treatment options for various conditions. When it comes to amyloidosis, a rare disease characterized by the build-up of abnormal proteins in organs and tissues, several top hospitals are leading the way. In Portland, Oregon Health & Science University stands out with eight ongoing amyloidosis trials and a cumulative total of 15 studies dedicated to this condition. Their first recorded trial took place in 2013, demonstrating their relatively recent but impactful involvement in amyloidosis research.

Meanwhile, Brigham and Women's Hospital in Boston has been actively contributing to the field as well. With seven current amyloidosis trials and a history that includes 12 conducted studies since their first trial in 2013, they continue to make strides towards better understanding this complex disease.

Further east at Detroit's Karmanos Cancer Institute, researchers are diligently conducting six active clinical trials focused on amyloidosis. Since initiating their inaugural study in 2012, they have accumulated valuable knowledge from a total of 13 past investigations.

Washington University School of Medicine located in Saint Louis is also playing its part with six ongoing amyloidosis trials. Having embarked on their first ever trial back in 2008 on this subject matter itself; over the years accumulating eleven experiments which aids significantly developing credible resources for patients suffering from such unusual ailments

At Dana-Farber Cancer Institute again situated within Boston’s vibrant medical community, five active clinical trials centered around treating or managing amyloidosis are being carried out presently along with an additional seven previously held investigations since pioneering into this field dating all the way back until1996 thus serving as an essential resource for both doctors and patients alike seeking promising solutions against dreading ailment like Amyloidsis

These top hospitals' dedication to expanding our knowledge base through rigorous research serves not only those currently affected by amyloidosis but builds foundations for future advancements that might benefit countless patients worldwide. Each trial, no matter how small it may seem, contributes to the greater body of knowledge that brings us closer to effective treatments and better quality of life for those living with amyloidosis.

Which are the best cities for amyloidosis clinical trials?

When it comes to amyloidosis clinical trials, several cities emerge as leading centers of research and innovation. Boston, Massachusetts takes the lead with 45 active trials focused on promising treatments like CAEL-101, Daratumumab, and Eplontersen. New york City follows closely behind with 36 ongoing studies exploring similar therapies. Rochester, Minnesota is also a prominent city in this field with 22 active trials investigating treatment options such as CAEL-101 and Tafamidis. Additionally, Portland, Oregon shows promise with 19 active trials examining Eplontersen, CAEL-101, and more. Lastly, Detroit Michigan also plays a significant role in these clinical trials with its participation in 16 studies that explore potential treatments for amyloidosis like CAEL-101 and Daratumumab.

Which are the top treatments for amyloidosis being explored in clinical trials?

Exciting advancements in clinical trials offer hope for the treatment of amyloidosis. Among the top contenders are CAEL-101, displaying promise in three active and three all-time trials since its introduction in 2020. Eplontersen is also gaining attention, with three ongoing trials and four total studies dedicated to amyloidosis since 2020. Additionally, daratumumab has shown potential through two active and eleven all-time trials since 2016. Another promising option is ixazomib, which is being tested in two current and six all-time amyloidosis trials after its listing in 2011. Finally, isatuximab rounds out the list with two active and four overall trials conducted since its debut in 2018—each trial bringing us closer to finding effective treatments for this challenging condition.

What are the most recent clinical trials for amyloidosis?

Exciting advances are being made in the field of amyloidosis, as recent clinical trials offer hope for improved treatment options. One notable study is investigating an on-off sequence approach to managing amyloidosis. This innovative strategy aims to optimize patient outcomes by carefully timing treatment regimens. Additionally, a trial examining the efficacy of AMDX-2011P 50 mg holds promise for individuals affected by this condition. Another investigation focuses on venetoclax, exploring its potential benefits in treating amyloidosis patients. Furthermore, Phase 2 research evaluates the effectiveness of daratumumab cycles as part of Arm I therapy for amyloidosis management. Lastly, a study investigates dosimetry estimation and biodistribution patterns using 99mTc-p5+14 in healthy subjects with amyloidosis—an essential step towards improving diagnosis and monitoring techniques. These ongoing studies offer considerable optimism for those battling against amyloidosis and may provide vital breakthroughs in future treatments.

What amyloidosis clinical trials were recently completed?

Recent advancements in amyloidosis research have seen the completion of several notable clinical trials. In March 2022, a trial sponsored by Columbia University investigated the potential of Empagliflozin in addressing this complex condition. Another significant study, conducted by Ionis Pharmaceuticals, Inc., concluded their investigation into Eplontersen in January 2020. Additionally, Eidos Therapeutics completed a trial for acoramidis back in March 2019. These collective efforts highlight the ongoing dedication to finding effective treatments and management strategies for amyloidosis patients.