Popular Trials
BTK Inhibitor
Chemo-immunotherapy for Pediatric Brain Cancer
This trial tests a new treatment combining two drugs, ibrutinib and indoximod, with chemotherapy for young patients whose brain cancer has not responded to other treatments. The goal is to boost the immune system's ability to fight the cancer by blocking proteins that help cancer cells survive.
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Trials for Brain Tumor Patients
Checkpoint Inhibitor
Nivolumab for Brain Cancer
This trial will test whether the immunotherapy drug nivolumab is an effective treatment for people with rare CNS tumors by measuring the shrinkage of tumors or the amount of time it takes for the tumors to grow or spread.
Trials for Diffuse Intrinsic Pontine Glioma Patients
Alkylating agents
Maintenance Chemotherapy vs Observation for Ependymoma
This trial is studying how well maintenance chemotherapy works compared to observation following induction chemotherapy and radiation therapy in treating young patients with newly diagnosed ependymoma.
Cancer Vaccine
SurVaxM Vaccine for Brain Cancer
This trial tests the SurVaxM vaccine, which helps the immune system target and destroy cancer cells, in children and young adults with certain difficult-to-treat brain cancers. The vaccine works by teaching the immune system to recognize a protein found in cancer cells. Additional substances are used to make the immune response stronger.
Trials for BRAF Positive Patients
Monoclonal Antibodies
Triple Drug Therapy for Thyroid Cancer
This trial is testing a combo of 3 drugs to treat patients with a specific mutation in their cancer cells. The drugs work by either stopping cell growth or by helping the body's immune system attack the cancer.
Tyrosine Kinase Inhibitor
Lenvatinib + Pembrolizumab for Advanced Thyroid Cancer
This trial is studying how well lenvatinib and pembrolizumab work together to treat patients with anaplastic thyroid cancer that cannot be removed by surgery or has spread to other parts of the body.
Kinase Inhibitor
Dabrafenib + Trametinib + IMRT for Thyroid Cancer
This trial is testing whether combining dabrafenib, trametinib, and intensity modulated radiation therapy (IMRT) is more effective at treating patients with BRAF mutated anaplastic thyroid cancer than just using IMRT alone.
Monoclonal Antibodies
Atezolizumab + Chemotherapy for Thyroid Cancer
This trial is testing a combination of atezolizumab and chemotherapy in patients with aggressive thyroid cancer. The treatment aims to boost the immune system and stop cancer cell growth. Atezolizumab helps enhance the immune response against cancer cells.
Phase 3 Trials
Alkylating agents
Maintenance Chemotherapy vs Observation for Ependymoma
This trial is studying how well maintenance chemotherapy works compared to observation following induction chemotherapy and radiation therapy in treating young patients with newly diagnosed ependymoma.
Tyrosine Kinase Inhibitor
Alectinib vs Crizotinib for Non-Small Cell Lung Cancer
This trial compares two medications, alectinib and crizotinib, for treating a specific type of advanced lung cancer. The patients have not received any prior treatment for their cancer. Both drugs work by blocking a protein that helps the cancer cells grow. Alectinib has shown superior effectiveness and fewer side effects compared to crizotinib in treating this type of lung cancer.
Tyrosine Kinase Inhibitor
Soquelitinib for Peripheral T-Cell Lymphoma
This trial is comparing a new drug called soquelitinib to the standard treatment chosen by the doctor for patients with certain types of relapsed or refractory peripheral T-cell lymphoma.
Trials With No Placebo
Checkpoint Inhibitor
Nivolumab for Brain Cancer
This trial will test whether the immunotherapy drug nivolumab is an effective treatment for people with rare CNS tumors by measuring the shrinkage of tumors or the amount of time it takes for the tumors to grow or spread.
Radiation Therapy
Surgery + Re-Irradiation for Recurrent Ependymoma
This trial is for people with ependymoma that has come back after initial treatment. Surgery and re-irradiation with higher than usual doses of radiation will be used to try to treat the tumor. Tumor tissue and blood will be studied to learn more about the tumor and how it responds to treatments.
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Frequently Asked Questions
Introduction to anaplastic ependymoma
What are the top hospitals conducting anaplastic ependymoma research?
The search for effective treatments and improved outcomes in anaplastic ependymoma has led to a remarkable collaboration among leading hospitals across the United States. In New york, Memorial Sloan Kettering Cancer Center spearheads this effort with an impressive 25 ongoing clinical trials dedicated to anaplastic ependymoma, building on their extensive history of 24 completed trials since their first recorded study in 2009. On the opposite coast, Children's Hospital Los Angeles is making significant strides as well, currently conducting 20 active trials and having accomplished 23 previous studies since initiating their research journey back in 1997.
Meanwhile, Cincinnati Children's Hospital Medical Center holds a prominent position in the fight against anaplastic ependymoma with its commitment to ongoing clinical trials. With 18 active trials underway and a noteworthy tally of 27 previously conducted studies starting from their inaugural trial in 2003; it stands shoulder-to-shoulder with other esteemed institutions.
Children's Hospital Colorado also plays a vital role by actively exploring new avenues through its ongoing involvement in eighteen clinical trials related to anaplastic ependymoma. Having conducted twenty prior investigations since recording their first trial in2010; they have emerged as key contributors towards advancing our understanding of this condition.
In sunny Orlando, Arnold Palmer Hospital for Children does not fall behind either when it comes to contributing knowledge about this rare cancer subtype. With eighteen current clinical trials dedicated solely to anaplastic ependymoma and nineteen completed ones spanning over two decades since recording that historic moment backin2004; they are helping shape future treatment options for individuals affected by this challenging disease.
These top-tier medical centers located throughout the country symbolize both hope and progress within the realm of anaplastic ependymoma research. Their collective dedication exemplifies how collaboration can lead us closer to breakthroughs that hold promise for enhanced care strategies while raising optimism among patients worldwide
Which are the best cities for anaplastic ependymoma clinical trials?
When it comes to anaplastic ependymoma clinical trials, several cities in the United States offer a wealth of ongoing studies. New york City leads the way with 65 active trials exploring treatments like Pharmacological Study, Tazemetostat, Tipifarnib, and more. Orlando, Florida follows closely behind with 56 trials investigating interventions such as Pharmacological Study and 3-Dimensional Conformal Radiation Therapy. Saint Louis, Missouri also proves to be a prominent location for research with 53 active trials focusing on Pharmacological Study and Vemurafenib among others. These cities provide individuals diagnosed with anaplastic ependymoma access to cutting-edge clinical trials that contribute to advancements in treatment options and overall outcomes.
Which are the top treatments for anaplastic ependymoma being explored in clinical trials?
Exciting advancements are being made in the exploration of clinical trials for anaplastic ependymoma. Leading the charge is pembrolizumab, currently involved in four active trials dedicated to this specific type of cancer. Since its introduction in 2015, it has shown promise with one all-time trial focused on anaplastic ependymoma. Another notable treatment under investigation is a pharmacological study, making waves with three ongoing trials and a total of nine all-time studies since its inception in 2010. Additionally, ONC206 and brigatinib are emerging as potential game-changers, both participating in two active trials each and showing encouraging results thus far. As research progresses, these treatments hold immense hope for patients battling anaplastic ependymoma worldwide.
What are the most recent clinical trials for anaplastic ependymoma?
Recent clinical trials have brought hope to patients with anaplastic ependymoma, a rare and aggressive form of brain cancer. One promising study investigated the use of lorlatinib in combination with platinum and pemetrexed for treating this condition. Another trial focused on Arm A, which explored potential treatments for relapsed or refractory CNS tumors including anaplastic ependymoma. Furthermore, research has been conducted on LUTATHERA®, a targeted therapy using lutetium Lu 177 dotatate, as well as HER2 Specific CAR T Cell therapy and vudalimab. These trials mark significant advancements in our understanding of treatment options for anaplastic ependymoma, providing renewed optimism for patients and their loved ones during these challenging times.
What anaplastic ependymoma clinical trials were recently completed?
Recently completed clinical trials have made significant strides in advancing the treatment of anaplastic ependymoma. These trials represent promising developments in the field.