Popular Trials
Monoclonal Antibodies
Peresolimab for Rheumatoid Arthritis
This trial is testing a new medication called peresolimab to see if it is safe and effective for adults with moderate to severe rheumatoid arthritis. The medication aims to reduce inflammation and joint damage by calming the immune system.
Behavioural Intervention
Mobile App for Arthritis
This trial aims to test a new version of a smartphone app for arthritis over 12 months. Researchers will compare how often people visit their healthcare providers before and after using the app. They will also compare
Behavioural Intervention
Telehealth Exercise Program for Arthritis
This trial will evaluate the feasibility & acceptability of group telehealth exercise to treat lower extremity OA in Veterans over 9 months. Outcomes will measure changes in WOMAC, performance & physical activity.
Janus Kinase (JAK) Inhibitor
Upadacitinib for Juvenile Arthritis
This trial is testing a medication called upadacitinib in children with a type of arthritis that affects many joints. The study aims to see how the drug behaves in their bodies, how safe it is, and how well they can tolerate it. Upadacitinib works by reducing inflammation and pain by blocking certain enzymes in the body. It has been approved for treating rheumatoid arthritis in adults.
Popular Filters
Trials for Osteoarthritis Patients
Procedure
Partial Wrist Fusion Techniques for Wrist Arthritis
This trial is comparing two techniques for partial wrist fusion in people with arthritis caused by prior injury. One group will have a four-corner fusion, and the other group will have a three-corner or capitolunate fusion with triquetral excision.
Nonsteroidal Anti-inflammatory Drug
NSAIDs for Lyme Arthritis
This trial is testing if taking anti-inflammatory drugs regularly can help prevent long-term joint problems in people with Lyme disease. It focuses on patients who don't get better with antibiotics. The drugs work by reducing inflammation, which might stop the prolonged symptoms.
Trials for OA Patients
Procedure
Partial Wrist Fusion Techniques for Wrist Arthritis
This trial is comparing two techniques for partial wrist fusion in people with arthritis caused by prior injury. One group will have a four-corner fusion, and the other group will have a three-corner or capitolunate fusion with triquetral excision.
Vitamin
Vitamin D + Fish Oil for Health Improvement
This trial is studying whether taking daily dietary supplements of vitamin D3 or omega-3 fatty acids reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses.
Orthopedic Implant
Titanium Knee Implant for Knee Arthritis
This trial evaluates the safety and effectiveness of the Persona Ti-Nidium implant in patients needing knee replacement surgery. The implant aims to improve movement and reduce pain by replacing damaged knee parts with an artificial joint. The study will follow patients for several years to assess long-term outcomes. The Persona® system is a newly launched implant designed for total knee replacement with innovations intended for better function and higher flexibility.
Phase 3 Trials
Nonsteroidal Anti-inflammatory Drug
NSAIDs for Lyme Arthritis
This trial is testing if taking anti-inflammatory drugs regularly can help prevent long-term joint problems in people with Lyme disease. It focuses on patients who don't get better with antibiotics. The drugs work by reducing inflammation, which might stop the prolonged symptoms.
Trials With No Placebo
Procedure
Partial Wrist Fusion Techniques for Wrist Arthritis
This trial is comparing two techniques for partial wrist fusion in people with arthritis caused by prior injury. One group will have a four-corner fusion, and the other group will have a three-corner or capitolunate fusion with triquetral excision.
Nonsteroidal Anti-inflammatory Drug
NSAIDs for Lyme Arthritis
This trial is testing if taking anti-inflammatory drugs regularly can help prevent long-term joint problems in people with Lyme disease. It focuses on patients who don't get better with antibiotics. The drugs work by reducing inflammation, which might stop the prolonged symptoms.
Angiotensin II Receptor Blocker, COX-2 Inhibitor, Biguanide
Valsartan + Celecoxib + Metformin for Type 2 Diabetes
This trial is evaluating the safety, tolerability and superiority of RK-01, a valsartan plus celecoxib dual add-on to metformin-HCL XR over metformin in newly diagnosed and obese adult type 2 diabetes patients with high blood pressure, arthritis and inadequate glycemic control with metformin monotherapy, diet and exercise. The objective is to assess the effect of RK-01 on hemoglobin A1c (HbA1c) levels, beta cell function and insulin resistance with co-administration of valsartan, celecoxib and metformin-HCl X
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Frequently Asked Questions
Introduction to arthritis
What are the top hospitals conducting arthritis research?
When it comes to advancing our understanding and treatment of arthritis, several top hospitals are leading the way with their dedication to clinical trials. The Altoona Center for Clinical Research in Duncansville has made significant strides in this field, currently conducting six active arthritis trials while having completed a total of 30 trials since recording their first study in 2005. Located in Palm Desert, Desert Medical Advances is another institution making a notable impact on arthritis research, currently engaged in four ongoing trials and boasting an impressive history of 39 completed studies dating back to 2005.
Meanwhile, Health Research of Oklahoma situated in Oklahoma City has also emerged as a key player by contributing valuable insights through its four active arthritis trials and successful completion of 25 previous investigations since starting its pioneering trial series much later than others -in2008. Another renowned facility dedicated to improving the lives of those with arthritis is Brigham and Women's Hospital located right at Boston which stands equally strong concerning actively participating clinical tests(4)and having previously accomplished two dozen such experiments beginning from year2002.
Lastly yet significantly,the Hospital for Special Surgery based out New york brings its own expertise into play with four current arthritis clinical trials and completing nineteen such research endeavors until now that trace all way back upto1999.Oftentimes dubbed as "the best hospital for orthopedics" globally,this particular institute certainly exemplifies how their work extends beyond just bones but helps improve overall health outcomes too.
These hospitals serve as beacons of hope for individuals living with the challenges presented by arthritis. Their commitment to pushing boundaries through rigorous scientific investigation not only enhances our knowledge but also paves the way for innovative therapies that can alleviate pain and improve quality of life for millions around the world affected by this condition
Which are the best cities for arthritis clinical trials?
When it comes to arthritis clinical trials, several cities emerge as top contenders in research and development. Houston, Texas takes the lead with 30 active trials focusing on treatments like Upadacitinib, Baricitinib, and Lorecivivint. Chicago, Illinois follows closely behind with 26 ongoing studies examining innovative approaches such as Upadacitinib, Tofacitinib, and Certolizumab Pegol (CZP). Phoenix, Arizona and Tampa, Florida both offer promising opportunities for participants with 23 active trials each that explore treatments like Upadacitinib, Guselkumab, Peresolimab, and Risankizumab. Finally Duncansville in Pennsylvania provides access to 18 active trials investigating potential breakthroughs including Upadacitinib and Risankizumab. These cities serve as hubs for cutting-edge arthritis clinical trials that pave the way for advancements in treatment options for individuals living with this condition.
Which are the top treatments for arthritis being explored in clinical trials?
Arthritis research is driving innovation in the search for effective treatments. Upadacitinib, with its five active trials and 19 all-time arthritis trials since 2014, stands out as a top contender. Guselkumab follows closely behind with three current trials and an impressive track record of 12 previous arthritis studies since its listing in 2013. Also gaining attention is risankizumab, currently being explored in two ongoing trials after making its debut on the scene in 2019. And let's not forget about baricitinib, which has been involved in two active trials and a total of 16 arthritis studies since it was first listed back in 2007. These advancements hold promise for patients seeking relief from this chronic condition that affects millions around the world.
What are the most recent clinical trials for arthritis?
Recent clinical trials have opened up new possibilities for individuals suffering from arthritis. The Celltex-AdMSCs trial, currently in Phase 2, offers hope by exploring the potential of adipose-derived mesenchymal stem cells as a treatment option. Another promising study is investigating the effectiveness of ASA (acetylsalicylic acid) in Phase 3 trials, aiming to provide relief and improved management for arthritis patients. Additionally, GNSC-001's low dose formulation is being examined in Phase 1 trials to evaluate its safety and efficacy. The SAM Ultrasound Device and Diclofenac Patch trial has also shown promise in providing targeted pain relief for arthritis sufferers through innovative techniques. Lastly, Enhanced Implementation (EI), currently undergoing Phase 2 testing, aims to optimize existing treatments and improve outcomes for those living with arthritis. These ongoing studies bring renewed optimism to those affected by this debilitating condition.
What arthritis clinical trials were recently completed?
Several noteworthy clinical trials investigating potential treatments for arthritis have recently concluded, demonstrating the ongoing commitment to finding effective therapies for this debilitating condition. In January 2022, Takeda completed a trial evaluating NDI-034858's efficacy in managing arthritis symptoms. Another significant milestone occurred in October 2021 when Janssen Research & Development wrapped up two separate trials: one testing JNJ-67484703 and another exploring the potential of Nipocalimab. Additionally, UCB Biopharma SRL successfully completed a trial studying Certolizumab pegol back in February 2021. These recent advancements showcase the collective efforts of pharmaceutical companies and researchers in their quest to improve treatment options for individuals living with arthritis.