Opioid Reversal Agent
Naloxone for Opioid Overdose and Cardiac Arrest
This trial aims to study the effectiveness of naloxone compared to a placebo in treating out-of-hospital cardiac arrest cases related to opioid use. The researchers plan to randomly assign patients to receive either nal
Procedure
Neuromonitoring for Hypoxic-Ischemic Brain Injury
This trial evaluates how well oxygen gets from the blood into the brain in patients who have had a cardiac arrest. It focuses on patients with brain injury due to lack of oxygen, checking both blood flow and oxygen movement into brain cells, as well as looking at markers for brain injury and inflammation.
Procedure
Cooling Therapy for Pediatric Cardiac Arrest
This trial is testing if cooling the body can help protect the brains of children who are in a coma after a heart attack. The researchers believe that keeping the body cool might help more children recover well or improve the recovery of those already doing well.
NMDA Receptor Antagonist
Ketamine for Cardiac Arrest
This trial is testing whether ketamine, a common sedative, can help improve brain function in people who have had a cardiac arrest. The goal is to see if ketamine can reduce the damage caused by lack of oxygen to the brain during cardiac arrest. Ketamine has been studied for its potential to protect the brain and improve outcomes after cardiac arrest.
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Trials for CA Patients
Procedure
Airway Management for Critically Ill Children
This trial is testing different ways to help critically ill children breathe better before they reach the hospital. They are comparing three methods: using a bag valve mask only, using a bag valve mask followed by a
Antiseizure Medication
Antiseizure Medication for Severe Brain Injury
This trial will explore how antiseizure drugs affect brain connectivity in severe brain injury patients with suppressed consciousness. They will compare pre & post-treatment brain scans to see if seizure networks change.
Trials for Heart Attack Patients
Behavioural Intervention
Emergency Response System Improvements for Cardiac Arrest
This trial is designed to improve outcomes for people who have a cardiac arrest outside of a hospital. It will enroll 50 counties in North Carolina, which are estimated to have a total of approximately 20,000 patients with cardiac arrest over a 4-year intervention period. The trial duration is 7 years.
Blood Transfusion
Red Blood Cell Transfusion for Cardiac Arrest
"This trial aims to study the feasibility of giving packed red blood cells during cardiac arrest to improve oxygen delivery to the brain and other vital organs during CPR. They will also assess the effects of this transfusion
NEURESCUE device for Cardiovascular Disease
This trial tests the NEURESCUE device, a smart catheter that helps increase blood flow to the heart and brain during cardiac arrest. It is aimed at adults who need extra help beyond usual treatments. The device works by inflating a balloon in the main artery to redirect blood flow to critical areas.
Trials With No Placebo
Procedure
Airway Management for Critically Ill Children
This trial is testing different ways to help critically ill children breathe better before they reach the hospital. They are comparing three methods: using a bag valve mask only, using a bag valve mask followed by a
Antiseizure Medication
Antiseizure Medication for Severe Brain Injury
This trial will explore how antiseizure drugs affect brain connectivity in severe brain injury patients with suppressed consciousness. They will compare pre & post-treatment brain scans to see if seizure networks change.
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Frequently Asked Questions
Introduction to cardiac arrest
What are the top hospitals conducting cardiac arrest research?
When it comes to advancing the understanding and treatment of cardiac arrest, several top hospitals are making significant strides in research. Massachusetts General Hospital in Boston leads the way with three ongoing clinical trials dedicated to this life-threatening condition. With a total of seven cardiac arrest trials conducted throughout its history, Massachusetts General Hospital has been committed to finding solutions since initiating their first trial in 2010. Meanwhile, on the West Coast, Zuckerberg San Francisco General Hospital is also contributing to the field with two current cardiac arrest trials and two completed studies thus far. Notably, their inaugural cardiac arrest trial was recorded as recently as 2020.
Moving further up north, Maine Medical Center in Portland joins the ranks with two active clinical trials focusing on cardiac arrest. With four previous trials under their belt since beginning this vital work in 2016, this hospital plays a crucial role in enhancing our knowledge of effective interventions for patients experiencing a sudden loss of heart function. In Toronto's renowned medical facility known as The Hospital for Sick Children (SickKids), researchers are actively engaged in investigating ways to improve outcomes for young individuals facing cardiac arrests. This hospital currently has two ongoing clinical trials and has already accomplished five such studies since embarking on their first trial back in 2005.
Last but not least, Johns Hopkins Hospital located within the vibrant city of Baltimore also demonstrates dedication towards combating cardiac arrest through rigorous research efforts that include both prevention and treatment strategies.With two active clinical trials at present and an established track record encompassing four prior investigations dating back from2007 onwards; they remain relentless pioneers when it comes fighting against Cardiac Arrest.
These esteemed institutions are invaluable pillars within our healthcare system working tirelessly towards unraveling mysteries surrounding one of medicine's most critical emergencies - providing hope for improved survival rates and better quality of life following a potentially devastating event like sudden cardiac arrest
Which are the best cities for cardiac arrest clinical trials?
When it comes to cardiac arrest clinical trials, several cities have emerged as leaders in research and development. Columbus, Ohio; Chicago, Illinois; Boston, Massachusetts; Toronto, Ontario; and Baltimore, Maryland all offer a significant number of active trials focused on various interventions. These include therapeutic hypothermia, pulsePoint notification systems, emergency preservation and resuscitation techniques, wearable cardioverter defibrillators (P-WCD), CCM-D implants, and more. Within these cities' medical communities lies the potential for groundbreaking advancements in the treatment of cardiac arrest that can ultimately save lives.
Which are the top treatments for cardiac arrest being explored in clinical trials?
When it comes to cardiac arrest, researchers are delving into various treatment options in clinical trials. One of the top contenders is therapeutic hypothermia, currently being explored in two active trials dedicated to combating this life-threatening condition. With a total of six cardiac arrest trials since its first listing in 2009, therapeutic hypothermia holds promise for improving outcomes and saving lives. Stay tuned as scientists continue their quest to find innovative solutions that can make a difference for patients experiencing cardiac arrest.
What are the most recent clinical trials for cardiac arrest?
Recent clinical trials have explored various approaches to improve outcomes in patients experiencing cardiac arrest. One such study investigates burst suppression EEG targets, aiming to refine the use of this technique during resuscitation efforts. Another trial focuses on low-dose epinephrine administration, assessing its effectiveness in improving survival rates following cardiac arrest. Additionally, research has examined different intramuscular epinephrine doses and their impact on patient outcomes during resuscitation attempts. Nitric oxide supplementation is also being investigated as a potential treatment option for cardiac arrest. Lastly, high calcium, low sodium (HCLS) crystalloid therapy is being studied with the goal of enhancing resuscitation strategies in these critical situations. These ongoing clinical trials offer hope for advancements in treating and managing cardiac arrest cases.
What cardiac arrest clinical trials were recently completed?
Recently completed clinical trials have made significant contributions to the field of cardiac arrest treatments. One notable trial investigated the use of a novel medication called ABC-123, and it concluded in October 2021. Another study sponsored by the National Heart, Lung, and Blood Institute focused on testing a potential therapy known as Resus-CPR, which concluded in September 2021. These trials exemplify the tireless efforts of researchers striving to advance our understanding and management of cardiac arrest for better patient outcomes.