Nutritional Therapy
Zinc Treatments for Celiac Disease
This trial aims to study the effects of a zinc-optimized gluten-free diet compared to zinc supplementation on celiac patients with zinc deficiency. It will evaluate if it can normalize zinc levels and improve CeD symptoms.
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Trials for HLA Positive Patients
Janus Kinase (JAK) Inhibitor
Ritlecitinib for Celiac Disease
This trial is testing Ritlecitinib to see if it can help adults with celiac disease in remission avoid symptoms when they eat gluten. Participants will take either the drug or a non-active substance and eat a small amount of gluten regularly. The drug aims to block immune signals that cause inflammation.
DONQ52 for Celiac Disease
This trial is testing a new drug called DONQ52 in patients with well-managed celiac disease. The study has two parts: one where patients receive single doses and another where they receive multiple doses. The goal is to see if the drug is safe and well-tolerated.
Immunomodulator
TAK-101 for Celiac Disease
This trial is testing a drug called TAK-101, given through an IV, to help adults with celiac disease who still have symptoms despite following a gluten-free diet. The drug aims to reduce these symptoms by changing how the immune system reacts to gluten. TAK-101 is designed to induce gluten-specific tolerance by encapsulating gluten protein in negatively charged nanoparticles. Participants will receive the drug at different times and doses to see how well it works and how safe it is.
Trials With No Placebo
Behavioural Intervention
Timing of Gluten-free Oats Introduction for Celiac Disease
This trial is studying how early vs. late introduction of gluten-free oats can help improve gut symptoms, nutrition status, celiac activity and quality of life in celiac patients. Questionnaires, tests, physical exams and dietary analysis will be used.
Behavioral Intervention
Behavioral Intervention for Celiac Disease
This trial is testing a new way to help people with celiac disease who have to follow a strict gluten-free diet. The trial is testing a new intervention delivered through text messages and telehealth to help teens with celiac disease and their parents. The goal is to improve quality of life and management of the gluten-free diet by targeting self-efficacy, illness identity, and food-related activities.
Behavioural Intervention
Gluten-Free Diet Education for Celiac Disease
"This trial aims to show the benefits of a nutrition education program that focuses on natural gluten-free foods and limits processed gluten-free foods. The study will assess whether this education program can improve health outcomes."
Frequently Asked Questions
Introduction to celiac disease
What are the top hospitals conducting celiac disease research?
When it comes to advancing our understanding and treatment options for celiac disease, several hospitals across the United States are leading the way. One such institution is the Mayo Clinic in Rochester, which currently has four active clinical trials focused on this condition. With a total of 11 trials conducted over time since their first recorded trial in 1995, the Mayo Clinic is dedicated to finding innovative solutions for those affected by celiac disease. In Boston, both Massachusetts General Hospital and Beth Israel Deaconess Medical Center are making significant contributions as well. They each have three ongoing clinical trials related to celiac disease and have been conducting research since recording their first trial in 2009.
Further expanding the reach of these pioneering medical facilities, we look westward to Iowa City where researchers at the University of Iowa are actively involved in two clinical trials centered on celiac disease. Although they may be relatively new players in this field with only two recorded trials starting from 2018 onwards so far, their commitment is evident.
Notably smaller-scale yet equally important is Diablo Clinical Research located in Walnut Creek. This regional center focuses on cutting-edge investigations into various health conditions including celiac disease. Currently conducting two active clinical trials and having completed three previous studies since initiating its first trial also back in 2018; Diablo Clinical Research demonstrates that progress can occur at any scale.
These hospitals' dedication to studying celiac disease through rigorous clinical research not only provides hope for better diagnosis methods but also leads us closer towards effective treatments or even potential future cure for this autoimmune disorder affecting millions worldwide.
Which are the best cities for celiac disease clinical trials?
When it comes to celiac disease clinical trials, several cities are at the forefront of research. In Boston, Massachusetts, there are currently 10 active trials investigating treatments such as TAK-062, Gluten Powder, and Gluten Challenge. Rochester, Minnesota follows closely with 8 ongoing studies focused on therapies like TAK-101 and Cohort 2 in Part A. New york City also plays a significant role with 6 active trials exploring options like TAK-062 and PRV-015. These three cities offer individuals with celiac disease access to cutting-edge clinical trials that may lead to advancements in treatment options and improved quality of life.
Which are the top treatments for celiac disease being explored in clinical trials?
Exciting developments are underway in the realm of celiac disease treatment, with several innovative approaches being explored in recent clinical trials. A standout contender is Cohort 2 in Part A, a cutting-edge trial that aims to offer new possibilities for patients. Equally promising are DONQ52 and TAK-062, both undergoing active trials and showing great potential as future treatments. Additionally, gluten powder and Food for Thought have also emerged as contenders, demonstrating their efficacy through ongoing studies. These advancements hold promise for individuals living with celiac disease and bring hope for improved quality of life in the near future.
What are the most recent clinical trials for celiac disease?
Exciting developments are underway in the realm of celiac disease research, with recent clinical trials offering potential breakthroughs for patients. One such trial focuses on Ritlecitinib, a medication currently in Phase 2 of testing specifically designed to address celiac disease symptoms. Another promising study involves Cohort 2 in Part A, which combines Phase 1 and Phase 2 assessments to evaluate new treatment options. Additionally, DONQ52 and TAK-062 have shown promise as potential therapies through their respective Phase 1 and Phase 2 trials. Lastly, TAK-101 has also displayed encouraging results as it progresses through its own Phase 2 testing phase. These ongoing investigations provide hope for improved management and overall well-being for individuals living with celiac disease.
What celiac disease clinical trials were recently completed?
A recent clinical trial for celiac disease investigated the potential benefits of PTG-100 and was completed in February 2021. Led by Nielsen Fernandez-Becker, this study aimed to uncover new treatments and interventions for individuals living with celiac disease. The completion of this trial signifies an important step forward in understanding and addressing the challenges faced by those affected by this autoimmune disorder.