Childhood Leukemia Clinical Trials 2023

What are the top hospitals conducting childhood leukemia research?

When it comes to advancing the treatment options for childhood leukemia, several top hospitals are leading the charge. Washington University School of Medicine in Saint Louis stands out with seven ongoing clinical trials focused on childhood leukemia—a disease that affects young lives in distressing ways. With a remarkable track record of 65 completed trials since their first investigation in 1996, this institution is committed to improving the outcomes and quality of life for children battling this form of cancer.

Meanwhile, at City of Hope Comprehensive Cancer Center in Duarte, groundbreaking research continues with six active childhood leukemia trials. Since their initial study in 1999, they have amassed an impressive catalog of 48 completed trials dedicated to combating this devastating illness. Overcoming challenges head-on, these researchers strive to provide hope and healing for young patients and their families.

In Honolulu's Kapiolani Medical Center for Women and Children, another vital battleground against childhood leukemia emerges. This center currently hosts six active clinical trials aimed at unlocking new treatment possibilities. Despite its remote location amidst the breathtaking beauty of Hawaii's islands, Kapiolani Medical Center has contributed significantly to understanding pediatric oncology through its dedication to conducting studies on this condition since 2003.

Johns Hopkins University/Sidney Kimmel Cancer Center adds yet another renowned name in the fight against childhood leukemia. With six ongoing clinical trials targeting this disease and a noteworthy history encompassing 34 previously conducted studies dating back to their inaugural trial also starting from2003; they continue making strides towards better outcomes for affected children.

Lastly but certainly not least important is City of Hope Medical Center—their commitment evident through six current childhood leukemia trials while having previously carried out thirty-nine additional investigations—making significant contributions towards enhancing our understanding and ability to treat this complex condition since beginning such initiatives back as early as1997.

These prominent medical centers exemplify the tireless efforts being made by doctors and scientists worldwide who relentlessly work toward finding cures and improving the lives of children diagnosed with leukemia. Through their dedication, collaboration, and groundbreaking research, they are making significant strides in the fight against this devastating disease that affects so many young lives.

Which are the best cities for childhood leukemia clinical trials?

When it comes to childhood leukemia clinical trials, several cities have emerged as leaders in research and treatment. Honolulu, Hawaii boasts 40 active trials focusing on treatments like Vorinostat and rituximab, alongside laboratory biomarker analysis. Chicago, Illinois follows closely behind with 31 ongoing studies exploring the effectiveness of treatments such as Daunorubicin Hydrochloride and Ofatumumab. Houston, Texas also plays a significant role with 28 active trials investigating Treatment options including JCAR017 and Radiation Therapy. Los Angeles, California contributes to this vital research effort as well with 27 active trials examining Treatment methods involving Dexamethasone and Daunorubicin Hydrochloride. Additionally, Boston, Massachusetts is making strides in the field with 26 active trials testing Treatment approaches that incorporate Nivolumab and Rituximab. These cities collectively offer children diagnosed with leukemia access to cutting-edge clinical trials that hold promise for improved outcomes in their battle against this challenging disease.

Which are the top treatments for childhood leukemia being explored in clinical trials?

Clinical trials are actively exploring various treatments for childhood leukemia, offering hope to patients and families affected by this condition. Among the top contenders in these trials are:

• Rituximab: Currently involved in six active trials and with a solid track record of 49 all-time childhood leukemia studies since its introduction in 2002.
• Lenalidomide: Showcasing promise, it is being tested in three ongoing clinical trials specifically focusing on childhood leukemia. Since its first listing in 2010, it has been part of three all-time trials dedicated to fighting this disease.
• Ofatumumab: With involvement in three current clinical trials and having accumulated six previous childhood leukemia studies since 2011, Ofatumumab continues to be explored as a potential treatment option.
• Pharmacological Study: Gaining attention from researchers, this category encompasses diverse drug studies aimed at understanding how different pharmaceutical interventions can combat pediatric leukemia. It has an impressive tally of three ongoing clinical trials and boasts participation from 29 all-time research initiatives dating back to 2006. As these investigations progress, they offer valuable insights into new avenues for treating childhood leukemia.

The continuous pursuit of innovative therapies fuels optimism that breakthroughs will emerge soon—changing the landscape of care for children battling against this form of cancer.

What are the most recent clinical trials for childhood leukemia?

Recent clinical trials offer promising advancements in the treatment of childhood leukemia. One notable trial involves JCAR017, which has progressed to Phase 2 after demonstrating positive results in Phase 1. Additionally, Turalio and Autologous Lymphoma Immunoglobulin-derived scFv-chemokine DNA Vaccine have shown potential during their respective Phase 1 studies. Another study focuses on dose escalation of CD19 CAR T Cells for B-cell ALL, presenting a new avenue for targeted therapy. Lastly, Ibrutinib is being evaluated in Phase 3 trials as a potential treatment option for childhood leukemia. These ongoing trials provide hope and possibilities for improved outcomes among young patients battling this disease.

What childhood leukemia clinical trials were recently completed?

Recent advancements in childhood leukemia clinical trials showcase the tireless efforts of researchers to combat this devastating disease. Completed trials include Blinatumomab, sponsored by Amgen, in October 2020; Daunorubicin, sponsored by Children's Mercy Hospital Kansas City, in May 2020; and TC-110 T Cells, sponsored by TCR2 Therapeutics, in March 2020. These studies represent crucial steps forward as we strive to improve treatment outcomes for children fighting leukemia.