Popular Trials
Enema vs Oral Bowel Prep for Surgical Preparation
This trial compares two methods of bowel cleaning for patients having rectal surgery. One method uses Fleet enemas, which are inserted into the rectum, while the other uses Pico Salax, a drink. The goal is to determine which method provides better visibility and cleanliness for the surgery.
HIF-2alpha Inhibitor
Triple Drug Combo for Solid Cancers
This trial is testing a new treatment combining three drugs to help patients with difficult-to-treat cancers. The treatment aims to stop cancer growth, help the immune system fight the cancer, and cut off the blood supply to tumors.
Behavioural Intervention
Physical Activity Program for Colorectal Cancer
This trial aims to see if a physical activity program called PACE can help African American individuals with colorectal cancer. The study will look at how well the program is reaching people, how effective it is
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Trials for Colon Cancer Patients
AH-HA EHR Tool for Heart Health in Cancer Survivors
This trial is looking at the effects of a tool that uses electronic health records to help cancer survivors manage their cardiovascular health. The study will compare how well the tool works compared to usual care in terms of risk reduction and health promotion activities.
Small Molecule Inhibitor
RGX-202-01 Combination Therapy for Colorectal Cancer
This trial is testing a new drug, RGX-202-01, to see if it can shrink tumors in people with gastrointestinal cancer. The study will test different doses of the drug to see what is safe and effective. The study will also test the drug in combination with other drugs that are commonly used to treat gastrointestinal cancer.
Genetic Testing
Screening Method for Lynch Syndrome in Endometrial and Ovarian Cancer
This trial will test a new way of identifying women with Lynch Syndrome, a hereditary disease that can lead to cancer. If successful, it could improve screening and surgery options for women at risk.
Trials for Rectal Cancer Patients
AH-HA EHR Tool for Heart Health in Cancer Survivors
This trial is looking at the effects of a tool that uses electronic health records to help cancer survivors manage their cardiovascular health. The study will compare how well the tool works compared to usual care in terms of risk reduction and health promotion activities.
Small Molecule Inhibitor
RGX-202-01 Combination Therapy for Colorectal Cancer
This trial is testing a new drug, RGX-202-01, to see if it can shrink tumors in people with gastrointestinal cancer. The study will test different doses of the drug to see what is safe and effective. The study will also test the drug in combination with other drugs that are commonly used to treat gastrointestinal cancer.
Genetic Testing
Screening Method for Lynch Syndrome in Endometrial and Ovarian Cancer
This trial will test a new way of identifying women with Lynch Syndrome, a hereditary disease that can lead to cancer. If successful, it could improve screening and surgery options for women at risk.
Trials for Metastatic Patients
Small Molecule Inhibitor
RGX-202-01 Combination Therapy for Colorectal Cancer
This trial is testing a new drug, RGX-202-01, to see if it can shrink tumors in people with gastrointestinal cancer. The study will test different doses of the drug to see what is safe and effective. The study will also test the drug in combination with other drugs that are commonly used to treat gastrointestinal cancer.
PD-L1 Inhibitor
Durvalumab + Olaparib + Cediranib for Ovarian Cancer
This trial is testing the combination of Durvalumab, Olaparib, and Cediranib in adults with advanced or recurrent ovarian cancer to see how well they tolerate it and if it is effective in treating the cancer.
CAR T-cell Therapy
TC-510 Cell Therapy for Cancer
This trial tests TC-510, a therapy using a patient's own modified T cells to target and attack cancer cells. It is aimed at patients with cancers that are hard to treat with standard methods. The modified T cells are designed to recognize specific proteins on cancer cells and get an extra boost to kill them.
Trials for KRAS Positive Patients
Small Molecule Inhibitor
RGX-202-01 Combination Therapy for Colorectal Cancer
This trial is testing a new drug, RGX-202-01, to see if it can shrink tumors in people with gastrointestinal cancer. The study will test different doses of the drug to see what is safe and effective. The study will also test the drug in combination with other drugs that are commonly used to treat gastrointestinal cancer.
KRAS G12C Inhibitor
JDQ443 Combinations for Advanced Cancer
This trial tests JDQ443, a new drug, combined with other treatments for patients with advanced cancers having the KRAS G12C mutation. The drug aims to stop cancer growth by targeting a specific genetic fault.
Small Molecule Inhibitor
LY3537982 for Cancer
This trial is testing a new drug called LY3537982 in cancer patients with the KRAS G12C mutation. It targets this mutation to stop cancer cells from growing. The study includes patients who haven't responded to other treatments or cannot tolerate them. LY3537982 is a new drug targeting the KRAS G12C mutation, similar to previously approved drugs like sotorasib and adagrasib.
Monoclonal Antibodies
PF-07934040 + Other Anti-Cancer Therapies for Non-Small Cell Lung Cancer
This trial aims to test the safety and effectiveness of a new medication, PF-07934040, either alone or in combination with other anti-cancer treatments. They are looking for participants with advanced solid
Cancer Vaccine
Cancer Vaccine + Nivolumab + Ipilimumab for Pancreatic and Colorectal Cancer
This trial tests a special vaccine combined with immune-boosting drugs for patients with advanced pancreatic or colorectal cancer who have had extensive prior treatments. The goal is to train and enhance the immune system to better fight cancer. The vaccine has been used in previous studies to help the immune system recognize cancer cells in pancreatic cancer patients.
Trials for BRAF Positive Patients
PD-L1 Inhibitor
Durvalumab + Olaparib + Cediranib for Ovarian Cancer
This trial is testing the combination of Durvalumab, Olaparib, and Cediranib in adults with advanced or recurrent ovarian cancer to see how well they tolerate it and if it is effective in treating the cancer.
Monoclonal Antibodies
SGN-BB228 for Melanoma
This trial is testing a new drug called SGN-BB228 to see if it can help treat difficult-to-treat cancers like melanoma and other solid tumors. The study will determine the safest amount of the drug to give and check if it works in shrinking or eliminating these tumors. The goal is to find a new treatment option for patients whose cancers are not responding to current therapies.
Kinase Inhibitor
Triple Therapy for Advanced Solid Cancers
This trial is testing the side effects and best dose of vemurafenib when given with cetuximab and irinotecan hydrochloride to treat patients with solid tumors. Vemurafenib and irinotecan hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Cetuximab may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Monoclonal Antibodies
Encorafenib + Cetuximab + Nivolumab for Colorectal Cancer
This trial is testing a combination of drugs to treat patients with colorectal cancer that has spread and cannot be removed by surgery. The drugs work by blocking enzymes needed for cell growth and by helping the body's immune system attack the cancer.
Phase 3 Trials
Checkpoint Inhibitor
Nivolumab-relatlimab Combo for Colorectal Cancer
This trial is testing a combination of two drugs, relatlimab and nivolumab, for patients with a certain type of colorectal cancer who haven't responded to other treatments. The drugs help the immune system attack the cancer.
Small Molecule Kinase Inhibitor
Tucatinib + Trastuzumab + Chemotherapy for Colorectal Cancer
This trial is testing to see if tucatinib in combination with other drugs is more effective than standard of care drugs at treating participants with HER2 positive colorectal cancer.
Trials With No Placebo
AH-HA EHR Tool for Heart Health in Cancer Survivors
This trial is looking at the effects of a tool that uses electronic health records to help cancer survivors manage their cardiovascular health. The study will compare how well the tool works compared to usual care in terms of risk reduction and health promotion activities.
Small Molecule Inhibitor
RGX-202-01 Combination Therapy for Colorectal Cancer
This trial is testing a new drug, RGX-202-01, to see if it can shrink tumors in people with gastrointestinal cancer. The study will test different doses of the drug to see what is safe and effective. The study will also test the drug in combination with other drugs that are commonly used to treat gastrointestinal cancer.
Genetic Testing
Screening Method for Lynch Syndrome in Endometrial and Ovarian Cancer
This trial will test a new way of identifying women with Lynch Syndrome, a hereditary disease that can lead to cancer. If successful, it could improve screening and surgery options for women at risk.
View More Related Trials
Frequently Asked Questions
Introduction to colorectal cancer
What are the top hospitals conducting colorectal cancer research?
Colorectal cancer, a formidable adversary in the world of oncology, is being met head-on by some of the top hospitals in the United States. Leading the charge is Memorial Sloan Kettering Cancer Center in New york City, renowned for its cutting-edge research and patient care. With 12 active colorectal cancer trials and an impressive history of 70 trials dedicated to this disease, their commitment spans over three decades since recording their first trial back in 1989.
Heading south to Houston, we find M D Anderson Cancer Center making significant strides against colorectal cancer with nine ongoing clinical trials and a commendable track record of 49 completed studies. This prestigious institution recorded its first colorectal cancer trial in 2001, showcasing their dedication to combating this condition.
Back on the East Coast lies Massachusetts General Hospital in Boston—a powerhouse when it comes to medical advancements. They are currently conducting eight active colorectal cancer trials while having accomplished an extraordinary total of 71 previous investigations since initiating their inaugural trial also in 2001.
In Atlanta's Emory University Hospital/Winship Cancer Institute, researchers are dedicating themselves to pushing boundaries with seven ongoing clinical trials focused on colorectal cancer. Although they may have fewer all-time trials compared to others on this list (15), they have made remarkable progress since recording their first colorectal cancer trial as recently as 2012.
Last but certainly not least is Duke University Medical Center located within Durham—their contributions should not be underestimated. Currently engaged in six active clinical trials for colorectal cancer treatment options and having completed thirty-three prior investigations dating back from their initial pioneering study recorded backin2003;their work plays a vital role alongside other leading institutions across the nation.
These top-tier hospitals continue to wage war against colorectal cancers through rigorous research efforts and innovative treatments that bring hope to patients battling this disease worldwide. Their collective determination guides us toward brighter futures where improved outcomes become a reality for all those affected by colorectal cancer.
Which are the best cities for colorectal cancer clinical trials?
When it comes to colorectal cancer clinical trials, several cities have emerged as leading hubs for research. Los Angeles, California has 41 active trials focusing on treatment options like Eflornithine plus sulindac and Nivolumab. Boston, Massachusetts follows closely behind with 34 ongoing studies investigating treatments such as Radiation Therapy and JDQ443+trametinib. New york, New York also plays a significant role in colorectal cancer research with 30 active trials exploring treatment options like Pembrolizumab and pralsetinib (BLU-667). Houston, Texas and Atlanta, Georgia offer their own contributions to the field with 27 and 21 active trials respectively. These cities provide individuals facing colorectal cancer access to cutting-edge clinical trials that may revolutionize treatment approaches and improve outcomes.
Which are the top treatments for colorectal cancer being explored in clinical trials?
Colorectal cancer research is making significant strides, with a focus on several promising treatments currently being explored in clinical trials. Leading the pack is pembrolizumab, which has garnered attention in four active trials and 56 all-time colorectal cancer studies since its first listing in 2013. Another contender worth noting is nivolumab, involved in three ongoing trials and boasting an impressive track record of 39 all-time colorectal cancer studies since its introduction in 2014. Additionally, capecitabine deserves recognition for its two active trials and participation in a remarkable 111 all-time colorectal cancer studies since it was listed back in 2001. The progress made through these clinical trials offers renewed hope to patients battling this challenging disease each day.
What are the most recent clinical trials for colorectal cancer?
Exciting advancements are being made in the field of colorectal cancer research, with several recent clinical trials offering hope for improved treatment options. A2530 is currently undergoing Phase 1 and Phase 2 trials, demonstrating its potential to tackle this form of cancer. NUFIRI-bev on a Q1W NUC-3373 schedule is also being investigated in Phase 2 studies as a potential therapy option. Another promising trial involves botensilimab and balstilimab (bot/bal), which has entered Phase 2 testing for colorectal cancer patients. Additionally, SGN-BB228 showcases promise based on its ongoing Phase 1 trial results. Finally, tucatinib's efficacy as a treatment for colorectal cancer is under evaluation through its participation in a large-scale Phase 3 study initiated last year. These collective efforts signify significant progress towards improving outcomes for individuals affected by colorectal cancer.
What colorectal cancer clinical trials were recently completed?
Several notable clinical trials for colorectal cancer have recently concluded, demonstrating significant progress in the field. In January 2022, a trial by Mayo Clinic investigated the potential of Colorectal Cancer Peptide Vaccine PolyPEPI1018. Following closely behind is a trial conducted by Janssen Research & Development and completed in November 2021, which examined JNJ-64251330 therapy. Notably, Apros Therapeutics' APR003 study reached completion in January 2021. These recent advancements highlight the ongoing efforts to enhance treatment options for patients affected by colorectal cancer.