Amino Acid
Levocarnitine for Dry Eye in Sjogren's Syndrome
This trial tests levocarnitine, a supplement that helps transport carnitine into cells, in adults with Sjogren's syndrome who have dry eyes. Sjogren's syndrome causes dryness in the eyes and mouth. Levocarnitine may help by increasing carnitine levels in tears, potentially reducing eye dryness and improving comfort. Levocarnitine is a molecule required in mammalian energy metabolism, facilitating the transport of long-chain fatty acids across the mitochondrial membrane for energy production.
Biological
rhNGF Eye Drops for Dry Eye Syndrome
This trial aims to test the safety and effectiveness of two different strengths of a new eye drop solution compared to a placebo, in treating dry eye disease. Participants will use the eye drops three times a day
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Trials With No Placebo
Device
LipiFlow +1 More for Meibomian Gland Dysfunction
In this study, the TearCare System will be compared with the LipiFlow Thermal Pulsation System in patients with dry eye disease. The objective is to demonstrate that the TearCare System is safe and effective in relieving the signs and symptoms of dry eye disease. NOTE: All sites have been selected for this study. We are not seeking additional sites at this time.
Procedure
TearCare for Dry Eye Syndrome
This study is being conducted to evaluate the short-term (1 month) safety and effectiveness of a single TearCare procedure to treat adult patients with dry eye disease. NOTE: All sites have been selected for this study.
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Frequently Asked Questions
Introduction to dry eye
What are the top hospitals conducting dry eye research?
When it comes to cutting-edge research and clinical trials aimed at addressing the discomfort of dry eye, several leading hospitals are making significant strides. In Colorado Springs, the Vision Institute is actively involved in five ongoing dry eye trials and has a total track record of ten studies dedicated to this condition. Their first foray into dry eye research began in 2014, marking their commitment to finding innovative solutions. Meanwhile, the Eye Research Foundation in Newport Beach has four active dry eye trials underway and an impressive history of twenty-five previously conducted studies since embarking on its pioneering journey in 2014.
As we move to St. Louis, Ophthalmology Associates stands out with four currently active clinical trials focused on alleviating dry eye symptoms while having accomplished eighteen significant investigations since initiating their inaugural trial back in 2009. The dedication shown by these institutions towards understanding and treating this prevalent condition cannot be underestimated.
Additionally contributing to this important field is Oculus Research located in Garner—a relatively new entrant—currently conducting three active dry-eye trials; although they have only initiated four inquiries thus far (beginning as recently as2022), their impact holds enormous potential for future advancements within the realm of treating dry eyes effectively.
Last but certainly not least among our top hospitals is West Bay Eye Associates situated in Warwick which also boasts three current clinical investigations targeting various aspects related with relieving symptoms caused by chronic tear dysfunction; yet like Oculus Research , West Bay's findings continue shaping up through carrying out preliminary tests from merely two years ago(2019).
These exceptional hospitals collectively demonstrate an unwavering commitment to improving the lives of those affected by debilitating cases of chronic tears insufficiency.Through tireless efforts such as theirs,the horizon appears brighter for countless individuals seeking relief from chronically irritated or inflamed eyes that affect daily life comforts.These medical pioneers remind us how curiosity-driven exploration combined with advanced techniques can result into improved treatment options catering better quality-of-life options to dry eye sufferers worldwide.
Which are the best cities for dry eye clinical trials?
When it comes to dry eye clinical trials, several cities stand out as prime locations for cutting-edge research. Newport Beach, California leads the pack with 14 active trials focusing on treatments like Tivanisiran sodium ophthalmic solution, 5% Tavilermide ophthalmic solution, and K-161. Memphis, Tennessee follows closely behind with 9 ongoing studies examining interventions such as 5% Tavilermide ophthalmic solution and OTX-DED 0.3mg. Lastly, Kansas City in Missouri boasts 7 active trials exploring options like 5% Tavilermide ophthalmic solution and Tivanisiran sodium ophthalmic solution. These cities offer individuals suffering from dry eye access to advanced clinical trials that harbor potential breakthroughs in treatment strategies and improved quality of life.
Which are the top treatments for dry eye being explored in clinical trials?
Exciting advancements are underway in the search for effective treatments for dry eye. Among the top contenders being explored in clinical trials are:
- Oxervate: Currently engaged in two active trials and has a total of two all-time dry eye trials since its debut in 2022.
- Tivanisiran sodium ophthalmic solution: Making waves with its participation in two ongoing trials, it has accumulated a commendable count of two all-time dry eye studies since hitting the scene in 2021.
- TearCare: Still proving its mettle, this treatment is currently involved in two active trials and has been part of five all-time dry eye studies since first being listed back in 2016.
- IC265 Ophthalmic Solution 1%: A relative newcomer to the field, this solution is currently enlisted in one active trial while boasting one all-time dry eye study after making its debut just last year.
These promising options provide hope for individuals suffering from dry eyes as researchers continue their dedicated efforts to alleviate symptoms and enhance quality of life.
What are the most recent clinical trials for dry eye?
Exciting advancements are being made in the field of dry eye treatment, with a number of recent clinical trials offering hope to those affected by this condition. One promising trial focuses on the use of Omega-3 supplements, which have shown potential in alleviating dry eye symptoms. Additionally, a Phase 3 study has evaluated the effectiveness of 5% Tavilermide ophthalmic solution for managing dry eye. Another trial investigated OTX-DED 0.3mg as a potential treatment option during its Phase 2 stage. In addition, Low Dose OK-101 and TL-925 Arm both demonstrated promise for addressing dry eye symptoms during their respective Phase 2 studies. These developments bring us closer to improved therapies and relief for individuals experiencing the effects of dry eye.
What dry eye clinical trials were recently completed?
Several recent clinical trials have been completed, demonstrating the ongoing efforts to find effective treatments for dry eye. In September 2022, the State University of New york College of Optometry concluded a trial investigating Lifitegrast 5% Ophthalmic Solution. Similarly, in July 2022, Seikagaku Corporation completed their study on SI-614. Allgenesis Biotherapeutics Inc.'s trial for AG-80308 wrapped up in June 2022. These and other recently finished trials signify the commitment to addressing dry eye and provide hope for improved therapies in the future.