Alkylating agents
PLDR + Chemotherapy for Lung Cancer
This trial is a Phase I study testing whether Pulsed Low Dose Radiation (PLDR) can significantly decrease the rate of severe acute esophagitis in patients receiving concurrent Chemo-radiation therapy (CRT) for non-small cell lung cancer or esophageal cancer while maintaining similar efficacy.
PD-1 Inhibitor
Immunotherapy + Chemoradiation for Gastroesophageal Cancer
This trial will test if giving patients anti-PD-1 or anti-PD1/anti LAG-3 before surgery, along with chemoradiation, is safe and improves survival in patients with resectable distal esophageal/gastroesophageal junction cancer.
Checkpoint Inhibitor
Pembrolizumab + Chemotherapy for Esophageal Cancer
This trial is testing if adding pembrolizumab to standard treatments can help patients with advanced esophageal cancer. Pembrolizumab boosts the immune system to better fight cancer. The goal is to see if this combination improves patient outcomes. Pembrolizumab has been used in various cancers, including melanoma, lung cancer, and head and neck cancer, showing durable responses and significant advancements in treatment options.
Popular Filters
Trials for Adenocarcinoma Patients
Monoclonal Antibodies
Sacituzumab + Pembrolizumab + Chemotherapy for Esophageal Cancer
This trial is testing a new combination of drugs for the treatment of advanced stomach, esophageal, or gastroesophageal junction cancer. The trial has two phases to evaluate the safety and effectiveness of
Monoclonal Antibodies
Combination Therapies for Esophageal Cancer
This trial is testing two different combinations of drugs to see which one is safer and more effective for treating advanced stomach, esophageal, or gastroesophageal junction cancer in participants who have not responded
ActivSight Imaging for Esophageal Surgery
This trial uses a device that creates a visual representation of blood flow and tissue perfusion during laparoscopic surgery. It will compare accuracy of the device to naked eye inspection and other imaging techniques.
HIF-2alpha Inhibitor
Triple Drug Combo for Solid Cancers
This trial is testing a new treatment combining three drugs to help patients with difficult-to-treat cancers. The treatment aims to stop cancer growth, help the immune system fight the cancer, and cut off the blood supply to tumors.
Trials for Squamous Cell Carcinoma Patients
Monoclonal Antibodies
Sacituzumab + Pembrolizumab + Chemotherapy for Esophageal Cancer
This trial is testing a new combination of drugs for the treatment of advanced stomach, esophageal, or gastroesophageal junction cancer. The trial has two phases to evaluate the safety and effectiveness of
Monoclonal Antibodies
Combination Therapies for Esophageal Cancer
This trial is testing two different combinations of drugs to see which one is safer and more effective for treating advanced stomach, esophageal, or gastroesophageal junction cancer in participants who have not responded
ActivSight Imaging for Esophageal Surgery
This trial uses a device that creates a visual representation of blood flow and tissue perfusion during laparoscopic surgery. It will compare accuracy of the device to naked eye inspection and other imaging techniques.
Monoclonal Antibodies
MK-7684A for Advanced Cancers
This trial is testing a new treatment that combines two medications to see if it works better than the current treatment for serious cancers, particularly cervical cancer. One of the medications has shown promising results in treating various cancers, including cervical cancer. The goal is to find out if this combination can improve patient outcomes by helping the immune system fight cancer more effectively.
HIF-2alpha Inhibitor
Triple Drug Combo for Solid Cancers
This trial is testing a new treatment combining three drugs to help patients with difficult-to-treat cancers. The treatment aims to stop cancer growth, help the immune system fight the cancer, and cut off the blood supply to tumors.
Trials for Metastatic Patients
Monoclonal Antibodies
Sacituzumab + Pembrolizumab + Chemotherapy for Esophageal Cancer
This trial is testing a new combination of drugs for the treatment of advanced stomach, esophageal, or gastroesophageal junction cancer. The trial has two phases to evaluate the safety and effectiveness of
Monoclonal Antibodies
Combination Therapies for Esophageal Cancer
This trial is testing two different combinations of drugs to see which one is safer and more effective for treating advanced stomach, esophageal, or gastroesophageal junction cancer in participants who have not responded
Monoclonal Antibodies
MK-7684A for Advanced Cancers
This trial is testing a new treatment that combines two medications to see if it works better than the current treatment for serious cancers, particularly cervical cancer. One of the medications has shown promising results in treating various cancers, including cervical cancer. The goal is to find out if this combination can improve patient outcomes by helping the immune system fight cancer more effectively.
HIF-2alpha Inhibitor
Triple Drug Combo for Solid Cancers
This trial is testing a new treatment combining three drugs to help patients with difficult-to-treat cancers. The treatment aims to stop cancer growth, help the immune system fight the cancer, and cut off the blood supply to tumors.
PARP Inhibitor
Veliparib + Chemotherapy for Advanced Cancer
This trial is studying the side effects and best dose of veliparib when given with paclitaxel and carboplatin to treat patients with solid tumors that have spread or cannot be removed by surgery and have liver or kidney dysfunction.
Monoclonal Antibodies
Paclitaxel +/− Cixutumumab for Esophageal Cancer
This trial is testing how well paclitaxel (a chemotherapy drug) works with or without cixutumumab (a protein-blocking drug) to treat patients with esophageal or gastroesophageal junction cancer that has spread to other parts of the body.
Trials for HER2 Positive Patients
PARP Inhibitor
Berzosertib + Irinotecan for Gastric Cancer
This trial tests a combination of berzosertib and irinotecan in patients with advanced gastric or gastroesophageal junction cancer. Berzosertib blocks enzymes needed for cancer growth, and irinotecan kills or stops the spread of cancer cells. Irinotecan has been used in various combinations for treating advanced gastric and gastroesophageal cancers, showing some efficacy but not proving superior to other treatments. The goal is to find a more effective treatment for these difficult-to-treat cancers.
Monoclonal Antibodies
Pembrolizumab + Trastuzumab + Chemotherapy for Gastric Cancer
This trial will compare the efficacy of two different treatments for HER2-positive gastric cancer. The first treatment is pembrolizumab in combination with standard chemotherapy, and the second is trastuzumab in combination with standard chemotherapy. The hypothesis of the study is that pembrolizumab is superior to trastuzumab in terms of progression free survival and overall survival.
Enzyme Inhibitor
Ceralasertib + Trastuzumab Deruxtecan for Solid Tumors
This trial will find the best dose and safety of ceralasertib when given with trastuzumab deruxtecan to treat patients with solid tumors that have a change in the HER2 gene or protein.
Trials for PD-L1 Positive Patients
Checkpoint Inhibitor
Sonidegib + Pembrolizumab for Advanced Cancers
This trial tests the best dose of sonidegib combined with pembrolizumab for treating advanced solid tumors. Sonidegib blocks enzymes needed for tumor growth, while pembrolizumab helps the immune system attack cancer. The study focuses on patients with advanced cancers that have spread, aiming to find a more effective treatment than standard options.
Chemotherapy
Immunotherapy Combinations for Esophageal Cancer
This trial tests a combination of chemotherapy and immunotherapy in patients with advanced gastric and esophageal cancers. It aims to see if this combination is safe and effective, especially for those who haven't responded to other treatments or haven't been treated before. Combination therapies involving chemotherapy and immunotherapy have shown promising results in initial clinical trials for cancer treatment.
Phase 3 Trials
Monoclonal Antibodies
Pembrolizumab + Trastuzumab + Chemotherapy for Gastric Cancer
This trial will compare the efficacy of two different treatments for HER2-positive gastric cancer. The first treatment is pembrolizumab in combination with standard chemotherapy, and the second is trastuzumab in combination with standard chemotherapy. The hypothesis of the study is that pembrolizumab is superior to trastuzumab in terms of progression free survival and overall survival.
Alkylating agents
Chemotherapy + Radiotherapy for Esophageal and Gastric Cancer
This trial is studying how well adding radiotherapy to the usual chemotherapy treatment works compared to the usual treatment alone in treating patients with esophageal and gastric cancer.
Monoclonal Antibodies
Pembrolizumab + Lenvatinib + Chemo for Esophageal Cancer
This trial tests a new combination of drugs and chemotherapy for advanced esophageal cancer. It targets patients whose cancer has spread and who need effective first-line treatment. The treatment works by enhancing the immune system, blocking cancer growth, and killing cancer cells.
Monoclonal Antibodies
Bemarituzumab + Chemotherapy for Stomach Cancer
This trial is testing whether adding bemarituzumab to standard chemotherapy helps patients live longer. It targets patients whose tumors have a specific marker (FGFR2b). The treatment works by blocking a protein that helps cancer cells grow.
Trials With No Placebo
Monoclonal Antibodies
Sacituzumab + Pembrolizumab + Chemotherapy for Esophageal Cancer
This trial is testing a new combination of drugs for the treatment of advanced stomach, esophageal, or gastroesophageal junction cancer. The trial has two phases to evaluate the safety and effectiveness of
Monoclonal Antibodies
Combination Therapies for Esophageal Cancer
This trial is testing two different combinations of drugs to see which one is safer and more effective for treating advanced stomach, esophageal, or gastroesophageal junction cancer in participants who have not responded
ActivSight Imaging for Esophageal Surgery
This trial uses a device that creates a visual representation of blood flow and tissue perfusion during laparoscopic surgery. It will compare accuracy of the device to naked eye inspection and other imaging techniques.
Monoclonal Antibodies
MK-7684A for Advanced Cancers
This trial is testing a new treatment that combines two medications to see if it works better than the current treatment for serious cancers, particularly cervical cancer. One of the medications has shown promising results in treating various cancers, including cervical cancer. The goal is to find out if this combination can improve patient outcomes by helping the immune system fight cancer more effectively.
HIF-2alpha Inhibitor
Triple Drug Combo for Solid Cancers
This trial is testing a new treatment combining three drugs to help patients with difficult-to-treat cancers. The treatment aims to stop cancer growth, help the immune system fight the cancer, and cut off the blood supply to tumors.
View More Related Trials
Frequently Asked Questions
Introduction to esophageal cancer
What are the top hospitals conducting esophageal cancer research?
When it comes to advancing the treatment options for esophageal cancer, several top hospitals are leading the way. In Houston, M D Anderson Cancer Center is at the forefront with an impressive 13 ongoing clinical trials focused on this challenging condition. Having initiated their first recorded trial in 2003, they have since conducted a total of 24 esophageal cancer trials, showcasing their commitment to finding better solutions for patients. Meanwhile, in Saint Louis, Washington University School of Medicine has been making significant contributions as well. With seven active esophageal cancer trials and a history of 18 completed studies dating back to their inaugural trial in 2005.
In Tampa's Moffitt Cancer Center also joins these pioneering institutions with six ongoing esophageal cancer clinical trials. Although having conducted only seven previous investigations since recording its first trial back in 2002; Moffitt's dedication is evident through their research efforts towards improving outcomes for patients battling this disease.
Further adding itself to this list is New york City's renowned Memorial Sloan Kettering Cancer Center where they currently have five active clinical trials dedicated solely to esophageal cancer after successfully completing twenty-three such investigations following their initiation into conducting them from fifteen years ago during its first recorded study held on same grounds starting from year2002
Finally the West coast enters with University of California Davis Comprehensive Cancer center joining the league by presenting five current tests being carried out pertaining exclusively towards Esophagal cases alongside completion of prior eight other related investigative projects; marked as relatively new player considering that theirs began approximately ten years ago since welcoming Esophagal subject matters within hospital compound.
These hospitals represent beacons of hope and progress in the field of esophageal cancer research. By actively pursuing innovative approaches and conducting rigorous clinical trials specific to this disease, they inspire confidence and provide opportunities for improved outcomes and quality of life for individuals affected by Esophagal malignancies
Which are the best cities for esophageal cancer clinical trials?
When it comes to esophageal cancer clinical trials, several cities stand out as leaders in research and development. New york City leads the way with 27 active trials investigating treatments like BMS-986340, Lenvatinib & Pembrolizumab, and other innovative approaches. Following closely behind is Houston, Texas, with 25 ongoing studies focusing on various treatment options such as Proton Beam Radiation Therapy and Nivolumab. Los Angeles, California also emerges as a prominent city for esophageal cancer clinical trials, with 23 active studies exploring treatments like DKN-01 and Pembrolizumab. These cities offer individuals battling esophageal cancer access to cutting-edge trials that hold promise for improved outcomes and new therapeutic options.
Which are the top treatments for esophageal cancer being explored in clinical trials?
The field of esophageal cancer research is abuzz with several promising treatments currently being explored in clinical trials. Among the top contenders are:
- Pharmacological Study, which has shown potential through three active trials and five all-time esophageal cancer trials since its first listing in 2010.
- Nivolumab, a breakthrough immunotherapy drug that is making waves with three ongoing trials and an impressive track record of 22 all-time esophageal cancer trials since its introduction in 2015.
- Pembrolizumab, another immunotherapy treatment that is showing promise in the fight against esophageal cancer, with three active trials and 31 all-time clinical studies conducted since it was listed as a treatment option back in 2014.
- Itraconazole, a newer player on the scene but already gaining attention for its potential benefits. It too boasts three active clinical trials dedicated to exploring its efficacy for treating esophageal cancer since it was first listed as a therapeutic option in 2016.
These exciting advancements offer hope for improved outcomes and better quality of life for individuals battling this challenging disease.
What are the most recent clinical trials for esophageal cancer?
Recent clinical trials have brought forth promising advancements in the field of esophageal cancer treatment. CA-4948, a Phase 1 trial initiated on June 2, 2023, has shown potential for esophageal cancer patients. Additionally, Enterotracker and Nutritional Supplementation are being explored through Phase 1 and Phase 3 trials respectively to determine their efficacy in managing this disease. Furthermore, the combination chemotherapy regime FOLFIRI (sFOLFOXIRI) is being investigated in a Phase 2 study that began on July 13, 2022. Another notable trial is examining the use of Neratinib plus TDxD for esophageal cancer treatment as part of a Phase 1 trial which commenced on June 24, 2022. These studies hold promise for improving outcomes and providing new therapeutic options for individuals affected by esophageal cancer.
What esophageal cancer clinical trials were recently completed?
Recently, several clinical trials investigating potential treatments for esophageal cancer have concluded, offering hope to patients and advancing our understanding of this challenging disease. In January 2021, EMD Serono Research & Development Institute completed a trial focusing on M1231. Furthermore, trials sponsored by City of Hope Medical Center (April 2019), Sidney Kimmel Cancer Center at Thomas Jefferson University (September 2018), M.D. Anderson Cancer Center (February 2018), Duke University (January 2018), Merck Sharp & Dohme LLC (July 2017), and Dana-Farber Cancer Institute (January 2017) have also reached completion in recent years. These accomplishments reflect the ongoing commitment of researchers to explore innovative therapeutic avenues for esophageal cancer treatment.