Trials in Boston, Massachusetts
Here are the top 10 medical studies for lung cancer in Boston, Massachusetts
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Phase 3 Trials
Platinum-based Chemotherapy
Pembrolizumab + Chemoradiation +/- Olaparib for Stage III Lung Cancer
Recruiting1 awardPhase 3
Boston, Massachusetts
This trial will compare the efficacy of three different treatments for unresectable, locally advanced NSCLC. Arm 1 will receive pembrolizumab concurrently with chemoradiation, followed by pembrolizumab with olaparib placebo. Arm 2 will receive the same treatment as Arm 1, but will take olaparib instead of the placebo. Arm 3 will receive concurrent chemoradiation therapy followed by durvalumab. The primary hypothesis is that pembrolizumab with concurrent chemoradiation and olaparib is superior to durvalumab with respect to PFS and OS.
Chemotherapy
Adagrasib + Pembrolizumab for Lung Cancer
Recruiting1 awardPhase 2 & 3
Boston, Massachusetts
This trial tests two drugs, MRTX849 and pembrolizumab, in patients with advanced lung cancer who have a specific genetic mutation. MRTX849 targets the mutation to stop cancer growth, while pembrolizumab boosts the immune system to fight the cancer. The study aims to see how well these treatments work alone and together.
Radiation Therapy
Stereotactic Radiosurgery vs Whole-Brain Radiotherapy for Brain Metastasis from Lung Cancer
Recruiting2 awardsPhase 3
Boston, Massachusetts
This trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus for the treatment of small cell lung cancer that has spread to the brain.
Chemotherapy + Osimertinib for Non-Small Cell Lung Cancer
Recruiting1 awardPhase 3
Boston, Massachusetts
This trial tests a combination of chemotherapy and osimertinib in patients with advanced lung cancer that has spread outside the brain after earlier treatment. Osimertinib blocks a protein that helps cancer grow, and chemotherapy kills cancer cells. Osimertinib has shown improvements in progression-free survival over earlier treatments and is preferred for initial treatment of EGFR-mutant NSCLC.
Trials With No Placebo
GMCI + Immunotherapy for Lung Cancer
Recruiting1 awardPhase 2
Farmington, Connecticut
This trial is testing whether adding a new cancer treatment, Gene Mediated Cytotoxic Immunotherapy (GMCIâ„¢), to the standard of care improves response rates and clinical outcomes for patients with stage III/IV non-small cell lung cancer who have stopped responding to their first line of immune checkpoint inhibitor (ICI) treatment.
Monoclonal Antibodies
HPN328 + Atezolizumab for Small Cell Lung Cancer
Recruiting1 awardPhase 1 & 2
Boston, Massachusetts
This trial is testing a new drug, HPN328, alone and with another drug, Atezolizumab, in patients with advanced cancers that have a specific protein called DLL3. The goal is to see if these treatments can help the immune system find and destroy cancer cells. This is aimed at patients whose cancers are hard to treat with standard therapies.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.