Alkylating agents
Oral Irinotecan + Temozolomide for Pediatric Solid Cancers
Recruiting1 awardPhase 1
Cincinnati, Ohio
This trial is testing a new flavored oral medicine called Orotecan® combined with temozolomide to treat children and young adults with recurring solid tumors. The treatment works by damaging the DNA of cancer cells to stop their growth. Temozolomide has been used in various trials for treating different types of tumors, including gliomas and medulloblastomas.
Protein Kinase Inhibitor
CX-4945 for Medulloblastoma
Recruiting1 awardPhase 1 & 2
Los Angeles, California
This trial tests an oral drug called CX-4945 for patients with a recurring type of brain tumor. The drug aims to block a protein that helps cancer cells grow. The study will determine the best dose and check for side effects. CX-4945 has shown promising results in other types of cancer and may be developed as a new therapy.
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Trials for Diffuse Intrinsic Pontine Glioma Patients
Chemotherapy
High-Dose Consolidation Chemotherapy for Medulloblastoma
Recruiting3 awardsPhase 4
Birmingham, Alabama
This trial is testing whether giving a higher dose of Consolidation (a cancer treatment) to high-risk patients with medulloblastoma will improve event-free survival (EFS) and overall survival (OS) without adding significant short-term or long-term side effects.
Topoisomerase II inhibitors
Chemotherapy + Stem Cell Transplant for Brain Cancer
Recruiting2 awardsPhase 3
Birmingham, Alabama
This trial is studying two different chemotherapy combinations to compare how well they work in treating young patients with newly diagnosed supratentorial primitive neuroectodermal tumors or high-risk medulloblastoma.
Trials for Brain Cancer Patients
Chemotherapy
High-Dose Consolidation Chemotherapy for Medulloblastoma
Recruiting3 awardsPhase 4
Birmingham, Alabama
This trial is testing whether giving a higher dose of Consolidation (a cancer treatment) to high-risk patients with medulloblastoma will improve event-free survival (EFS) and overall survival (OS) without adding significant short-term or long-term side effects.
Topoisomerase II inhibitors
Chemotherapy + Stem Cell Transplant for Brain Cancer
Recruiting2 awardsPhase 3
Birmingham, Alabama
This trial is studying two different chemotherapy combinations to compare how well they work in treating young patients with newly diagnosed supratentorial primitive neuroectodermal tumors or high-risk medulloblastoma.
Trials for Metastatic Patients
Chemotherapy
High-Dose Consolidation Chemotherapy for Medulloblastoma
Recruiting3 awardsPhase 4
Birmingham, Alabama
This trial is testing whether giving a higher dose of Consolidation (a cancer treatment) to high-risk patients with medulloblastoma will improve event-free survival (EFS) and overall survival (OS) without adding significant short-term or long-term side effects.
Topoisomerase II inhibitors
Chemotherapy + Stem Cell Transplant for Brain Cancer
Recruiting2 awardsPhase 3
Birmingham, Alabama
This trial is studying two different chemotherapy combinations to compare how well they work in treating young patients with newly diagnosed supratentorial primitive neuroectodermal tumors or high-risk medulloblastoma.
Cancer Vaccine
SurVaxM Vaccine for Brain Cancer
Recruiting1 awardPhase 1
Buffalo, New York
This trial tests the SurVaxM vaccine, which helps the immune system target and destroy cancer cells, in children and young adults with certain difficult-to-treat brain cancers. The vaccine works by teaching the immune system to recognize a protein found in cancer cells. Additional substances are used to make the immune response stronger.
Trials With No Placebo
Checkpoint Inhibitor
Nivolumab for Brain Cancer
Recruiting1 awardPhase 2
La Jolla, California
This trial will test whether the immunotherapy drug nivolumab is an effective treatment for people with rare CNS tumors by measuring the shrinkage of tumors or the amount of time it takes for the tumors to grow or spread.
Chemotherapy
High-Dose Consolidation Chemotherapy for Medulloblastoma
Recruiting3 awardsPhase 4
Birmingham, Alabama
This trial is testing whether giving a higher dose of Consolidation (a cancer treatment) to high-risk patients with medulloblastoma will improve event-free survival (EFS) and overall survival (OS) without adding significant short-term or long-term side effects.
Platinum-based Chemotherapy
Risk-Directed Therapy for Medulloblastoma
Recruiting1 awardPhase 2
Palo Alto, California
This trial will use a new way to treat medulloblastoma, which is a cancer of the brain. The treatment will be based on the amount of leftover disease present after surgery, as well as the type of cancer cells. This will help to determine the best way to treat the cancer and improve the outcome for patients.
Cancer Vaccine
Vaccine Immunotherapy for Pediatric Brain Cancer
Recruiting1 awardPhase 2
Los Angeles, California
This trial uses special immune cells and vaccines made from the patient's tumor to treat children with recurring brain tumors. The goal is to help their immune system recognize and destroy cancer cells, offering a new option for those who do not respond well to traditional treatments.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.