KL1333 for Mitochondrial Disease
Recruiting0 awardsPhase 2
Houston, Texas
This trial is testing KL1333, a new medicine, to see if it can help people with mitochondrial disease feel less tired and improve their physical abilities. The study targets people with primary mitochondrial disease because they often suffer from severe fatigue. KL1333 works by boosting energy production in cells.
MT1621 for TK2 Deficiency
Recruiting1 awardPhase 2
New York, New York
This trial is testing a new drug, MT1621, for safety and efficacy in people with a deficiency in the TK2 protein. The trial will compare measurements taken before treatment with dC/dT (a similar drug) to those taken after treatment with MT1621.
Insulin Sensitizer
Pioglitazone for Fatty Liver Disease
Recruiting3 awardsPhase 4
San Antonio, Texas
This trial studies the effects of pioglitazone, a medication that helps the body use insulin more effectively, in patients with type 2 diabetes who have liver conditions like NAFL or NASH. Pioglitazone is a safe and effective option to manage patients with type 2 diabetes and nonalcoholic steatohepatitis (NASH). The goal is to see if this treatment can improve liver function and control blood sugar levels. Researchers will measure various aspects of liver metabolism and insulin sensitivity before and after a few months of treatment.
Popular Filters
Trials With No Placebo
Device
Nanosensor for Mitochondrial Myopathy
Recruiting1 awardPhase 1
Philadelphia, Pennsylvania
This trial aims to test a new method using an electrochemical oxygen nanosensor to measure mitochondrial function in muscle tissue of patients with mitochondrial myopathy. The goal is to find a reliable way to determine
Behavioural Intervention
Exercise Therapy for Mitochondrial Disease
Recruiting1 awardPhase 1
Philadelphia, Pennsylvania
This trial will study the effects of exercise in patients with primary mitochondrial disease and healthy volunteers, as well as in patients admitted to the Pediatric Intensive Care Unit.
Antioxidant
N-Acetylcysteine for Mitochondrial Disease
Recruiting1 awardPhase 1
New York, New York
This trial will study the effects of N-acetylcysteine (NAC), an anti-oxidant, on brain glutathione levels, cognitive skills, motor skills, and quality of life. 18 participants will take either 1800, 3600 or 5400 mg per day of NAC for 3 months. The goal is to determine a safe and effective dose of NAC for a future clinical trial.
Quinone Analog
Vatiquinone Safety for Mitochondrial Disease
Recruiting2 awardsPhase 3
La Jolla, California
This trial is testing the safety of vatiquinone, a medication that helps cells produce energy, in people with inherited mitochondrial disease. These participants have already used vatiquinone in previous studies. The study will continue for an extended period. Vatiquinone, also known as EPI-743, is a new oral antioxidant that has been evaluated for mitochondrial diseases.
CombinationProduct
Deoxynucleoside Therapy for Mitochondrial Disease
Recruiting1 awardPhase 2
Montréal, Quebec
This trial tests a treatment using specific DNA building blocks to help children with a severe genetic disorder that affects energy production in their cells. The goal is to see if this treatment can improve their condition by restoring the function of their mitochondria.
Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.