Itraconazole for Esophageal Cancer
Recruiting1 awardPhase 2
Dallas, Texas
This trial tests if itraconazole, a drug for fungal infections, can help treat esophageal cancer. It targets patients with poor survival rates. The drug works by blocking growth signals in cancer cells. The trial will see if adding itraconazole after standard treatment improves outcomes. Itraconazole is an FDA-approved antifungal agent that has shown promising anticancer activities in recent years.
Monoclonal Antibodies
MEDI4736 + AZD9150/AZD5069 for Head & Neck Cancer
Recruiting1 awardPhase 1 & 2
Birmingham, Alabama
This trial is designed to study the safety and effectiveness of a new drug in people with a certain medical condition. It is split into two parts, with the first part focusing on safety and the second part focusing on effectiveness.
Flavonoid
Quercetin for Squamous Cell Cancer in Fanconi Anemia
Recruiting1 awardPhase 2
Cincinnati, Ohio
This trial is testing whether the supplement quercetin can prevent or delay the development of skin cancer in people with Fanconi anemia, a rare disease that leads to bone marrow failure and a higher risk for certain cancers.
Immunotherapy
IRX-2 Regimen + Durvalumab for Squamous Cell Carcinoma
Recruiting1 awardPhase 1
Tampa, Florida
This trial is testing a combination of treatments that boost the immune system and help it attack cancer cells. It targets patients with specific types of head and neck cancers that cannot be cured with standard treatments. The goal is to see if these treatments are safe and effective in improving the body's ability to fight cancer.
Popular Filters
Trials for Head And Neck Squamous Cell Carcinoma Patients
Virus Therapy
Photoimmunotherapy + Anti-PD1 for Head and Neck Cancer
Recruiting1 awardPhase 1 & 2
Lexington, Kentucky
This trial tests a new treatment combining a light-sensitive drug and an immune booster for patients with hard-to-treat head and neck or skin cancers. The goal is to see if this combination is safe and effective in shrinking tumors.
Alkylating agents
Chemotherapy + Bevacizumab for Head and Neck Cancers
Recruiting2 awardsPhase 3
Mobile, Alabama
This trial is testing chemotherapy with or without bevacizumab to see how well it works in treating patients with head and neck squamous cell carcinoma that has come back or spread to other parts of the body.
Radiation
Radiation Therapy + Cisplatin for Head and Neck Cancer
Recruiting1 awardPhase 2
Birmingham, Alabama
This trial is studying if using a specific type of energy treatment alone or with a drug is better for treating patients with advanced head and neck cancer after surgery. The energy treatment kills cancer cells, and the drug helps by stopping their growth or killing them. The drug has been used for many years in the treatment of advanced cancers, including head and neck cancers, and is known for its ability to enhance the effects of the energy treatment.
Trials for HNSCC Patients
Virus Therapy
Photoimmunotherapy + Anti-PD1 for Head and Neck Cancer
Recruiting1 awardPhase 1 & 2
Lexington, Kentucky
This trial tests a new treatment combining a light-sensitive drug and an immune booster for patients with hard-to-treat head and neck or skin cancers. The goal is to see if this combination is safe and effective in shrinking tumors.
Radiation
Radiation Therapy + Cisplatin for Head and Neck Cancer
Recruiting1 awardPhase 2
Birmingham, Alabama
This trial is studying if using a specific type of energy treatment alone or with a drug is better for treating patients with advanced head and neck cancer after surgery. The energy treatment kills cancer cells, and the drug helps by stopping their growth or killing them. The drug has been used for many years in the treatment of advanced cancers, including head and neck cancers, and is known for its ability to enhance the effects of the energy treatment.
Platinum-based Chemotherapy
CACTUX for Head and Neck Cancer
Recruiting1 awardPhase 2
Little Rock, Arkansas
This trial is testing a new cancer treatment called CACTUX. It's a combination of 3 drugs, and the investigators want to see if it's effective and has fewer side effects than the standard treatment.
Monoclonal Antibodies
Cetuximab + Interleukin-12 for Head and Neck Cancer
Recruiting1 awardPhase 1 & 2
Washington, District of Columbia
This trial is testing the side effects and best dose of a combination of two drugs to treat patients with head and neck squamous cell carcinoma that has come back or spread. The two drugs are recombinant interleukin-12 and cetuximab.
Trials for Metastatic Patients
Chemotherapy
Pembrolizumab + Olaparib for Head and Neck Cancer
Recruiting1 awardPhase 2
Chapel Hill, North Carolina
This trial will test whether using pembrolizumab and olaparib together before and after chemoradiation therapy is more effective in treating locally advanced head and neck squamous cell carcinoma than chemoradiation therapy alone.
Virus Therapy
Photoimmunotherapy + Anti-PD1 for Head and Neck Cancer
Recruiting1 awardPhase 1 & 2
Lexington, Kentucky
This trial tests a new treatment combining a light-sensitive drug and an immune booster for patients with hard-to-treat head and neck or skin cancers. The goal is to see if this combination is safe and effective in shrinking tumors.
Alkylating agents
Chemotherapy + Bevacizumab for Head and Neck Cancers
Recruiting2 awardsPhase 3
Mobile, Alabama
This trial is testing chemotherapy with or without bevacizumab to see how well it works in treating patients with head and neck squamous cell carcinoma that has come back or spread to other parts of the body.
Radiation
Radiation Therapy + Cisplatin for Head and Neck Cancer
Recruiting1 awardPhase 2
Birmingham, Alabama
This trial is studying if using a specific type of energy treatment alone or with a drug is better for treating patients with advanced head and neck cancer after surgery. The energy treatment kills cancer cells, and the drug helps by stopping their growth or killing them. The drug has been used for many years in the treatment of advanced cancers, including head and neck cancers, and is known for its ability to enhance the effects of the energy treatment.
Trials for P16 Positive Patients
Chemotherapy
Pembrolizumab + Olaparib for Head and Neck Cancer
Recruiting1 awardPhase 2
Chapel Hill, North Carolina
This trial will test whether using pembrolizumab and olaparib together before and after chemoradiation therapy is more effective in treating locally advanced head and neck squamous cell carcinoma than chemoradiation therapy alone.
Palbociclib + Chemoradiation for Head and Neck Cancer
Recruiting1 awardPhase 2
Saint Louis, Missouri
This trial is testing a new cancer treatment that involves taking a drug called palbociclib before and after chemoradiation, to see if it improves outcomes for people with HPV-unrelated head and neck squamous cell carcinoma.
PD-1 Inhibitor
Pembrolizumab + Radiotherapy for Head and Neck Cancer
Recruiting2 awardsPhase 3
La Jolla, California
This trial is testing whether adding pembrolizumab to radiotherapy (with or without cisplatin) before and after surgery improves outcomes in people with newly diagnosed, resectable head and neck squamous cell carcinoma.
Trials for PD-L1 Positive Patients
Virus Therapy
Photoimmunotherapy + Anti-PD1 for Head and Neck Cancer
Recruiting1 awardPhase 1 & 2
Lexington, Kentucky
This trial tests a new treatment combining a light-sensitive drug and an immune booster for patients with hard-to-treat head and neck or skin cancers. The goal is to see if this combination is safe and effective in shrinking tumors.
Alkylating agents
Pembrolizumab + Radiation vs Chemotherapy + Radiation for Head and Neck Cancer
Recruiting1 awardPhase 2
Gainesville, Florida
This trial is testing pembrolizumab, a monoclonal antibody, in combination with radiation therapy or pembrolizumab alone compared to the usual approach of chemotherapy plus radiation therapy after surgery in treating patients with head and neck squamous cell carcinoma that has come back or patients with a second head and neck cancer that is not from metastasis.
PD-L1 Inhibitor
Triple Drug Combo for Head and Neck Cancer
Recruiting0 awardsPhase 2
Duarte, California
This trial is testing a new combination of drugs to treat a specific type of head and neck cancer. The treatment includes retifanlimab, which helps the immune system attack cancer, combined with other experimental drugs to enhance this effect. It targets patients whose cancer has come back or spread and who haven't received other treatments yet. Retifanlimab is an immunotherapy drug that helps the immune system attack cancer cells.
Phase 3 Trials
Immune Response Modifier
Imiquimod Cream for Basal Cell Carcinoma
Recruiting3 awardsPhase 3
Providence, Rhode Island
This trial will compare Imiquimod vs. placebo cream for preventing basal cell carcinoma of the skin on the face. 1630 Veterans at high risk of BCC will be recruited from 17 VA medical centers.
Alkylating agents
Chemotherapy + Bevacizumab for Head and Neck Cancers
Recruiting2 awardsPhase 3
Mobile, Alabama
This trial is testing chemotherapy with or without bevacizumab to see how well it works in treating patients with head and neck squamous cell carcinoma that has come back or spread to other parts of the body.
PD-1 Inhibitor
Pembrolizumab + Radiotherapy for Head and Neck Cancer
Recruiting2 awardsPhase 3
La Jolla, California
This trial is testing whether adding pembrolizumab to radiotherapy (with or without cisplatin) before and after surgery improves outcomes in people with newly diagnosed, resectable head and neck squamous cell carcinoma.
Trials With No Placebo
Chemotherapy
Pembrolizumab + Olaparib for Head and Neck Cancer
Recruiting1 awardPhase 2
Chapel Hill, North Carolina
This trial will test whether using pembrolizumab and olaparib together before and after chemoradiation therapy is more effective in treating locally advanced head and neck squamous cell carcinoma than chemoradiation therapy alone.
Virus Therapy
Photoimmunotherapy + Anti-PD1 for Head and Neck Cancer
Recruiting1 awardPhase 1 & 2
Lexington, Kentucky
This trial tests a new treatment combining a light-sensitive drug and an immune booster for patients with hard-to-treat head and neck or skin cancers. The goal is to see if this combination is safe and effective in shrinking tumors.
View More Related Trials
Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.