Glioblastoma Clinical Trials in Baltimore, MD

View the best 10 glioblastoma medical studies in Baltimore, Maryland. Access promising new therapies by applying to a Baltimore-based Glioblastoma clinical trial.

Trials in Baltimore, Maryland

Here are the top 10 medical studies for glioblastoma in Baltimore, Maryland

Michael Bask Gill, B Sc

Last Reviewed: December 14th, 2024

Exablate Model 4000

Focused Ultrasound

Recruiting1 award

This trial aims to test the safety and effectiveness of using the Exablate device to temporarily open the blood-brain barrier in patients with suspected Glioblastoma. By doing this, doctors can collect fluid from the brain to check for cancer cells. The study will take place at up to 25 centers in the US.

TheraSphere GBM

Brachytherapy

Recruiting1 awardPhase < 1

This trial is testing a new radiation treatment using tiny radioactive beads for patients with aggressive brain cancer that has come back. The treatment aims to target the tumor more precisely and reduce side effects compared to standard treatments. GammaTile is a device that uses cesium-131 radiation-emitting seeds embedded in a collagen tile to provide targeted radiation therapy for brain tumors.

Fimepinostat

Histone Deacetylase (HDAC) Inhibitor

Recruiting1 awardPhase < 1

This trial is testing how well fimepinostat works in treating patients with newly diagnosed brain tumors. Fimepinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Carboplatin

Chemotherapy

Recruiting2 awardsPhase 3

This trial tests a new method to treat recurrent brain cancer using an ultrasound device called SonoCloud-9. The device helps open the brain's protective barrier so that more of the chemotherapy drug carboplatin can reach the tumor. The goal is to see if this combination makes the treatment more effective. Carboplatin has been used in various studies for treating high-grade gliomas and glioblastomas, often showing modest efficacy due to low tissue concentration when delivered intravenously.

Lomustine +2 More

Alkylating agents

Recruiting2 awardsPhase 3

This trial is comparing the effect of adding lomustine to temozolomide and radiation therapy versus temozolomide and radiation therapy alone in treating newly diagnosed MGMT methylated glioblastoma.

APL-101

Small Molecule Inhibitor

Recruiting1 awardPhase 2

This trial is testing APL-101, a new drug, on patients with specific genetic changes in their cancer. These patients often don't respond to typical treatments. The drug aims to block a protein that helps cancer cells grow and spread.

P140K-MGMT +3 More

Virus Therapy

Recruiting1 awardPhase 2

This trial is studying the effect of giving P140K MGMT hematopoietic stem cells, O6-benzylguanine, temozolomide, and carmustine to people with supratentorial glioblastoma or gliosarcoma who have recently had surgery to remove most or all of the brain tumor (resected).

SurVaxM

Cancer Vaccine

Recruiting1 awardPhase 1

This trial tests the SurVaxM vaccine, which helps the immune system target and destroy cancer cells, in children and young adults with certain difficult-to-treat brain cancers. The vaccine works by teaching the immune system to recognize a protein found in cancer cells. Additional substances are used to make the immune response stronger.

Hypofractionation Trial of Re-irradiation

Radiation

Recruiting1 awardPhase 1

This trial aims to find a safe schedule for using radiation to treat brain tumors (GBM) that have returned after initial radiation treatment. Participants in the trial will undergo re-irradiation planning where

BDTX-1535

Small Molecule Inhibitor

Recruiting1 awardPhase 1 & 2

This trial is testing a new drug for people with glioblastoma or non-small cell lung cancer who have disease progression following standard of care.

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Brachytherapy

TheraSphere for Recurrent Brain Cancer

Recruiting1 awardPhase < 1

Baltimore, Maryland

This trial is testing a new radiation treatment using tiny radioactive beads for patients with aggressive brain cancer that has come back. The treatment aims to target the tumor more precisely and reduce side effects compared to standard treatments. GammaTile is a device that uses cesium-131 radiation-emitting seeds embedded in a collagen tile to provide targeted radiation therapy for brain tumors.

Small Molecule Inhibitor

BDTX-1535 + Temozolomide for Glioblastoma and Lung Cancer

Recruiting1 awardPhase 1 & 2

Washington, District of Columbia

This trial is testing a new drug for people with glioblastoma or non-small cell lung cancer who have disease progression following standard of care.

CAR T-cell Therapy

CAR T-cell Therapy for Glioblastoma

Recruiting1 awardPhase 1

Philadelphia, Pennsylvania

This trial tests safety and effectiveness of new cell therapy for glioblastoma brain tumors that have come back after treatment.

Metabolic Modulator

DCA for Glioblastoma

Recruiting1 awardPhase 2

Baltimore, Maryland

This trial tests if DCA, a medication taken by mouth, can help treat patients with returning brain tumors who are scheduled for surgery. DCA may change how tumor cells use energy, potentially slowing their growth. DCA has shown potential activity against several human cancers, including brain tumors.

Selective Inhibitors of Nuclear Export

Selinexor + Radiation for Brain Cancer

Recruiting1 awardPhase 1 & 2

Baltimore, Maryland

This trial tests the safety and effectiveness of combining selinexor with radiation therapy in children and young adults with aggressive brain tumors. Selinexor is a drug that blocks a protein to stop cancer cells from growing. The study aims to find the best dose and see if this combination can shrink tumors.

Alkylating agents

Lomustine + Standard Therapy for Glioblastoma

Recruiting2 awardsPhase 3

Baltimore, Maryland

This trial is comparing the effect of adding lomustine to temozolomide and radiation therapy versus temozolomide and radiation therapy alone in treating newly diagnosed MGMT methylated glioblastoma.

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Frequently Asked Questions

Do I need insurance to participate in a trial?

Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).

Is there any support for travel costs?

Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.

Will I know what medication I am taking?

This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.

How long do clinical trials last?

Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.

Do you verify all the trials on your website?

All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.

How quickly will I hear back from a clinical trial?

Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.