Trials in Philadelphia, Pennsylvania
Here are the top 10 medical studies for glioblastoma in Philadelphia, Pennsylvania
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Phase 3 Trials
Chemotherapy
Ultrasound-Assisted Chemotherapy for Glioblastoma
Recruiting2 awardsPhase 3
New York, New York
This trial tests a new method to treat recurrent brain cancer using an ultrasound device called SonoCloud-9. The device helps open the brain's protective barrier so that more of the chemotherapy drug carboplatin can reach the tumor. The goal is to see if this combination makes the treatment more effective. Carboplatin has been used in various studies for treating high-grade gliomas and glioblastomas, often showing modest efficacy due to low tissue concentration when delivered intravenously.
Alkylating agents
Lomustine + Standard Therapy for Glioblastoma
Recruiting2 awardsPhase 3
Allentown, Pennsylvania
This trial is comparing the effect of adding lomustine to temozolomide and radiation therapy versus temozolomide and radiation therapy alone in treating newly diagnosed MGMT methylated glioblastoma.
Radiation
Personalized Immunotherapy for Glioblastoma
Recruiting1 awardPhase 2 & 3
Newark, New Jersey
This trial will study an immunotherapy combining a cancer-patient's own cells and standard treatment to fight glioblastoma. Immune cells will be harvested from the patient, stimulated and expanded, then infused back.
Chemotherapy
Optune + Temozolomide + Pembrolizumab for Brain Cancer
Recruiting1 awardPhase 3
New York, New York
This trial is testing a treatment for newly diagnosed brain cancer patients. They are comparing the effectiveness of a new treatment called Optune with chemotherapy and immunotherapy to a combination of Optune with chemotherapy alone.
Intraoperative Radiotherapy for Glioblastoma
Recruiting2 awardsPhase 3
New York, New York
This trial is testing if adding intraoperative radiotherapy (IORT) to standard radiochemotherapy can improve the median progression-free survival (PFS) of patients with newly diagnosed glioblastoma multiforme (GBM).
Trials With No Placebo
mTOR Inhibitor
Ribociclib + Everolimus for Brain Tumors
Recruiting1 awardPhase 2
Philadelphia, Pennsylvania
This trial is testing whether the combination of ribociclib and everolimus can help children and young adults with aggressive brain tumors live longer. Everolimus is a medication that has been approved for treating various cancers. These drugs are taken by mouth and work by stopping cancer cells from growing. The study focuses on patients whose tumors have specific genetic changes that make them hard to treat with standard therapies.
Brachytherapy
TheraSphere for Recurrent Brain Cancer
Recruiting1 awardPhase < 1
New York, New York
This trial is testing a new radiation treatment using tiny radioactive beads for patients with aggressive brain cancer that has come back. The treatment aims to target the tumor more precisely and reduce side effects compared to standard treatments. GammaTile is a device that uses cesium-131 radiation-emitting seeds embedded in a collagen tile to provide targeted radiation therapy for brain tumors.
Monoclonal Antibodies
Tocilizumab + Atezolizumab + Radiation Therapy for Glioblastoma
Recruiting1 awardPhase 2
Philadelphia, Pennsylvania
This trial tests a combination of tocilizumab, atezolizumab, and precise radiation therapy in patients with recurrent glioblastoma. Tocilizumab reduces inflammation, atezolizumab boosts the immune system, and the radiation targets the tumor. The goal is to make the tumor more responsive to treatment and improve patient outcomes.
Radiation
Dabrafenib + Trametinib After Radiation for Brain Cancer
Recruiting1 awardPhase 2
Philadelphia, Pennsylvania
This trial studies how well dabrafenib and trametinib work after radiation therapy in children and young adults with a specific type of brain tumor. These drugs help stop tumor growth by blocking signals that tell the cells to multiply. Dabrafenib has been developed and tested extensively for a specific type of skin cancer, showing effectiveness both alone and when used with trametinib.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.