Popular Trials
Monoclonal Antibodies
Lonigutamab for Thyroid Eye Disease
This trial is testing a new medication called lonigutamab to help people with Thyroid Eye Disease (TED). TED causes eye problems due to thyroid issues. Lonigutamab may work by reducing inflammation and other symptoms in the eyes.
Corticosteroid
Dexamethasone for Autoimmune Thyroid Disease
This trial is testing whether giving patients anti-inflammatory medication (corticosteroids) before thyroid surgery can reduce gland inflammation and make the surgery easier. The focus is on patients with autoimmune thyroid disease, where the immune system attacks the thyroid, causing inflammation.
Monoclonal Antibodies
Teprotumumab for Thyroid Eye Disease
This trial tests the safety and effectiveness of teprotumumab, an IV medication, in adults with Thyroid Eye Disease. It aims to find the best treatment period and assess the need for additional treatment. The medication helps by reducing inflammation and tissue changes in the eyes. Teprotumumab, initially developed for tumor treatment, was later repurposed for thyroid eye disease and approved by the USFDA.
Anti-VEGF Therapy
Anti-VEGF Therapy for Thyroid Eye Disease
This trial is testing the safety of injecting a medication called aflibercept, mixed with either a saltwater solution or an enzyme, around the eyes of patients with acute Thyroid Eye Disease. The goal is to see if this treatment can safely reduce swelling and inflammation. Patients will receive multiple injections and be monitored for any side effects. Aflibercept has been used in various retinal diseases, including macular edema and age-related macular degeneration.
Monoclonal Antibodies
Teprotumumab for Graves' Eye Disease
This trial involves testing a new treatment for proptosis in a blinded study where some participants will receive the treatment and others will receive a placebo. Participants who do not respond to the initial treatment may have
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Phase 3 Trials
Monoclonal Antibodies
Batoclimab for Thyroid Eye Disease
This trial is an extension study for participants who have completed earlier studies. There are two groups in the study: an observational group and a treatment group. The observational group will look at how long the improvement
Monoclonal Antibodies
Batoclimab for Graves' Eye Disease
This trial tests batoclimab, a medication given as weekly injections under the skin, to see if it can help reduce eye bulging in patients with proptosis. The treatment starts with a higher dose for a few months, followed by a lower dose for a few more months. Batoclimab works by adjusting the immune system to decrease inflammation and swelling around the eyes.
Small Molecule Inhibitor
Linsitinib for Thyroid Eye Disease
This trial studies the safety and effectiveness of linsitinib, an oral medication taken regularly, in patients with moderate to severe thyroid eye disease. Linsitinib works by blocking a protein that contributes to the disease, aiming to reduce symptoms and improve eye health.
Trials With No Placebo
Monoclonal Antibodies
Batoclimab for Thyroid Eye Disease
This trial is an extension study for participants who have completed earlier studies. There are two groups in the study: an observational group and a treatment group. The observational group will look at how long the improvement
Cervical Collar Device for Thyroid Disorders
This trial is testing a device that is worn around the neck and measures radioiodine exposure to help estimate the amount of iodine-131 that a person needs for treatment of thyroid disorders while minimizing risks of comorbidities.
Tyrosine Kinase Inhibitor
Linsitinib for Thyroid Eye Disease
This trial is testing linsitinib, a medication, on patients who did not improve or got worse after previous treatment. The goal is to see if linsitinib can help these patients by blocking certain proteins that make their condition worse.
Antiviral
Kamuvudine-9 for Thyroid Eye Disease
This trial aims to study how the drug K9 moves through the body in healthy individuals and its safety and effectiveness in patients with Thyroid Eye Disease. Participants will take the medication once or for up to
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Frequently Asked Questions
Introduction to graves disease
What are the top hospitals conducting graves disease research?
In the realm of clinical trials for Graves' disease, one hospital stands out as a pioneer in research and treatment. Located in Baltimore, Maryland, Johns Hopkins Hospital has taken up the mantle to tackle this complex autoimmune disorder. While they currently have just one active trial dedicated to Graves' disease, it is a significant step forward in understanding and finding potential solutions for this condition. The hospital's commitment to advancing medical knowledge is evident as they recorded their first-ever trial for Graves' disease in 2018.
Graves' disease is an autoimmune disorder that affects the thyroid gland, leading to its overactivity and resulting in symptoms such as weight loss, rapid heartbeat, anxiety, and bulging eyes (a condition called exophthalmos). It primarily affects women between the ages of 20 and 40 but can also occur in men and children.
Johns Hopkins Hospital's involvement in researching Graves' disease highlights the importance of continuous exploration into rare or lesser-known conditions. By conducting clinical trials focused specifically on this ailment, researchers aim to improve our understanding of its underlying mechanisms and develop effective treatments. Through their efforts at Johns Hopkins Hospital - renowned for its expertise across various medical disciplines - patients with Graves' disease can find hope not only through cutting-edge care but also through groundbreaking research paving the way towards better management strategies.
Which are the best cities for graves disease clinical trials?
When it comes to graves disease clinical trials, Baltimore, Maryland emerges as a leading city in research and development. With 1 active trial underway, the city focuses on important investigations such as the Pilot Project and other promising interventions. This commitment to advancing knowledge and treatment options for graves disease brings hope to patients seeking innovative approaches in managing their condition.
Which are the top treatments for graves disease being explored in clinical trials?
Graves disease, a thyroid disorder affecting thousands of individuals worldwide, is the focus of ongoing clinical trials exploring innovative treatment options. Among the top treatments being investigated are:
- Teprotumumab: This drug shows promise in alleviating Graves' ophthalmopathy symptoms and has demonstrated positive results in multiple trials.
- Rituximab: An immunosuppressive medication commonly used to treat other autoimmune conditions, it is being tested for its efficacy in managing Graves disease as well.
- Tocilizumab: Originally developed for rheumatoid arthritis, this biologic agent is now being evaluated for its potential benefits in treating Graves' orbitopathy.
Through these clinical trials, researchers aim to advance medical knowledge and offer new avenues of hope for those affected by Graves disease.
What are the most recent clinical trials for graves disease?
In recent clinical trials, promising advancements have been made in the treatment of Graves' disease. Researchers are investigating new therapies and approaches to better manage this autoimmune disorder. One study focuses on the use of novel immunomodulatory drugs to target specific pathways involved in the development of Graves' disease. Another trial explores the potential benefits of complementary treatments like acupuncture or herbal medicine as adjunctive therapies for symptom relief. These ongoing studies offer hope for improved outcomes and quality of life for individuals living with Graves' disease.
What graves disease clinical trials were recently completed?
Recently, several clinical trials focusing on the treatment of Graves' disease have successfully concluded. These studies signify significant progress in combating this autoimmune disorder. Notably, a trial sponsored by Roche Pharmaceuticals investigated the efficacy and safety of their experimental drug RVT-1401 and was completed in November 2021. Another trial conducted by Eli Lilly and Company assessed the effectiveness of their medication LY3337641 and wrapped up in September 2020. These recent developments highlight the ongoing efforts to improve therapies for individuals with Graves' disease, offering hope for better management of this condition in the future.