Angiotensin II Receptor Blocker, COX-2 Inhibitor, Biguanide
Valsartan + Celecoxib + Metformin for Type 2 Diabetes
This trial is evaluating the safety, tolerability and superiority of RK-01, a valsartan plus celecoxib dual add-on to metformin-HCL XR over metformin in newly diagnosed and obese adult type 2 diabetes patients with high blood pressure, arthritis and inadequate glycemic control with metformin monotherapy, diet and exercise. The objective is to assess the effect of RK-01 on hemoglobin A1c (HbA1c) levels, beta cell function and insulin resistance with co-administration of valsartan, celecoxib and metformin-HCl X
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Trials for High Blood Pressure Patients
Device
Renal Denervation for High Blood Pressure
This trial is testing whether a treatment called renal denervation can help lower blood pressure in people who have uncontrolled hypertension. The trial will compare people who receive the treatment to those who don't, and will be conducted via central randomization.
Trials for HBP Patients
Device
Renal Denervation for High Blood Pressure
This trial is testing whether a treatment called renal denervation can help lower blood pressure in people who have uncontrolled hypertension. The trial will compare people who receive the treatment to those who don't, and will be conducted via central randomization.
Phase 3 Trials
Endothelin Receptor Antagonist
Macitentan for Pulmonary Hypertension
This trial is testing macitentan, a drug that helps lower lung blood pressure, in children with pulmonary arterial hypertension. Macitentan has shown significant effectiveness in improving the condition of patients with pulmonary arterial hypertension.
Device
Renal Denervation for High Blood Pressure
This trial is testing whether a treatment called renal denervation can help lower blood pressure in people who have uncontrolled hypertension. The trial will compare people who receive the treatment to those who don't, and will be conducted via central randomization.
Endothelin Receptor Antagonist
High-Dose Macitentan for PAH
This trial is testing if a higher dose of macitentan can better help patients with pulmonary arterial hypertension by improving blood flow in their lungs. Macitentan has shown promise in helping patients by slowing down the disease and improving their health.
Trials With No Placebo
Endothelin Receptor Antagonist
Macitentan for Pulmonary Hypertension
This trial is testing macitentan, a drug that helps lower lung blood pressure, in children with pulmonary arterial hypertension. Macitentan has shown significant effectiveness in improving the condition of patients with pulmonary arterial hypertension.
Angiotensin Receptor Blocker/Neprilysin Inhibitor
Combination Blood Pressure Therapy for High Blood Pressure
This trial is testing if a two-drug combination can increase blood flow more than one of the drugs can on its own, and if a third drug can interact with the first two to also increase blood flow.
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Frequently Asked Questions
Introduction to high blood pressure
What are the top hospitals conducting high blood pressure research?
In the battle against high blood pressure, several leading hospitals across the United States have stepped up to conduct groundbreaking clinical trials. Duke University Medical Center in Durham, North carolina is at the forefront of this research with seven ongoing trials dedicated to studying this condition. Renowned for its expertise in cardiovascular health, Duke's commitment to finding innovative solutions for high blood pressure is evident. Similarly, Vanderbilt University Medical Center in Nashville and Washington University School of Medicine in Saint Louis are making significant contributions with their own active trials focused on combating high blood pressure.
Meanwhile, Massachusetts General Hospital in Boston brings its renowned medical prowess into play by actively conducting six clinical trials centered around managing this prevalent condition that affects millions nationwide. Notably contributing to the advancement of hypertension research as well is the University of Kansas Medical Center situated conveniently within Kansas City's medical landscape where they currently undertake six simultaneous investigations aiming towards better understanding and treatment options for those grappling with high blood pressure.
With each hospital focusing on distinct aspects related to high blood pressure management, these institutions represent beacons of hope for patients and families affected by this silent but potentially devastating condition. The collective efforts of researchers and healthcare professionals across these top hospitals signal a promising future where improved strategies can be developed to prevent and manage hypertension effectively
Which are the best cities for high blood pressure clinical trials?
When it comes to high blood pressure clinical trials, several cities emerge as prominent hubs for research. Boston, Massachusetts leads the way with 35 active trials investigating treatments like Ralinepag, Macitentan, and Sotatercept. Los Angeles, California follows closely behind with 30 ongoing studies focused on interventions such as Ralinepag and AV-101. Philadelphia, Pennsylvania also plays a significant role in advancing knowledge about high blood pressure through its 19 active trials exploring options like Ralinepag and Treprostinil Inhalation Powder. These cities provide valuable opportunities for individuals seeking innovative approaches to manage their condition and contribute to the development of improved treatments for high blood pressure.
Which are the top treatments for high blood pressure being explored in clinical trials?
Clinical trials are paving the way for new breakthroughs in the treatment of high blood pressure. Among the leading candidates being explored, we have:
- Daratumumab: 6 active trials
- Belantamab mafodotin: 4 active trials
- Lenalidomide: 3 active trials
These treatments show significant potential and are currently undergoing rigorous testing to determine their effectiveness in managing high blood pressure. Researchers remain dedicated to finding innovative solutions that can improve the lives of individuals with this condition.
What are the most recent clinical trials for high blood pressure?
Promising developments in the treatment of high blood pressure have emerged from recent clinical trials. One notable trial evaluated the efficacy of a contact lens embedded with Latanoprost, demonstrating its potential as an innovative approach to managing this condition. Furthermore, diuretic augmentation using hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide has shown promising results as an adjunct therapy for individuals with high blood pressure. Additionally, empowering patients through self-management of BP medications and exploring new dosing strategies are areas being actively explored to optimize treatment outcomes. These advancements provide renewed hope for better management and control of high blood pressure moving forward.
What high blood pressure clinical trials were recently completed?
High blood pressure clinical trials have recently concluded, showcasing advancements in the field of hypertension management. One such trial was completed by Stanford University School of Medicine, investigating the effects of a novel medication on reducing blood pressure. Another significant study conducted by the National Heart, Lung, and Blood Institute focused on evaluating lifestyle interventions for individuals with high blood pressure. These recent achievements signify progress in improving treatment options and enhancing patient outcomes in managing this prevalent condition.