Herbal Supplement
Aloe Vera Capsules for Interstitial Cystitis
This trial is testing whether strong, dried aloe vera capsules can help people with interstitial cystitis, a painful bladder condition. Aloe vera is known for its soothing effects and might reduce inflammation and pain. Participants will take increasing doses of the capsules over several months to see if their symptoms improve.
Procedure
Nerve Stimulation Therapy for Bladder Pain Syndrome
"This trial aims to test whether using electrical micro-current on a group of nerves can improve bladder pain syndrome (BPS) in women. Participants will undergo a procedure involving short bursts of electrical energy directed at
IW-3300 for Interstitial Cystitis
This trial is testing a new drug called IW-3300 to see if it can help people with chronic bladder pain. The drug is given as a rectal foam and aims to relieve symptoms like pain, burning, and pressure. Patients will use the drug at home for a few months.
Local Anesthetic and Anticoagulant
VNX001 for Interstitial Cystitis
This trial tests VNX001, a combination of heparin and lidocaine, to help patients with chronic bladder pain from IC/BPS. Heparin repairs the bladder lining, and lidocaine numbs the bladder to reduce pain. These treatments are commonly used to manage IC/BPS symptoms.
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Trials for IC Patients
Behavioral Intervention
Pelvic Floor Physical Therapy + Psychosocial Treatment for Bladder Pain Syndrome
"This trial aims to understand how different subgroups of patients with interstitial cystitis/bladder pain syndrome respond to two common treatments - pelvic floor physical therapy and cognitive-behavioral therapy. The goal
Procedure
Amniotic Membrane Therapy for Interstitial Cystitis
This trial aims to see if using amniotic membrane therapy can help improve symptoms in patients with interstitial cystitis/painful bladder syndrome (IC/PBS), which causes bladder and/or pelvic pain
Electromagnetic Therapy
PEMF Therapy for Bladder Infection
This trial is testing a non-drug treatment called PEMF therapy on women with chronic bladder and pelvic pain. The therapy uses electromagnetic fields to reduce pain and improve symptoms. Researchers aim to see if it is safe and effective over several months. Pulsed electromagnetic field (PEMF) therapy has been shown to reduce tissue inflammation and improve symptoms in conditions like benign prostatic hyperplasia (BPH).
Neuromodulation
rTMS for Interstitial Cystitis
This trial uses magnetic pulses to stimulate the brain in women with chronic bladder pain. The goal is to reduce pain and muscle issues by improving brain function. The study will involve 50 women. Pulsed electromagnetic field (PEMF) therapy has been studied for its potential to reduce pain and improve quality of life in various conditions, including chronic pain syndromes.
Trials for Painful Bladder Syndrome Patients
Behavioral Intervention
Pelvic Floor Physical Therapy + Psychosocial Treatment for Bladder Pain Syndrome
"This trial aims to understand how different subgroups of patients with interstitial cystitis/bladder pain syndrome respond to two common treatments - pelvic floor physical therapy and cognitive-behavioral therapy. The goal
Procedure
Amniotic Membrane Therapy for Interstitial Cystitis
This trial aims to see if using amniotic membrane therapy can help improve symptoms in patients with interstitial cystitis/painful bladder syndrome (IC/PBS), which causes bladder and/or pelvic pain
Electromagnetic Therapy
PEMF Therapy for Bladder Infection
This trial is testing a non-drug treatment called PEMF therapy on women with chronic bladder and pelvic pain. The therapy uses electromagnetic fields to reduce pain and improve symptoms. Researchers aim to see if it is safe and effective over several months. Pulsed electromagnetic field (PEMF) therapy has been shown to reduce tissue inflammation and improve symptoms in conditions like benign prostatic hyperplasia (BPH).
Trials With No Placebo
Behavioral Intervention
Pelvic Floor Physical Therapy + Psychosocial Treatment for Bladder Pain Syndrome
"This trial aims to understand how different subgroups of patients with interstitial cystitis/bladder pain syndrome respond to two common treatments - pelvic floor physical therapy and cognitive-behavioral therapy. The goal
ICE-MRI Bladder Permeability Assay for Interstitial Cystitis
This trial studies if MRI scans can distinguish different types of Interstitial Cystitis/Bladder Pain Syndrome. Participants will be given an MRI test with radio waves and a powerful magnet to look at the bladder. They will also have a sterile catheter placed in the bladder with fluids to help with the MRI.
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Frequently Asked Questions
Introduction to interstitial cystitis
What are the top hospitals conducting interstitial cystitis research?
When it comes to the treatment and research of interstitial cystitis, several hospitals are leading the way in advancing our understanding and finding potential solutions for this challenging condition. In Winston-Salem, North carolina, Wake Forest University Health Sciences is at the forefront with three active interstitial cystitis trials and a total of four conducted trials since their first recorded investigation in 2015. Meanwhile, William Beaumont Hospital in Royal Oak, Michigan has been dedicated to studying this condition since 2004 and currently has two ongoing clinical trials along with an impressive history of 19 completed studies.
In Philadelphia, the Pelvic and Sexual Health Institute is making strides with two active interstitial cystitis trials. Although they have conducted only three previous investigations since recording their first trial in 2007, their commitment to understanding this complex disorder remains unwavering.
Closer to home for those residing in Winston-Salem is Atrium Health Wake Forest Baptist Health. While still relatively new to conducting clinical trials on interstitial cystitis with just one active trial at present, their determination shines through as they recorded their first-ever trial for this condition scheduled for 2023.
Lastly but certainly not least, Urology Centers of Alabama (ID#243600) located in Homewood contributes significantly by actively engaging themselves into one current trial related to Interstitial Cystitis while having accomplished a single study previously from its initiation backdated until2022; these small-scale efforts signify valuable contributions towards solving mysteries surrounding this chronic bladder disorder that affects countless individuals worldwide.
These hospitals exemplify dedication and innovation when it comes to researching treatments for interstitial cystitis. The collaborative efforts between medical professionals at these institutions give hope that improved options will be available soon for those suffering from this often debilitating condition
Which are the best cities for interstitial cystitis clinical trials?
When it comes to interstitial cystitis clinical trials, several cities emerge as leaders in research. Los Angeles, California has 11 active trials investigating treatments like AQX-1125 100 mg and IW-3300 300 µg among others. Winston-Salem, North carolina follows closely behind with nine ongoing studies focusing on interventions such as Pulsed Electromagnetic Field treatment with intravesical bupivacaine/heparin instillations and Auricular Acupressure (AA). San Diego, California also contributes significantly with seven active trials exploring options like Lidocaine and BOTOX. These cities offer individuals living with interstitial cystitis access to cutting-edge clinical trials that pave the way for advancements in care and improved quality of life.
Which are the top treatments for interstitial cystitis being explored in clinical trials?
Clinical trials are shedding light on promising treatments for interstitial cystitis, a condition that causes chronic bladder pain. Here are the leading contenders currently being explored:
- Botox: With several ongoing trials, Botox injections show potential in managing interstitial cystitis symptoms.
- Cyclosporine: This immunosuppressive drug is undergoing clinical investigation and may offer relief to patients battling this debilitating condition.
- PPS (Pentosan Polysulfate Sodium): Multiple trials are examining the efficacy of PPS in alleviating the symptoms of interstitial cystitis.
As researchers delve deeper into these treatment options through clinical trials, hope continues to grow for individuals suffering from interstitial cystitis.
What are the most recent clinical trials for interstitial cystitis?
Recent clinical trials offer hope for individuals suffering from interstitial cystitis, a chronic condition that affects the bladder. Among these trials is Lidocaine, which has entered Phase 2 testing and shows potential as a treatment option. Another promising candidate is IW-3300 at a dosage of 300 µg, also in Phase 2 development. Additionally, a Phase 3 trial focusing on multimodal care bundles aims to provide comprehensive management strategies for interstitial cystitis patients. While BOTOX has completed its Phase 2 testing phase and showed promise in addressing symptoms associated with this condition, peppermint oil is undergoing both Phase 1 and Phase 2 studies. These recent developments bring new possibilities for improved quality of life among those affected by interstitial cystitis.
What interstitial cystitis clinical trials were recently completed?
A recent clinical trial investigating the efficacy of low-dose naltrexone in treating interstitial cystitis has concluded. Sponsored by NorthShore University HealthSystem, the trial was completed in September 2021. This study represents a significant step forward in understanding and potentially improving treatment options for individuals with interstitial cystitis, a chronic condition characterized by bladder pain and discomfort.