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Trials With No Placebo
Procedure
Ketamine + Propofol for Traumatic Brain Injury
This trial will test if using a combination of ketamine and propofol is safe for sedating patients with severe traumatic brain injury in the intensive care unit, compared to the standard sedation method.
Procedure
External Lumbar Drainage for Traumatic Brain Injury
This trial explores if ELD is safe & feasible for severe TBI patients without increasing risk of neurological worsening or herniation. Researchers will compare groups to see effects on raised intracranial pressure.
Procedure
Stealth-Guided EVD Placement for Intracranial Hypertension
This trial compares traditional freehand placement of brain catheters with a new method using the AxiEM Stealth image guidance system. The goal is to see if using detailed images from CT or MRI scans can help doctors place the catheters more accurately and safely in patients with conditions like hydrocephalus or brain trauma.
Stent
Venous Sinus Stenting for Intracranial Hypertension
This trial tests if placing a small tube (stent) in a brain vein can safely help patients with severe headaches or vision problems due to high brain pressure. These patients haven't improved with medication. The stent works by keeping the vein open to reduce pressure. This method has shown promising results in patients who haven't responded to other treatments.
Frequently Asked Questions
Introduction to intracranial hypertension
What are the top hospitals conducting intracranial hypertension research?
When it comes to clinical trials focused on intracranial hypertension, several esteemed hospitals are taking the lead. In Fort Sam Houston, Texas, Brooke Army Medical Center is at the forefront of this research with one active trial and a pioneering history of conducting their first trial in 2023. Similarly, the University of Texas in San Antonio is making significant contributions with one ongoing intracranial hypertension trial and an impressive track record of initiating their first study in 2023. Moving eastward to Aurora, Colorado, UCHealth Sue Anschutz-Rodgers Eye Center - Anschutz Medical Campus has also embarked on groundbreaking research with one active clinical trial for this condition and a noteworthy achievement in starting their initial investigation back in 2022.
Furthermore, Neuro-Eye Clinical Trials Inc., located in Houston, plays a vital role by conducting cutting-edge research on intracranial hypertension through its ongoing trial as well as recording its first-ever investigation into this field also occurring around 2022. Lastly but certainly not least is the Bascom Palmer Eye Institute within the University of Miami Leonard M. Miller School of Medicine (UMMSM). This renowned institution based in sunny Miami boasts one current intracranial hypertension clinical trial alongside previous accomplishments that include being among those who commenced comprehensive studies from as early as 2022.
These dedicated hospitals demonstrate unwavering commitment to advancing our understanding and treatment options for individuals affected by intracranial hypertension—a condition characterized by increased pressure inside the skull that can lead to debilitating symptoms such as severe headaches and visual disturbances. Through these collective efforts across various locations nationwide, we can gain valuable insights into potential interventions or therapies that may alleviate suffering and improve outcomes for patients living with this challenging neurological disorder. Each study conducted brings us closer to finding more effective solutions and offering hope for those impacted by this complex condition.
Which are the best cities for intracranial hypertension clinical trials?
When it comes to intracranial hypertension clinical trials, several cities are at the forefront of research. Miami, Florida leads with 3 active trials, investigating Study Phase 1 and Presendin among other treatments. Minneapolis, Minnesota also shows promise with 2 ongoing studies focused on Presendin and Video ophthalmoscope implementation. New york, New York follows closely behind with 2 active trials exploring Presendin and Venous sinus stenting (Serenity River). Additionally, Dallas, Texas contributes to the advancement of treatments through its 2 current trials centered around Presendin and Intensive Treatment. Lastly, Fort Sam Houston in Texas offers a single trial dedicated to prophylactic measures for intracranial hypertension treatment in its early stages. These cities serve as hubs for cutting-edge research that may improve outcomes for individuals affected by this condition.
Which are the top treatments for intracranial hypertension being explored in clinical trials?
Exciting developments are occurring in the realm of intracranial hypertension treatment, with several cutting-edge approaches currently being explored in clinical trials. These top treatments include Presendin, a novel therapy undergoing one active trial and marking its debut in 2022. The video ophthalmoscope is also garnering attention, participating in one ongoing trial since its first listing in 2019. Another promising contender is Study Arm, engaged in one active trial after making its initial appearance on the scene back in 2017. Additionally, venous sinus stenting (Serenity River) shows great potential with one active trial and has been part of the research landscape since 2018. As researchers delve further into these innovative treatments, new possibilities for managing intracranial hypertension may emerge to improve patient outcomes worldwide.
What are the most recent clinical trials for intracranial hypertension?
Recent clinical trials offer hope for those affected by intracranial hypertension, a condition characterized by increased pressure within the skull. One promising study focuses on Presendin, an investigational treatment currently in Phase 3. This trial aims to evaluate the safety and efficacy of Presendin for managing intracranial hypertension symptoms and improving patient outcomes. Another notable trial explores intensive treatment approaches specifically tailored to address this challenging condition during Phase 2 testing. With these advancements in research, there is optimism for improved management strategies and better quality of life for individuals living with intracranial hypertension.
What intracranial hypertension clinical trials were recently completed?
Recently completed clinical trials have made significant progress in the study of intracranial hypertension. Notably, a trial sponsored by Washington University School of Medicine was successfully concluded, shedding light on new potential treatments for this condition. The completion of these trials demonstrates the commitment and dedication of researchers to better understand and address intracranial hypertension, offering hope to patients affected by this challenging neurological disorder.