SGLT2 Inhibitor
Zibotentan + Dapagliflozin for Liver Cirrhosis
This trial is testing a combination of two drugs, zibotentan and dapagliflozin, and also dapagliflozin alone. It targets people with liver disease (cirrhosis) that causes high blood pressure in the liver's veins. The treatment aims to lower this high blood pressure and improve liver health. Dapagliflozin is a medication that has been shown to reduce cardiovascular death and heart failure.
Behavioural Intervention
Communication Intervention for Dementia
This trial is testing whether or not the Jumpstart intervention can improve patient-centered outcomes for those with chronic illness. The study will specifically look at Alzheimer's disease and related dementias, but will also include other common chronic illnesses. The trial will assess the efficacy of the intervention by measuring quality of care, intensity of care outcomes, and patient- and family-reported outcomes. There will also be a mixed-methods evaluation of the implementation of the intervention to explore barriers and facilitators to future implementation and dissemination.
Cholates for Liver Disease
This trial aims to improve the evaluation of patients with advanced liver disease. Currently, the assessment is limited to imaging, liver function tests, and liver biopsy. However, with advancements in treatments and liver transplantation
Procedure
TIPS Procedure for Liver Cirrhosis and Muscle Loss
This trial will test whether TIPS creation leads to improved muscle mass, body composition and muscle function within the first 12 months after the procedure compared to a control group without TIPS, and whether these changes improve liver disease outcomes in patients awaiting liver transplantation.
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Trials for Hepatocellular Carcinoma Patients
Procedure
Histotripsy with HistoSonics System for Liver Cancer
This trial tests a device that uses sound waves to break down liver tumors. It targets patients with liver tumors that may not respond to other treatments. The device works by creating bubbles in the tumor, which then burst and destroy the tumor cells.
Procedure
Anticoagulant Flush for Abdominal Cancer
This trial is comparing the amount and quality of tissue obtained by endoscopic ultrasound-guided fine needle biopsy when the device is flushed with an anticoagulant or saline solution, as well as the use of a microsieve.
Virus Therapy
Viral Therapy for Liver Cancer
This trial is studying a new virus that has been genetically engineered to produce interferon beta, which may help to treat patients with liver cancer or other solid tumors that have spread to other parts of the body and are not responding to treatment.
Trials for Liver Cancer Patients
Procedure
Histotripsy with HistoSonics System for Liver Cancer
This trial tests a device that uses sound waves to break down liver tumors. It targets patients with liver tumors that may not respond to other treatments. The device works by creating bubbles in the tumor, which then burst and destroy the tumor cells.
Procedure
Anticoagulant Flush for Abdominal Cancer
This trial is comparing the amount and quality of tissue obtained by endoscopic ultrasound-guided fine needle biopsy when the device is flushed with an anticoagulant or saline solution, as well as the use of a microsieve.
Virus Therapy
Viral Therapy for Liver Cancer
This trial is studying a new virus that has been genetically engineered to produce interferon beta, which may help to treat patients with liver cancer or other solid tumors that have spread to other parts of the body and are not responding to treatment.
Phase 3 Trials
Statin
Simvastatin for Liver Cirrhosis
This trial tests if simvastatin can prevent serious liver problems in U.S. Veterans with early-stage liver damage. Simvastatin not only lowers cholesterol but also helps protect the liver from further damage and reduces the risk of severe liver issues. Statins, including simvastatin, have been increasingly recognized for their potential benefits in treating chronic liver diseases, including cirrhosis, by reducing portal pressure and protecting against liver damage.
Procedure
PCEA vs IV PCA for Postoperative Pain Management After Liver Surgery
This trial will compare patient-controlled epidural analgesia (PCEA) to the current standard of care, IV PCA, to see if PCEA is a better method for managing pain after liver resection.
Anti-fibrinolytic agent
TXA for Bleeding in Liver Surgery
This trial will evaluate the impact of tranexamic acid on perioperative blood transfusion in patients undergoing liver resection. TXA is given to help prevent or treat excessive bleeding. The study will enroll 1230 participants.
Procedure
Mobile Stroke Unit Management for Stroke
This trial will compare pre-hospital diagnosis and treatment of patients with stroke symptoms using a Mobile Stroke Unit (MSU) with subsequent transfer to a Comprehensive Stroke Center (CSC) Emergency Department (ED), to standard pre-hospital triage and transport by Emergency Medical Services (EMS) to a CSC ED.
Trials With No Placebo
Endothelin Receptor Antagonist
Zibotentan for Non-invasive Indices to Predict Hepatic Fibrosis in BA Patients.
"This trial aims to study how the body processes Zibotentan in healthy participants from different ethnic backgrounds, including non-Asian and Japanese individuals."
Procedure
Histotripsy with HistoSonics System for Liver Cancer
This trial tests a device that uses sound waves to break down liver tumors. It targets patients with liver tumors that may not respond to other treatments. The device works by creating bubbles in the tumor, which then burst and destroy the tumor cells.
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Frequently Asked Questions
Introduction to liver fibrosis
What are the top hospitals conducting liver fibrosis research?
In the battle against liver fibrosis, top hospitals across different parts of the United States are making significant strides through clinical trials. Located in Edinburg, Texas, the South Texas Research Institute is currently conducting three active trials focused on liver fibrosis. While they may have a smaller number of all-time trials at just three, their first recorded trial in 2020 demonstrates their commitment to exploring new treatments for this condition. Meanwhile, Massachusetts General Hospital in Boston has also dedicated its resources to liver fibrosis research with three ongoing trials and an impressive fifteen completed studies since their initial investigation back in 2000.
On the West Coast, the University of California San Francisco joins the ranks with three active clinical trials targeting liver fibrosis. Although they have conducted fewer all-time trials with a total of seven thus far, their trailblazing journey into understanding this disease began in 2013. Similarly, the University of Alabama at Birmingham is actively engaged in researching liver fibrosis through three ongoing clinical trials and five previously conducted studies since embarking on this path also in 2013.
Adding to these esteemed institutions' efforts is Hunter Holmes McGuire VA Medical Center situated in Richmond. This medical center boasts an extensive history when it comes to studying liver fibrosis; having commenced their first recorded trial as early as 2011 and accumulating an impressive nineteen all-time studies aimed at unraveling potential treatments for this condition.
These hospitals serve as beacons of hope for those affected by liver fibrosis, dedicating themselves to uncovering innovative therapies that can improve patients' lives. Through collaborative efforts nationwide within diverse locations such as Edinburg,Texas,Boston's Massachusetts General Hospital,and centers located from California's San Francisco Bay Area up until Birmingham or Virginia;a united front emerges towards achieving breakthroughs against Liver Fibriosis offering optimism not only for countless individuals directly impacted by this disease but also for shaping future medical advancements that could revolutionize patient care worldwide.
Which are the best cities for liver fibrosis clinical trials?
In the realm of liver fibrosis clinical trials, several cities emerge as prominent hubs for research and advancements. Seattle, Washington; New york, New York; Houston, Texas; Richmond, Virginia; and San Antonio, Texas are leading the way with a significant number of active trials focused on this condition. These trials explore various treatments such as belapectin, Fazirsiran, Atezolizumab, LPCN 1148, Resmetirom, Part B: Treatment Group 3 among others. With their extensive research initiatives and diverse range of investigative approaches to liver fibrosis treatment options these cities provide valuable opportunities for individuals seeking participation in cutting-edge clinical trials that could potentially shape future care strategies.
Which are the top treatments for liver fibrosis being explored in clinical trials?
Liver fibrosis, a serious condition with limited treatment options, is the focus of ongoing clinical trials exploring innovative approaches. One standout contender is prehabilitation, which has shown promise in two active liver fibrosis trials since its introduction in 2021. Another potential breakthrough is the Jumpstart Guide, currently being tested in one trial dedicated to liver fibrosis and first listed in 2023. With researchers diligently working towards new solutions, hope shines on the horizon for patients grappling with this challenging disease.
What are the most recent clinical trials for liver fibrosis?
Recent clinical trials for liver fibrosis offer promising prospects in the field of treatment. Intracavitary tocilizumab has emerged as a potential therapeutic approach, with phase 1 trials demonstrating its efficacy. Similarly, LY3885125 has shown promise in early-phase studies targeting liver fibrosis. Additionally, eHealth mindful movement and breathing group interventions have been explored to alleviate the impact of liver fibrosis on patients' well-being. The advancements made through these clinical trials bring hope to individuals affected by this condition, offering new possibilities for improved care and management strategies in the near future.
What liver fibrosis clinical trials were recently completed?
Several clinical trials focusing on liver fibrosis have recently achieved completion, marking significant progress in the search for effective treatments. In November 2021, Stanford University successfully concluded a trial investigating Empagliflozin 10 MG's potential to address this condition. Similarly, the University of Michigan completed a trial examining the effectiveness of Lactulose during the same month. Back in March 2021, Georgetown University finalized their study evaluating Proglumide's impact on liver fibrosis. These recent developments underscore researchers' commitment to combatting liver fibrosis and offer hope for patients grappling with this challenging condition.