Popular Trials
Procedure
Live Donor Liver Transplantation for Colorectal Cancer Liver Metastases
This trial will offer live donor liver transplantation to select patients with unresectable metastases that are 1) limited to the liver and 2) stable (non-progressing) on standard chemotherapy.
Procedure
Liver Transplant for Bile Duct Cancer
This trial is for patients with intrahepatic cholangiocarcinoma who have achieved 6 months of disease stability while receiving standard chemotherapy. If eligible, they will be listed for transplantation. After transplantation, they will be followed for disease recurrence and overall survival.
Behavioral Intervention
Integrated AUD Treatment for Alcoholic Hepatitis
This trial will examine the effects of integrated, person- and computer-delivered alcohol treatment compared to standard care on alcohol use, mood, quality of life and survival following AH-LT.
Popular Filters
Trials for Liver Cirrhosis Patients
Procedure
TIPS Procedure for Liver Cirrhosis and Muscle Loss
This trial will test whether TIPS creation leads to improved muscle mass, body composition and muscle function within the first 12 months after the procedure compared to a control group without TIPS, and whether these changes improve liver disease outcomes in patients awaiting liver transplantation.
Behavioral Intervention
LIFT + REAP for Frailty in Liver Transplant Candidates
This trial will test a new intervention to improve frailty in patients awaiting liver transplant. The intervention includes an evaluation by a physical therapist, an individualized home exercise prescription, and exercise tracking using a smart phone application. The investigators also aim to perform "Realistic Effort Action Planning" in a subset of patients to determine if this enhances the intervention.
Behavioral Intervention
TEST Intervention for Liver Transplant Adherence
This trial will study how available technology combined with transplant center resources and caregiver support can optimize medication adherence, quality of life, and health outcomes among new liver transplant recipients at 3 centers.
Trials for Liver Cancer Patients
Monoclonal Antibodies
Atezolizumab + Bevacizumab for Liver Cancer
This trial will test whether a combination of two drugs can help treat liver cancer in patients who are eligible for transplantation. The drugs will be given for six months before the transplant procedure.
Trials With No Placebo
Immunosuppressant
Prograf vs Envarsus for Liver Transplant Patients
"This trial compares two different forms of a medication called Tacrolimus used to prevent organ rejection in liver transplant patients. The study will look at how Prograf and Envarsus affect liver and kidney function
Behavioral Intervention
mHealth Messaging for Transplant Medication Adherence
"This trial aims to see if a mobile technology intervention can help young people who have had kidney or liver transplants to remember to take their medication on time. The intervention includes an electronic pillbox and text
Procedure
TIPS Procedure for Liver Cirrhosis and Muscle Loss
This trial will test whether TIPS creation leads to improved muscle mass, body composition and muscle function within the first 12 months after the procedure compared to a control group without TIPS, and whether these changes improve liver disease outcomes in patients awaiting liver transplantation.
Cell Therapy
Cellular Therapy for Liver Transplant Recipients
This trial is testing a treatment using special cells to help liver transplant patients stop taking anti-rejection drugs. It targets liver transplant recipients and aims to help their immune systems accept the new liver naturally. Recent studies have shown benefits of combining these special cells with minimal medication to promote acceptance and potentially regeneration.
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Frequently Asked Questions
Introduction to liver transplant
What are the top hospitals conducting liver transplant research?
When it comes to cutting-edge clinical trials in liver transplantation, several prestigious hospitals are leading the way. In Toronto, the University Health Network is at the forefront with five ongoing liver transplant trials. This renowned institution is dedicated to advancing the field of liver transplantation and improving patient outcomes through rigorous research. In Chicago, Northwestern University is making significant strides as well, currently conducting four active trials focused on liver transplants. With a commitment to innovation and excellence in healthcare, this hospital aims to revolutionize the field of liver transplantation. Similarly, the University of Pennsylvania in Philadelphia has also invested in four active clinical trials for liver transplants, demonstrating their dedication to finding new solutions for patients awaiting life-saving procedures.
Furthermore,Toronto General Hospital shares its commitment by participating in three ongoing clinical trials for liver transplantations while continuing its legacy of providing state-of-the-art medical care.These collective efforts ensure that patients facing critical challenges have access to pioneering treatments and potential breakthroughs.
On the other side of North America,in San Francisco,the University of California presents itself as an invaluable contributor where researchers actively engage incarrying outthree distinctlivertransplanttrials;their devotion towards exploring innovative approaches manifests their unwavering dedication towards transforming lives through these groundbreaking studies.
These top-tier institutions serve not only as pillars within their respective communities but also exemplify how collaboration between medical professionals can lead to transformative advancements in organ transplantation.The expansive groundwork laid by such hospitals paves a path toward improved techniques,survival rates,and overall qualityof lifefor individuals suffering from end-stage liver disease.Every step taken towards enhancing our understanding and refining treatment options provides hope for individuals awaiting life-altering transplants—ultimately changing countless lives forever
Which are the best cities for liver transplant clinical trials?
When it comes to liver transplant clinical trials, several cities emerge as top contenders in advancing research and treatment options. New york, with 11 active trials, focuses on studies such as HIVD+/R+, Telemetric Intervention, and the VitaSmart Liver Machine Perfusion System. Chicago follows closely behind with 10 ongoing trials exploring interventions like "Liver FrailTy" intervention (LIFT) among others. Toronto also plays a significant role with its 9 active trials investigating live donor liver transplantation, PET MRI, and Deceased donor Liver Transplantation. These cities showcase remarkable dedication to pushing the boundaries of liver transplant research and offering hope for patients in need of this life-saving procedure.
Which are the top treatments for liver transplant being explored in clinical trials?
Clinical trials for liver transplant treatments are yielding promising results, with several notable contenders taking the spotlight. One of the leading options is Apabetalone, which has shown potential in improving outcomes after liver transplantation. Another noteworthy treatment being explored is FT-4202, which aims to address complications related to sickle cell disease post-transplantation. Additionally, the drug Maralixibat is under investigation for its potential benefits in preventing bile acid-related complications following a liver transplant. With ongoing research and advancements, these treatments offer hope for enhancing patient outcomes in liver transplantation procedures.
What are the most recent clinical trials for liver transplant?
Exciting progress is being made in the field of liver transplant, with recent clinical trials exploring new possibilities and potential treatments. One such trial investigates the use of semaglutide pen injector, currently in Phase 2. This innovative approach aims to improve outcomes for liver transplant patients. Another study focuses on combining atezolizumab and bevacizumab in a Phase 4 trial, seeking to optimize immunosuppressive strategies for successful liver transplantation. Additionally, fenofibrate has shown promise as a treatment option through its ongoing Phase 2 trial. As researchers continue their efforts to enhance patient care, these advancements offer hope for individuals undergoing or awaiting a liver transplant procedure.
What liver transplant clinical trials were recently completed?
Recently completed clinical trials in the field of liver transplantation have yielded important findings, bringing hope to patients awaiting this life-saving procedure.