Popular Trials
BTK Inhibitor
Ibrutinib + Pembrolizumab for Leukemia and Lymphoma
This trial will help determine the best dose of ibrutinib in combination with pembrolizumab for patients with CLL or MCL that has relapsed or progressed after prior therapy. The safety of this combination will also be studied.
Radiation Therapy
Orbital Radiation Therapy for Lymphoma
This trial is studying ultra low dose orbital radiation therapy to treat stage I-IV low grade B-cell lymphoma or mantle cell lymphoma involving the orbit of the eye. This type of radiation therapy uses external beam radiation to destroy cancer cells and may be effective with fewer side effects.
Bruton's Tyrosine Kinase (BTK) Inhibitor
Ibrutinib + Lenalidomide + Rituximab for Lymphoma
This trial tests a combination of three drugs (ibrutinib, lenalidomide, and rituximab) in patients with mantle cell lymphoma who have not responded to other treatments. Ibrutinib stops cancer cell growth, lenalidomide boosts the immune system, and rituximab helps the immune system target cancer cells. Lenalidomide and rituximab have shown significant activity in mantle cell lymphoma, both as monotherapies and in combination. The goal is to find the best dose and see how well this combination works.
Bruton's Tyrosine Kinase (BTK) Inhibitor
Acalabrutinib for Mantle Cell Lymphoma
This trial will help researchers learn more about how safe and effective ACP-196 is for treating people with a certain type of cancer that has come back or does not respond to other treatments.
Popular Filters
Trials for MCL Patients
LOXO-338 for Blood Cancers
This trial is testing a new drug, LOXO-338, to treat advanced blood cancer in patients who haven't responded to standard treatments. If effective alone, it will also be tested with another drug, pirtobrutinib, to see if the combination works better.
CDK4/6 Inhibitor
Palbociclib + Ibrutinib for Mantle Cell Lymphoma
This trial tests a combination of two drugs, palbociclib and ibrutinib, for patients with mantle cell lymphoma who have previously received treatment. Palbociclib stops cancer cells from dividing, while ibrutinib blocks signals that help cancer cells grow. The goal is to see how well this combination works in slowing down or stopping the cancer.
Kinase Inhibitor
Ibrutinib + Rituximab for Mantle Cell Lymphoma
This trial is testing ibrutinib and rituximab as a treatment for mantle cell lymphoma. Ibrutinib may stop the growth of cancer cells by blocking enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, may find cancer cells and help kill them.
Aurora Kinase Inhibitor
Triple Therapy for Lymphoma
This trial is testing the side effects and best dose of two drugs, alisertib and bortezomib, when given together with rituximab to treat patients with mantle cell lymphoma or B-cell low grade non-Hodgkin lymphoma that has returned after a period of improvement (relapsed) or does not respond to treatment (refractory).
Trials for Lymphoma Patients
LOXO-338 for Blood Cancers
This trial is testing a new drug, LOXO-338, to treat advanced blood cancer in patients who haven't responded to standard treatments. If effective alone, it will also be tested with another drug, pirtobrutinib, to see if the combination works better.
Monoclonal Antibodies
Combination Therapy for Mantle Cell Lymphoma
This trial is studying a combination of rituximab, bortezomib, bendamustine, and lenalidomide to see how well it works compared with rituximab and bendamustine, followed by rituximab alone or with lenalidomide, in treating mantle cell lymphoma.
Bruton's Tyrosine Kinase (BTK) Inhibitor
Zanubrutinib + Rituximab vs Bendamustine + Rituximab for Mantle Cell Lymphoma
This trial will compare two treatments for mantle cell lymphoma in people who are not eligible for stem cell transplantation. One treatment is zanubrutinib plus rituximab, and the other is bendamustine plus rituximab. The trial will compare how well each treatment works and how safe each is.
Histone Deacetylase Inhibitor
Abexinostat + Ibrutinib for Lymphoma
This trial tests if combining abexinostat and ibrutinib can safely stop cancer growth in patients by blocking enzymes and proteins that help cancer cells grow and survive. Ibrutinib is a medication approved for treating various cancers.
Trials for CCND1 Positive Patients
CDK4/6 Inhibitor
Palbociclib + Ibrutinib for Mantle Cell Lymphoma
This trial tests a combination of two drugs, palbociclib and ibrutinib, for patients with mantle cell lymphoma who have previously received treatment. Palbociclib stops cancer cells from dividing, while ibrutinib blocks signals that help cancer cells grow. The goal is to see how well this combination works in slowing down or stopping the cancer.
Kinase Inhibitor
Ibrutinib + Rituximab for Mantle Cell Lymphoma
This trial is testing ibrutinib and rituximab as a treatment for mantle cell lymphoma. Ibrutinib may stop the growth of cancer cells by blocking enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, may find cancer cells and help kill them.
Monoclonal Antibodies
Combination Therapy for Mantle Cell Lymphoma
This trial is studying a combination of rituximab, bortezomib, bendamustine, and lenalidomide to see how well it works compared with rituximab and bendamustine, followed by rituximab alone or with lenalidomide, in treating mantle cell lymphoma.
Bruton's Tyrosine Kinase Inhibitor
Ibrutinib for Mantle Cell Lymphoma
This trial will study how well ibrutinib works in treating people with untreated high risk smoldering mental cell lymphoma. Ibrutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Trials for CD20 Positive Patients
Kinase Inhibitor
Ibrutinib + Rituximab for Mantle Cell Lymphoma
This trial is testing ibrutinib and rituximab as a treatment for mantle cell lymphoma. Ibrutinib may stop the growth of cancer cells by blocking enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, may find cancer cells and help kill them.
Bruton's Tyrosine Kinase Inhibitor
Ibrutinib for Mantle Cell Lymphoma
This trial will study how well ibrutinib works in treating people with untreated high risk smoldering mental cell lymphoma. Ibrutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Phase 3 Trials
Bruton's Tyrosine Kinase (BTK) Inhibitor
Zanubrutinib + Rituximab vs Bendamustine + Rituximab for Mantle Cell Lymphoma
This trial will compare two treatments for mantle cell lymphoma in people who are not eligible for stem cell transplantation. One treatment is zanubrutinib plus rituximab, and the other is bendamustine plus rituximab. The trial will compare how well each treatment works and how safe each is.
Kinase Inhibitor
Long-term Ibrutinib for Lymphoma
This trial aims to provide ongoing access to ibrutinib for patients who have benefited from it in previous studies. Ibrutinib is an oral medication that blocks a protein involved in cancer growth, helping to slow or stop the disease. The study will monitor safety and effectiveness over time. Ibrutinib has been studied extensively and is used to treat various B cell malignancies, including chronic lymphocytic leukemia and mantle cell lymphoma.
Trials With No Placebo
LOXO-338 for Blood Cancers
This trial is testing a new drug, LOXO-338, to treat advanced blood cancer in patients who haven't responded to standard treatments. If effective alone, it will also be tested with another drug, pirtobrutinib, to see if the combination works better.
CDK4/6 Inhibitor
Palbociclib + Ibrutinib for Mantle Cell Lymphoma
This trial tests a combination of two drugs, palbociclib and ibrutinib, for patients with mantle cell lymphoma who have previously received treatment. Palbociclib stops cancer cells from dividing, while ibrutinib blocks signals that help cancer cells grow. The goal is to see how well this combination works in slowing down or stopping the cancer.
Kinase Inhibitor
Ibrutinib + Rituximab for Mantle Cell Lymphoma
This trial is testing ibrutinib and rituximab as a treatment for mantle cell lymphoma. Ibrutinib may stop the growth of cancer cells by blocking enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, may find cancer cells and help kill them.
View More Related Trials
Frequently Asked Questions
Introduction to mantle cell lymphoma
What are the top hospitals conducting mantle cell lymphoma research?
When it comes to advancing treatment options for mantle cell lymphoma, several top hospitals are leading the way. One such institution is the renowned M D Anderson Cancer Center in Houston, which currently has an impressive 13 active clinical trials focused on this form of lymphoma. With a history that dates back to their first recorded trial in 1998, they have accumulated a total of 33 trials dedicated specifically to mantle cell lymphoma over time. Meanwhile, at Memorial Sloan Kettering Cancer Center in New york City, experts are actively conducting five trials for this disease and have completed a remarkable 25 previous studies since initiating their first trial in 2003.
In Duarte's City of Hope Medical Center, researchers are also making significant strides with five ongoing clinical trials for mantle cell lymphoma and an extensive track record of 22 conducted studies since their initial investigation began in 1997. Similarly contributing to the field is the Washington University School of Medicine located in Saint Louis where they presently have five active clinical tests while having previously contributed towards sixteen investigations from starting their inaugural research on mantle cell lymphoma as late as2005.The Mayo Clinic located in Rochester may also be considered smaller-scale compared to some others but still plays an important role by actively participating with four current mantle cell lymphoma clinical trials complemented by twenty-six accomplished experiments; theirs can be traced back only seventeen years ago untilfirst study was initiatedin2004.
These prominent hospitals serve as pillars within the medical community when it comes to advancing our understanding and treatment options for mantle cell lymphoma. Their ongoing dedication exemplifies how collaboration between top institutions brings us closer to finding effective therapies that can improve the lives of individuals affected by this condition worldwide
Which are the best cities for mantle cell lymphoma clinical trials?
When it comes to mantle cell lymphoma clinical trials, several cities emerge as key hubs for research and treatment. Houston, Texas takes the lead with 29 active trials investigating Acalabrutinib, Lenalidomide, Pirtobrutinib, and other potential therapies. Denver, Colorado closely follows with 25 ongoing studies focused on rituximab, Autologous Hematopoietic Stem Cell Transplantation, Lenalidomide, and more. Anchorage, Alaska also shows promise with 21 active trials exploring Cytarabine, Autologous Hematopoietic Stem Cell Transplantation, rituximab among others. While New york City offers 17 active trials examining Ibrutinib, Rituximab Venetoclax alongside other interventions. Lastly Atlanta rounds up the list with 13 ongoing studies delving into treatments such as Cytarabine Autologous Hematopoietic Stem Cell Transplantation and Rituximab among others. These cities provide patients battling mantle cell lymphoma access to a range of cutting-edge clinical trials that contribute towards advancements in care and improved outcomes.
Which are the top treatments for mantle cell lymphoma being explored in clinical trials?
Exciting developments are underway in clinical trials for mantle cell lymphoma, with several top treatments making waves. Leading the charge is rituximab, a formidable contender currently being explored in eight active trials and boasting an impressive record of 84 all-time clinical trials since its first listing back in 2001. Close behind is acalabrutinib, gaining momentum with six ongoing studies and 21 all-time trials dedicated to tackling this challenging disease since its introduction in 2015. Also vying for attention is the veteran drug ibrutinib, engaging in four active trials and accumulating a noteworthy portfolio of 48 all-time mantle cell lymphoma studies following its debut in 2012. Not far behind are venetoclax and pirtobrutinib—both demonstrating promise through their respective involvement in four and two active trials focused on advancing treatment options for patients battling this form of lymphoma. These remarkable advancements offer hope as researchers strive to unlock new breakthroughs against mantle cell lymphoma.
What are the most recent clinical trials for mantle cell lymphoma?
Exciting progress is being made in the realm of mantle cell lymphoma with recent clinical trials offering promising treatment avenues. One such trial explores a combination therapy involving venetoclax, glofitamab, and lenalidomide for patients with mantle cell lymphoma. Another study focuses on acalabrutinib in conjunction with venetoclax and rituximab as a potential treatment approach. Additionally, pirtobrutinib shows encouraging results as it undergoes evaluation for its efficacy against mantle cell lymphoma. These ongoing Phase 2 trials bring hope to individuals battling this challenging disease, while researchers continue their tireless efforts to improve outcomes and enhance patient care.
What mantle cell lymphoma clinical trials were recently completed?
Recent clinical trials for mantle cell lymphoma have made significant strides in advancing treatment options for this challenging disease. Among the completed trials, TCR2 Therapeutics conducted a trial on TC-110 T Cells that concluded in March 2020. Memorial Sloan Kettering Cancer Center successfully completed a trial testing Copanlisib in March 2019, while Prelude Therapeutics wrapped up their PRT543 study in February of the same year. These important milestones highlight the ongoing commitment of researchers and offer hope to patients affected by mantle cell lymphoma.