Popular Trials
Alkylating agents
Chemoradiotherapy + Stem Cell Transplant for Blood Cancers
This trial is giving chemotherapy drugs and HT before a donor stem cell transplant to see if it helps stop the growth of cancer cells and also helps stop the patient's immune system from rejecting the donor's stem cells.
Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor
JNJ-64619178 for Cancer
This trial is testing a new cancer drug to see what doses are tolerated by patients with different types of cancer, including lymphoma and solid tumors. The goal is to also find out what doses of the drug might be effective in treating these cancers.
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Trials for MDS Patients
Alkylating agents
Cord Blood Transplant for Blood Diseases
This trial uses stem cells from a baby's umbilical cord to treat patients who need new healthy stem cells. Patients first get strong medicine to clear out unhealthy cells, then receive the new stem cells, and take medications to prevent complications. Umbilical cord blood has been used in the treatment of various diseases, including leukemias, lymphomas, and immune system disorders.
IDH1 Inhibitor
AG-120 for Blood Cancers
This trial is testing a new drug, AG-120, to see if it's safe and effective in treating people with advanced cancers that have a mutation in the IDH1 gene. The trial has two parts: first, they'll test different doses of the drug to see what the maximum tolerated dose is; then, they'll expand the trial to a larger group of people to see if the drug is effective. There's also a substudy testing AG-120 in people with a different but related cancer, myelodysplastic syndrome.
Trials for Myelomonocytic Leukemia Patients
Alkylating agents
Cord Blood Transplant for Blood Diseases
This trial uses stem cells from a baby's umbilical cord to treat patients who need new healthy stem cells. Patients first get strong medicine to clear out unhealthy cells, then receive the new stem cells, and take medications to prevent complications. Umbilical cord blood has been used in the treatment of various diseases, including leukemias, lymphomas, and immune system disorders.
IDH1 Inhibitor
AG-120 for Blood Cancers
This trial is testing a new drug, AG-120, to see if it's safe and effective in treating people with advanced cancers that have a mutation in the IDH1 gene. The trial has two parts: first, they'll test different doses of the drug to see what the maximum tolerated dose is; then, they'll expand the trial to a larger group of people to see if the drug is effective. There's also a substudy testing AG-120 in people with a different but related cancer, myelodysplastic syndrome.
Trials for HLA-A Positive Patients
CAR T-cell Therapy
Gene Modified T-cells for Blood Disorders
This trial will look at whether T cells from a family member can help a patient's immune system recover after a stem cell transplant, with the added safety measure of a self-destruct switch.
Alkylating agents
Bone Marrow Transplant for Blood Cancers
This trial tests a stem cell transplant for patients who need a transplant but don't have a perfect match. The process uses a less intense preparation method and aims to see if patients remain disease-free over time.
Chemotherapy
Treg-Enriched Stem Cell Transplant for Leukemia
This trial is studying a new way to give a haploidentical stem cell transplant (using donor cells that have been enriched with regulatory T cells) to people with relapsed or refractory acute myeloid leukemia or myelodysplastic syndrome.
Procedure
Experimental Drug for Leukemia Post-Stem Cell Transplant
This trial is testing two different doses of an experimental drug to see if it is safe and effective in treating patients with leukemia who have received a stem cell transplant from a related donor.
Phase 3 Trials
Protein Therapeutics
Luspatercept vs Epoetin Alfa for MDS-related Anemia
This trial will compare luspatercept to epoetin alfa to see if luspatercept is more effective in increasing hemoglobin and reducing the need for RBC transfusions in patients with anemia due to MDS.
Anti-metabolites
Cedazuridine + Azacitidine for Leukemia
This trial tests a new pill form of two drugs, cedazuridine and azacitidine, for patients needing azacitidine treatment. The goal is to see if the pill is as effective as the injection. Cedazuridine helps azacitidine work better by preventing its breakdown, and azacitidine stops cancer cells from growing.
Cancer Treatment
Epoetin Alfa vs Luspatercept for Myelodysplastic Syndrome
This trial is testing two treatments, Luspatercept and epoetin alfa, to see which is better for treating anemia in adults with certain types of myelodysplastic syndromes (MDS). The participants have not used similar treatments before and do not need regular blood transfusions. Luspatercept helps red blood cells mature, while epoetin alfa increases their production.
Trials With No Placebo
Alkylating agents
Cord Blood Transplant for Blood Diseases
This trial uses stem cells from a baby's umbilical cord to treat patients who need new healthy stem cells. Patients first get strong medicine to clear out unhealthy cells, then receive the new stem cells, and take medications to prevent complications. Umbilical cord blood has been used in the treatment of various diseases, including leukemias, lymphomas, and immune system disorders.
IDH1 Inhibitor
AG-120 for Blood Cancers
This trial is testing a new drug, AG-120, to see if it's safe and effective in treating people with advanced cancers that have a mutation in the IDH1 gene. The trial has two parts: first, they'll test different doses of the drug to see what the maximum tolerated dose is; then, they'll expand the trial to a larger group of people to see if the drug is effective. There's also a substudy testing AG-120 in people with a different but related cancer, myelodysplastic syndrome.
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Frequently Asked Questions
Introduction to mds
What are the top hospitals conducting mds research?
When it comes to cutting-edge clinical trials in the field of myelodysplastic syndromes (MDS), several top hospitals are making significant strides. In Boston, the Dana Farber Cancer Institute leads the way with an impressive 13 active MDS trials and a commendable history of 42 completed studies since their first recorded trial in 2001. Another institution contributing to advancements in MDS research is Massachusetts General Hospital, also located in Boston. They currently have seven ongoing MDS trials and have conducted a remarkable total of 47 trials dating back to their earliest recorded trial in 1984.
Moving southwards to Miami, we find the University of Miami playing an important role by conducting seven active clinical trials for MDS while accumulating experience from sixteen previously held investigations since initiating their first trial on this condition just fifteen years ago, in 2006.
Meanwhile, Washington University School of Medicine takes center stage as one of the leading institutions researching MDS. With six current clinical trials focused on this condition and a robust track record consisting of forty-one completed studies since they started recording data for these types of cases around eighteen years ago(way back till2003).
Finally rounding out our list is Fred Hutchinson Cancer Research Center situated amidst Seattle's vibrant medical community; despite a smaller number compared to other establishments mentioned so far still undeniably contribute significantly towards understanding Myelodysplastic Syndromes better.With six ongoing clinical tests under its belt combined with eighty-five previous experiments spanning three decades(making them one among most experienced) marking pivotal starting point exactly thirty years ago during1991
These esteemed hospitals represent beacons of hope for those affected by MDS worldwide. Through groundbreaking research and innovative approaches, each step taken brings us closer to more effective treatments and improved outcomes for patients living with this complex blood disorder.
Which are the best cities for mds clinical trials?
When it comes to MDS (myelodysplastic syndromes) clinical trials, several cities emerge as leading hubs for research and innovation. Among them are Boston, Massachusetts, with 36 active trials investigating treatments like H3B-8800 (RVT-2001), Venetoclax, and Inqovi. Houston, Texas follows closely behind with 27 ongoing studies exploring therapies such as BGB-11417 and CC-95251. New york, New York is also a prominent city for MDS clinical trials with 20 active studies focusing on interventions like Bone Marrow Hematopoietic Stem Cell Transplantation and Oral Azacitidine. These cities offer individuals battling MDS the opportunity to participate in cutting-edge trials that may pave the way for improved treatment options and better outcomes.
Which are the top treatments for mds being explored in clinical trials?
Exciting advancements are taking place in the realm of MDS treatment, with several leading contenders emerging from ongoing clinical trials. One such contender is CPX-351, currently being explored in two active trials for MDS. Since its introduction in 2009, it has been involved in a total of 11 trials aiming to combat this condition. Another promising option on the horizon is luspatercept, which also boasts two active trials and has participated in a total of 15 MDS studies since its listing in 2016. Additionally, MBG453 and Atorvastatin show great potential as they both are engaged in two ongoing MDS trials each. As researchers delve deeper into these treatments' effectiveness and safety profiles, hope continues to grow for patients battling MDS worldwide
What are the most recent clinical trials for mds?
Recent clinical trials for MDS offer promising prospects in the field of hematologic disorders. Sitagliptin, Bortezomib, and Cyclophosphamide have demonstrated potential as a combined therapy for MDS patients. Another trial explores CD34+ Peripheral Blood Progenitor Cell Transplantation using Busulfan/Melphalan/Fludarabine regimen to improve outcomes in MDS cases. Itacitinib is also being investigated as a potential treatment option for this condition. Additionally, the use of Cy/Flu/TBI along with post-transplant CY shows promise in addressing MDS-related challenges. These ongoing trials shed light on new possibilities that may enhance the lives of individuals affected by MDS.
What mds clinical trials were recently completed?
In recent years, several clinical trials exploring potential treatments for MDS (myelodysplastic syndromes) have concluded, showcasing advancements in this field. Noteworthy completed trials include the investigation of Lemzoparlimab by AbbVie in June 2021, the evaluation of sabatolimab by Novartis Pharmaceuticals in May 2021, and a study on Azacitidine sponsored by Pfizer that also concluded in May 2021. These milestones highlight the ongoing efforts to find effective therapies for MDS and provide hope for patients affected by this condition.