Alkylating agents
Surgery + Chemotherapy + IMRT for Mesothelioma
This trial is testing a new, safer radiation therapy for people with a certain type of lung cancer. The old radiation therapy had lots of side effects, but the new one specifically targets the cancer and reduces the risk of damaging healthy tissue.
Chemotherapy
INCB099280 for Cancer
This trial is testing a new drug called INCB099280 to see if it is safe and effective for patients with certain types of solid tumors. Researchers want to understand how the drug behaves in the body and its early effects on cancer.
CAR T-cell Therapy
TIL Therapy for Advanced Cancer
This trial tests a treatment for advanced cancers that haven't responded to standard treatments. It involves reducing the patient's immune cells, then using their own enhanced immune cells to fight the cancer, supported by a drug that boosts immune activity.
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Trials for Adenocarcinoma Patients
Alkylating agents
Lurbinectedin + Irinotecan for Cancer
This trial is testing a new cancer drug, Lurbinectedin, in combination with another cancer drug, irinotecan. The trial will have two parts: first, they will test different doses of the drugs to see what is safe; then, they will expand the trial to include more people.
CAR T-cell Therapy
Engineered T Cells + Pembrolizumab for Pleural Cancer
This trial is testing the safety of different doses of modified T cells for patients with malignant pleural disease. They will also test the combination of the T cells with another drug, pembrolizumab, to see what effect it has on the cancer.
Monoclonal Antibodies
NGM831 + Pembrolizumab for Cancer
This trial is testing a new drug called NGM831 alone or with other drugs in patients with advanced or spreading solid tumors. The goal is to see if these treatments can help stop the cancer or help the immune system fight it better. One of the drugs being tested has been widely studied and used in various cancers, showing significant improvements in survival rates and being effective in combination with other treatments.
Chemotherapy
TAK-500 + Pembrolizumab for Advanced Solid Cancers
This trial is testing a new drug called TAK-500, alone or with pembrolizumab, in adults with advanced or spreading solid tumors. The goal is to see if TAK-500 is safe and effective in shrinking these tumors.
Monoclonal Antibodies
NGM707 + Pembrolizumab for Cancer
This trial is testing a new drug called NGM707, both by itself and with another drug, Pembrolizumab. It targets patients with very advanced or spreading solid tumors. The treatment aims to boost the immune system to better fight cancer.
Trials for NSCLC Patients
CAR T-cell Therapy
Cell Therapy for Mesothelioma
This trial is testing a new cell therapy that consists of T cells that have been genetically engineered to express a single-domain antibody that recognizes human Mesothelin. The T cells are fused to the CD3-epsilon subunit, which is incorporated into the endogenous T cell receptor (TCR) complex. The aim of the trial is to establish the recommended Phase 2 dose and to evaluate the efficacy of the therapy in patients with advanced mesothelin-expressing cancers.
CAR T-cell Therapy
Engineered T Cells + Pembrolizumab for Pleural Cancer
This trial is testing the safety of different doses of modified T cells for patients with malignant pleural disease. They will also test the combination of the T cells with another drug, pembrolizumab, to see what effect it has on the cancer.
Monoclonal Antibodies
NGM831 + Pembrolizumab for Cancer
This trial is testing a new drug called NGM831 alone or with other drugs in patients with advanced or spreading solid tumors. The goal is to see if these treatments can help stop the cancer or help the immune system fight it better. One of the drugs being tested has been widely studied and used in various cancers, showing significant improvements in survival rates and being effective in combination with other treatments.
Trials for Metastatic Patients
CAR T-cell Therapy
Cell Therapy for Mesothelioma
This trial is testing a new cell therapy that consists of T cells that have been genetically engineered to express a single-domain antibody that recognizes human Mesothelin. The T cells are fused to the CD3-epsilon subunit, which is incorporated into the endogenous T cell receptor (TCR) complex. The aim of the trial is to establish the recommended Phase 2 dose and to evaluate the efficacy of the therapy in patients with advanced mesothelin-expressing cancers.
CAR T-cell Therapy
Engineered T Cells + Pembrolizumab for Pleural Cancer
This trial is testing the safety of different doses of modified T cells for patients with malignant pleural disease. They will also test the combination of the T cells with another drug, pembrolizumab, to see what effect it has on the cancer.
Monoclonal Antibodies
NGM831 + Pembrolizumab for Cancer
This trial is testing a new drug called NGM831 alone or with other drugs in patients with advanced or spreading solid tumors. The goal is to see if these treatments can help stop the cancer or help the immune system fight it better. One of the drugs being tested has been widely studied and used in various cancers, showing significant improvements in survival rates and being effective in combination with other treatments.
Chemotherapy
TAK-500 + Pembrolizumab for Advanced Solid Cancers
This trial is testing a new drug called TAK-500, alone or with pembrolizumab, in adults with advanced or spreading solid tumors. The goal is to see if TAK-500 is safe and effective in shrinking these tumors.
Trials With No Placebo
CAR T-cell Therapy
Cell Therapy for Mesothelioma
This trial is testing a new cell therapy that consists of T cells that have been genetically engineered to express a single-domain antibody that recognizes human Mesothelin. The T cells are fused to the CD3-epsilon subunit, which is incorporated into the endogenous T cell receptor (TCR) complex. The aim of the trial is to establish the recommended Phase 2 dose and to evaluate the efficacy of the therapy in patients with advanced mesothelin-expressing cancers.
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Frequently Asked Questions
Introduction to mesothelioma
What are the top hospitals conducting mesothelioma research?
When it comes to advancing treatment options for mesothelioma, certain hospitals have emerged as leaders in clinical trials. Memorial Sloan Kettering Cancer Center in New york has taken the lead with ten ongoing trials and a total of 25 trials dedicated to this rare cancer. Their first recorded mesothelioma trial dates back to 2006, showcasing their commitment to pushing boundaries in research. Meanwhile, Massachusetts General Hospital in Boston has been making notable strides with eight active trials and a history of 17 completed studies since initiating their first mesothelioma trial in 2004.
Heading south to Houston, MD Anderson Cancer Center stands out with seven active clinical trials focused on mesothelioma and a cumulative total of 14 trials conducted thus far. They began their journey into researching this challenging condition in 2007. Similarly, Dana Farber Cancer Institute shares the spotlight with seven ongoing mesothelioma trials and an impressive record of 13 previously conducted studies since launching their inaugural trial in 2009.
Lastly but certainly not least is Mayo Clinic located in Rochester which also shoulders responsibility by conducting seven concurrent clinical tests for patients living with mesothelioma while contributing towards eleven prior investigations; they embarked on this journey just six years ago from2015.Mesothelioma presents its unique challenges due to its rarity and aggressive nature; however, these top-tier hospitals are forging ahead through innovative research efforts aimed at improving outcomes for those affected by this deadly disease.
Through collaboration between medical professionals across different locations and specialties, advancements are being made every day that bring us closer to finding more effective treatments or even potential cures for mesothelioma. The dedication displayed by these leading institutions highlights our collective determination to combat this challenging cancer head-on
Which are the best cities for mesothelioma clinical trials?
When it comes to mesothelioma clinical trials, several cities stand out as major hubs for research and treatment. New york City leads the way with 39 active trials investigating treatments like INBRX-109, ASTX295, and gavo-cel. Houston, Texas is also a prominent location with 37 ongoing studies focused on interventions such as Intensity-Modulated Radiation Therapy and NGM831. Boston, Massachusetts follows closely behind with 35 active trials exploring therapies like pembrolizumab and Lurbinectedin. Lastly, Los Angeles in California and Las Vegas in Nevada each offer 28 clinical trials examining various treatment approaches for mesothelioma patients. These cities provide individuals diagnosed with mesothelioma access to cutting-edge clinical trials that aim to improve outcomes and bring hope for better quality of life.
Which are the top treatments for mesothelioma being explored in clinical trials?
Mesothelioma, a challenging cancer to treat, is witnessing advancements in clinical trials as researchers explore potential breakthrough treatments. Leading the pack is pembrolizumab, with five active trials and an impressive 26 all-time mesothelioma trials since its introduction in 2015. Another contender making waves is LMB-100, which has shown promise with two ongoing trials and six total mesothelioma studies since its listing in 2016. Additionally, a pharmacological study has sparked interest with two active and three all-time mesothelioma trials recorded thus far. These innovative therapies offer hope for improved outcomes for patients battling this relentless disease.
What are the most recent clinical trials for mesothelioma?
Recent clinical trials for mesothelioma offer hope in the battle against this aggressive form of cancer. One promising trial is exploring a Part B Dose Expansion Combination, which aims to determine the effectiveness and safety of a new treatment approach for mesothelioma patients. Another study focuses on OT-101, investigating its potential benefits as a therapeutic option in mesothelioma cases. Additionally, researchers are evaluating the efficacy and tolerability of dose expansion strategies in solid tumors associated with mesothelioma. In another trial, magnesium sulfate is being investigated as a potential treatment option for managing symptoms related to this challenging disease. Furthermore, SynKIR-110 holds promise as an innovative therapy that could improve outcomes for those affected by mesothelioma. These recent clinical trials provide optimism and may pave the way towards more effective treatments for individuals battling this devastating condition.
What mesothelioma clinical trials were recently completed?
In the quest to combat mesothelioma, several clinical trials have recently concluded, showcasing significant progress in the field. Noteworthy among these is a trial sponsored by the University of Chicago that wrapped up in December 2021, examining the potential of Nivolumab as a treatment option. Another promising study was completed in July 2021 and focused on Magnesium Sulfate under the sponsorship of Dana-Farber Cancer Institute. Additionally, Epizyme, Inc., successfully completed a trial investigating Tazemetostat's efficacy against mesothelioma back in April 2020. These recent advancements highlight ongoing efforts to advance treatments for this challenging disease and offer hope to those affected by it.