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Trials for Adenocarcinoma Patients
Behavioural Intervention
Home-Based Exercise for Prostate Cancer
This trial involves two different exercise programs that can be done at home: one using a stationary exercise bike (Arm A) and the other involving walking (Arm B). The study will include 24 patients
Hormone Therapy
DFMO + Testosterone + Enzalutamide for Prostate Cancer
This trial involves treating patients with advanced prostate cancer that hasn't responded to other treatments. The treatment plan includes taking DFMO, followed by a combination of DFMO and testosterone, and then switching to another medication. These drugs work together to stop cancer cells from growing by blocking important processes they need to survive.
Alkylating agents
Carboplatin vs Olaparib for Prostate Cancer
This trial is comparing the efficacy of two treatments for patients with metastatic castrate resistant prostate cancer who have tumors containing BRCA1, BRCA2 or PALB2 inactivating DNA mutations.
Antiandrogen
Enzalutamide + ADT for Metastatic Prostate Cancer
This trial is testing whether a new drug, enzalutamide, is more effective than a conventional non-steroidal anti androgen (NSAA), when combined with a luteinizing hormone releasing hormone analog (LHRHA) or surgical castration, as first line androgen deprivation therapy (ADT) for newly diagnosed metastatic prostate cancer.
Trials for Prostate Carcinoma Patients
Behavioural Intervention
Home-Based Exercise for Prostate Cancer
This trial involves two different exercise programs that can be done at home: one using a stationary exercise bike (Arm A) and the other involving walking (Arm B). The study will include 24 patients
Hormone Therapy
DFMO + Testosterone + Enzalutamide for Prostate Cancer
This trial involves treating patients with advanced prostate cancer that hasn't responded to other treatments. The treatment plan includes taking DFMO, followed by a combination of DFMO and testosterone, and then switching to another medication. These drugs work together to stop cancer cells from growing by blocking important processes they need to survive.
Alkylating agents
Carboplatin vs Olaparib for Prostate Cancer
This trial is comparing the efficacy of two treatments for patients with metastatic castrate resistant prostate cancer who have tumors containing BRCA1, BRCA2 or PALB2 inactivating DNA mutations.
Antiandrogen
Enzalutamide + ADT for Metastatic Prostate Cancer
This trial is testing whether a new drug, enzalutamide, is more effective than a conventional non-steroidal anti androgen (NSAA), when combined with a luteinizing hormone releasing hormone analog (LHRHA) or surgical castration, as first line androgen deprivation therapy (ADT) for newly diagnosed metastatic prostate cancer.
Trials for Metastatic Patients
Behavioural Intervention
Home-Based Exercise for Prostate Cancer
This trial involves two different exercise programs that can be done at home: one using a stationary exercise bike (Arm A) and the other involving walking (Arm B). The study will include 24 patients
Hormone Therapy
DFMO + Testosterone + Enzalutamide for Prostate Cancer
This trial involves treating patients with advanced prostate cancer that hasn't responded to other treatments. The treatment plan includes taking DFMO, followed by a combination of DFMO and testosterone, and then switching to another medication. These drugs work together to stop cancer cells from growing by blocking important processes they need to survive.
Alkylating agents
Carboplatin vs Olaparib for Prostate Cancer
This trial is comparing the efficacy of two treatments for patients with metastatic castrate resistant prostate cancer who have tumors containing BRCA1, BRCA2 or PALB2 inactivating DNA mutations.
Antiandrogen
Enzalutamide + ADT for Metastatic Prostate Cancer
This trial is testing whether a new drug, enzalutamide, is more effective than a conventional non-steroidal anti androgen (NSAA), when combined with a luteinizing hormone releasing hormone analog (LHRHA) or surgical castration, as first line androgen deprivation therapy (ADT) for newly diagnosed metastatic prostate cancer.
Phase 3 Trials
Antiandrogen
Enzalutamide + ADT for Metastatic Prostate Cancer
This trial is testing whether a new drug, enzalutamide, is more effective than a conventional non-steroidal anti androgen (NSAA), when combined with a luteinizing hormone releasing hormone analog (LHRHA) or surgical castration, as first line androgen deprivation therapy (ADT) for newly diagnosed metastatic prostate cancer.
Hormone Therapy
Androgen Ablation Therapy + Chemotherapy for Prostate Cancer
This trial is studying androgen-ablation therapy and docetaxel to see how well they work compared to androgen-ablation therapy alone in treating patients with metastatic prostate cancer.
Trials With No Placebo
Behavioural Intervention
Home-Based Exercise for Prostate Cancer
This trial involves two different exercise programs that can be done at home: one using a stationary exercise bike (Arm A) and the other involving walking (Arm B). The study will include 24 patients
Hormone Therapy
DFMO + Testosterone + Enzalutamide for Prostate Cancer
This trial involves treating patients with advanced prostate cancer that hasn't responded to other treatments. The treatment plan includes taking DFMO, followed by a combination of DFMO and testosterone, and then switching to another medication. These drugs work together to stop cancer cells from growing by blocking important processes they need to survive.
Alkylating agents
Carboplatin vs Olaparib for Prostate Cancer
This trial is comparing the efficacy of two treatments for patients with metastatic castrate resistant prostate cancer who have tumors containing BRCA1, BRCA2 or PALB2 inactivating DNA mutations.
Antiandrogen
Enzalutamide + ADT for Metastatic Prostate Cancer
This trial is testing whether a new drug, enzalutamide, is more effective than a conventional non-steroidal anti androgen (NSAA), when combined with a luteinizing hormone releasing hormone analog (LHRHA) or surgical castration, as first line androgen deprivation therapy (ADT) for newly diagnosed metastatic prostate cancer.
View More Related Trials
Frequently Asked Questions
Introduction to metastatic prostate cancer
What are the top hospitals conducting metastatic prostate cancer research?
When it comes to advancing the treatment options for metastatic prostate cancer, several hospitals are leading the way. In Fort Collins, Colorado, Poudre Valley Hospital is currently conducting four active clinical trials focused specifically on metastatic prostate cancer. Although they have yet to undertake any previous trials in this area, their commitment to finding new solutions is evident. Similarly, USC/Norris Comprehensive Cancer Center in Los Angeles is actively engaged in four ongoing metastatic prostate cancer trials and has notched up a track record of zero all-time trials dedicated to this form of the disease.
Meanwhile, Arkansas Urology in Little Rock and London Regional Cancer Program in London also prioritize research into metastatic prostate cancer with three active clinical trials each. These institutions have not conducted any prior studies on this specific type of cancer but are determined to make strides forward through their current endeavors. Additionally contributing valuable insights into fighting metastatic prostate cancer is Odette Cancer Centre located in Toronto; they too focus on three active clinical tests while lacking previous background regarding such investigations.
These hospitals' dedication and efforts are crucial as we seek breakthroughs against metastatic prostate cancer—a stage when the disease spreads beyond the prostate gland. By conducting these cutting-edge clinical trials, researchers aim to improve treatment outcomes for patients facing advanced stages of this condition. Their work represents a beacon of hope for those affected by one of the most challenging forms of prostrate cancers worldwide
Which are the best cities for metastatic prostate cancer clinical trials?
When it comes to metastatic prostate cancer clinical trials, several cities stand out as hubs of research and innovation. Los Angeles, California leads the way with 18 active trials focusing on treatments like enzalutamide and Darolutamide+ADT. Sacramento, California follows closely behind with 17 ongoing studies exploring Quality-of-Life Assessment and TAK-700 among others. Denver, Colorado is also a prominent location for these trials, with 16 active studies investigating treatments such as TAK-700 and Niraparib. Tucson, Arizona and San Francisco, California both have 15 active trials each that examine various treatment options including enzalutamide and ADT. These cities provide individuals diagnosed with metastatic prostate cancer access to cutting-edge clinical trials that may lead to advancements in care and improved outcomes.
Which are the top treatments for metastatic prostate cancer being explored in clinical trials?
Metastatic prostate cancer research is at the forefront of medical investigations, with a few promising treatments currently under exploration in clinical trials. Leading the charge is daratumumab, which has shown potential and efficacy in six ongoing trials for metastatic prostate cancer. Another notable contender is belantamab mafodotin, demonstrating promise in four active trials for this aggressive form of cancer. Lastly, lenalidomide's extensive track record of success continues to be evaluated through three ongoing clinical trials specifically focused on metastatic prostate cancer. These innovative treatment options offer hope and progress for patients battling this challenging disease.
What are the most recent clinical trials for metastatic prostate cancer?
Recent clinical trials have brought forth promising advancements in the field of metastatic prostate cancer treatment. One such trial involves [18]F-PSMA-1007 PET/CT or PET/MRI, a diagnostic tool that aims to enhance imaging capabilities for detecting and monitoring the disease. Additionally, investigational treatments are being explored in an effort to improve outcomes for patients with metastatic prostate cancer. These studies focus on innovative medications such as quemliclustatm, etrumadenant, zimberelimab, and SBRT—a combination therapy approach that holds immense potential. Moreover, darolutamide in combination with ADT has shown significant promise as a treatment option through its ongoing Phase 3 trial. With these cutting-edge developments underway, there is renewed hope for individuals facing the challenges of metastatic prostate cancer.
What metastatic prostate cancer clinical trials were recently completed?
Several recent clinical trials have been completed, focusing on metastatic prostate cancer. These studies aim to bring advancements in treatment for this challenging condition. Notably, a trial sponsored by the University of California evaluated the effectiveness of Enzalutamide and was concluded in October 2021. Additionally, in September 2021, a trial led by Memorial Sloan Kettering Cancer Center focused on the investigational therapy known as Rucaparib. Furthermore, an international study conducted by Pfizer examined the use of Abiraterone acetate and Prednisone which reached completion earlier this year in January 2021. These significant research endeavors contribute to expanding our knowledge and improving outcomes for individuals with metastatic prostate cancer.