Spinal Cord Stimulation for Spinal Cord Injury
This trial looks at how transcutaneous spinal cord stimulation affects exercise endurance & core body temp in people with chronic spinal cord injury. Participants will receive active & sham stimulation during exercise & in a cold room. No long-term benefits expected.
Tilt Table Therapy for Parkinson's Disease with Orthostatic Hypotension
This trial will study how low blood pressure (BP) affects brain function in people with Parkinson's disease (PD), who often experience problems thinking and orthostatic hypotension (OH), i.e., low BP when standing.
Vasopressor
Midodrine vs Abdominal Compression for Orthostatic Hypotension
This trial is testing two interventions for low blood pressure when standing up. It will last for five days total, and screen and test participants at Vanderbilt University Medical Center.
Popular Filters
Trials for Dizziness Patients
Device
Automated Abdominal Binder for Orthostatic Hypotension
This trial is testing a special belt that inflates to help people with low blood pressure when they stand up. It targets patients who have a condition that makes it hard for them to keep their blood pressure stable. The belt works by squeezing the abdomen to help keep blood flowing properly when standing.
Alpha-1 Agonist
Abdominal Compression for Orthostatic Hypotension
This trial will help determine how compression garments help autonomic failure patients with orthostatic hypotension by testing how well they improve blood pressure and tolerance to standing up.
Trials for Dysautonomia Patients
Accelerometer Monitoring for Neurogenic Orthostatic Hypotension
This trial is looking for a more objective way to assess the efficacy of treatments for neurogenic orthostatic hypotension, by using an activity monitor to track how long patients spend in the upright position during a week on placebo and a week on their regular medication.
Device
Automated Abdominal Binder for Orthostatic Hypotension
This trial is testing a special belt that inflates to help people with low blood pressure when they stand up. It targets patients who have a condition that makes it hard for them to keep their blood pressure stable. The belt works by squeezing the abdomen to help keep blood flowing properly when standing.
Alpha-1 Agonist
Abdominal Compression for Orthostatic Hypotension
This trial will help determine how compression garments help autonomic failure patients with orthostatic hypotension by testing how well they improve blood pressure and tolerance to standing up.
Device
CO2 Rebreathing for Orthostatic Hypotension
This trial is testing if using a CO2 rebreather device can reduce symptoms of neurogenic orthostatic hypotension, a condition associated with cardiovascular risk & reduced quality of life. Results will show if the device increases CO2 enough to improve BP.
Trials With No Placebo
Device
CO2 Rebreathing for Orthostatic Hypotension
This trial is testing if using a CO2 rebreather device can reduce symptoms of neurogenic orthostatic hypotension, a condition associated with cardiovascular risk & reduced quality of life. Results will show if the device increases CO2 enough to improve BP.
View More Related Trials
Frequently Asked Questions
Introduction to orthostatic hypotension
What are the top hospitals conducting orthostatic hypotension research?
When it comes to cutting-edge clinical trials in the field of orthostatic hypotension, several hospitals are making significant strides. One standout institution is the Autonomic Dysfunction Center at Vanderbilt University Medical Center in Nashville. With four active trials focused on orthostatic hypotension and a total of four completed studies to date, this center has been dedicated to understanding and treating this condition since their first trial recorded in 2016. Another notable hospital is located at the University of Calgary in Canada's picturesque city of Calgary. This facility currently has three ongoing orthostatic hypotension trials and an impressive history of six past studies, with their earliest recorded trial dating back to 2008.
Meanwhile, Vanderbilt University itself plays a vital role as well, conducting three active orthostatic hypotension trials alongside ten accomplished investigations overall since their pioneering study commenced in 1996—a testament to their dedication over the years. In West Orange, New jersey, the Kessler Foundation focuses on advancing knowledge about this condition through two ongoing clinical trials while having just started its journey with orthostatic hypotension research during2023.Despite being relatively new to the scene Quality Living Inc., based out Omaha is also contributing towards tackling Orthostatic Hypertention as they hold one current investigation upon which they embarked only recently starting from 2021.
These top hospitals exemplify unwavering commitment when it comes to studying and finding solutions for individuals living with orthostatic hypotension—an often debilitating condition that causes low blood pressure upon standing up suddenly or remaining upright for extended periods. Through these collaborative efforts across different locations globally,researchers aim not only provide relief but improve quality life for countless individuals impacted by this medical issue worldwide
Which are the best cities for orthostatic hypotension clinical trials?
When it comes to orthostatic hypotension clinical trials, several cities are at the forefront of research and development. Nashville, Tennessee leads with 8 active trials exploring interventions such as accelerometers, automated abdominal binders, and heating pads. Calgary, Alberta follows closely behind with 3 ongoing studies focused on innovative approaches like sequential gas delivery and targeted epidural spinal stimulation. Lastly, West Orange in New jersey and Omaha in Nebraska each have 2 active trials investigating optimal stimulation for blood pressure response and functional electrical stimulation respectively. These cities provide individuals with orthostatic hypotension access to cutting-edge clinical trials that aim to improve understanding and treatment options for this condition.
Which are the top treatments for orthostatic hypotension being explored in clinical trials?
Researchers are actively exploring various treatments for orthostatic hypotension in clinical trials. Some of the top contenders include:
- Sequential Gas Delivery: This innovative approach is being tested in one active trial and marks a significant development in managing orthostatic hypotension.
- Accelerometer: Another promising treatment, currently under investigation in one ongoing trial, utilizes an accelerometer to aid in addressing orthostatic hypotension.
- Functional electrical stimulation (FES): FES has demonstrated potential as a therapeutic option for this condition and is undergoing evaluation through one active clinical trial.
These cutting-edge interventions hold promise for alleviating the symptoms of orthostatic hypotension and improving patients' quality of life.
What are the most recent clinical trials for orthostatic hypotension?
Recent clinical trials have been investigating potential treatments for orthostatic hypotension, a condition characterized by low blood pressure upon standing. One trial focused on a treatment group specifically targeting orthostatic hypotension patients in Phase 2, offering promise for improved management of the condition. Another study explored the use of an automated abdominal binder to alleviate symptoms, with both Phase 1 and Phase 2 showing encouraging results. Additionally, droxidopa was evaluated in Phase 1 as a potential therapeutic option for orthostatic hypotension. These ongoing trials highlight the dedication towards finding effective interventions to enhance the lives of individuals living with this challenging condition.
What orthostatic hypotension clinical trials were recently completed?
A recent clinical trial investigating orthostatic hypotension has reached a significant milestone, shedding light on potential advancements in its treatment. In December 2020, Brigham and Women's Hospital completed their trial evaluating the effectiveness of [F-18]PBR06. This innovative study serves as an important step forward in understanding and addressing the challenges posed by orthostatic hypotension. These findings offer hope for individuals grappling with this condition and provide valuable insights for future research endeavors aimed at improving patient outcomes.