Popular Trials
Anti-tumor antibiotic
Combination Chemotherapy for Colorectal Cancer
This trial tests a combination of three drugs to treat advanced colorectal cancer. It targets patients whose cancer has spread or cannot be surgically removed. The drugs work together to kill cancer cells, block their growth, and help the immune system fight the cancer. Oxaliplatin is a new drug that has been recently added to initial treatments for advanced colorectal cancer.
Standard Treatment Response for Rectal Cancer
This trial aims to understand how the body reacts to standard treatments for rectal cancer, such as chemoradiation and chemotherapy. Researchers will analyze blood, tissue, and scan results to determine how effective
Popular Filters
Trials for Colorectal Cancer Patients
Educational Videos for Colorectal Cancer
This trial aims to study how to improve the participation of Latinos in cancer clinical trials. They will recruit 60 Spanish-speaking individuals from a church in Chapel Hill. Participants will attend an educational session and watch
Monoclonal Antibodies
Dostarlimab for Rectal Cancer
This trial is testing a drug called dostarlimab on patients with a specific type of rectal cancer who haven't been treated before. The goal is to see if this drug alone can treat the cancer effectively, so patients might avoid more aggressive treatments like chemotherapy, radiation, and surgery. Dostarlimab (Jemperliâ„¢) has been approved in the EU and USA for treating certain types of cancer.
Trials for Colon Cancer Patients
Educational Videos for Colorectal Cancer
This trial aims to study how to improve the participation of Latinos in cancer clinical trials. They will recruit 60 Spanish-speaking individuals from a church in Chapel Hill. Participants will attend an educational session and watch
Anti-metabolites
Radiation Therapy + Fluorouracil for Rectal Cancer
This trial tests if combining radiation therapy with chemotherapy can shrink tumors in patients with stage II or III rectal cancer. The treatment aims to make tumors smaller and easier to remove while protecting normal cells. The study will also look at the timing of treatments and their effects on surgery and recovery.
Trials for Metastatic Patients
TGF-beta Receptor Kinase Inhibitor
Galunisertib + Chemotherapy for Rectal Cancer
This trial is testing a new drug to treat rectal cancer in combination with chemotherapy and radiation. Tissue and blood samples will also be collected to study the effectiveness of the drug and the immune system's response.
CDK4/6 Inhibitor
LY3214996 + Cetuximab / Abemaciclib for Colorectal Cancer
This trial is investigating the side effects and best dosage of LY3214996 when given with cetuximab to treat patients with unresectable and/or metastatic colorectal cancer. Cetuximab is an antibody that may interfere with the ability of tumor cells to grow and spread, while LY3214996 and abemaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Tyrosine Kinase Inhibitor
Regorafenib + Immunotherapy for Colorectal Cancer
This trial is studying regorafenib in combination with ipilimumab and nivolumab to see if it can help to treat patients with colorectal cancer that has spread and is resistant to chemotherapy.
Trials for MSI-H Positive Patients
Monoclonal Antibodies
Dostarlimab for Rectal Cancer
This trial is testing a drug called dostarlimab on patients with a specific type of rectal cancer who haven't been treated before. The goal is to see if this drug alone can treat the cancer effectively, so patients might avoid more aggressive treatments like chemotherapy, radiation, and surgery. Dostarlimab (Jemperliâ„¢) has been approved in the EU and USA for treating certain types of cancer.
Small Molecule Inhibitor
RGX-202-01 Combination Therapy for Colorectal Cancer
This trial is testing a new drug, RGX-202-01, to see if it can shrink tumors in people with gastrointestinal cancer. The study will test different doses of the drug to see what is safe and effective. The study will also test the drug in combination with other drugs that are commonly used to treat gastrointestinal cancer.
Checkpoint Inhibitor
Nivolumab + Ipilimumab for Colorectal Cancer
This trial is testing nivolumab with or without ipilimumab as a treatment for metastatic colorectal cancer in patients with microsatellite instability high or mismatch repair deficiency. The goal is to see if the combination therapy is more effective than nivolumab alone and if either treatment is more effective than chemotherapy.
PARP Inhibitor
Niraparib + Panitumumab for Colorectal Cancer
This trial studies how well niraparib and panitumumab work together in treating patients with advanced colorectal cancer who have already received treatment. Niraparib blocks enzymes needed for cancer growth, while panitumumab helps the immune system attack cancer cells and stops them from spreading. Panitumumab is a fully human monoclonal antibody that targets the epidermal growth factor receptor (EGFR) and is used in the treatment of metastatic colorectal cancer, particularly in patients with wild-type KRAS tumors.
Trials for BRAF Positive Patients
Tyrosine Kinase Inhibitor
Regorafenib + Immunotherapy for Colorectal Cancer
This trial is studying regorafenib in combination with ipilimumab and nivolumab to see if it can help to treat patients with colorectal cancer that has spread and is resistant to chemotherapy.
Monoclonal Antibodies
Encorafenib + Cetuximab + Nivolumab for Colorectal Cancer
This trial is testing a combination of drugs to treat patients with colorectal cancer that has spread and cannot be removed by surgery. The drugs work by blocking enzymes needed for cell growth and by helping the body's immune system attack the cancer.
Tyrosine Kinase Inhibitor
Fruquintinib for Colorectal Cancer
This trial tests fruquintinib, a drug that blocks signals making cancer cells grow, in patients with advanced colorectal cancer who haven't responded to other treatments. Fruquintinib is a drug that blocks signals making cancer cells grow and has shown significant benefits in previous trials for certain types of lung cancer. It aims to find new options for those whose cancer continues to progress despite other treatments.
Phase 3 Trials
Chemotherapy
Chemotherapy + Radiation for Rectal Cancer
This trial is looking at whether a different combination of chemotherapy drugs (FOLFOX) and selective use of radiation therapy is better than the standard 5FUCMT treatment for locally advanced rectal cancer.
Trials With No Placebo
Educational Videos for Colorectal Cancer
This trial aims to study how to improve the participation of Latinos in cancer clinical trials. They will recruit 60 Spanish-speaking individuals from a church in Chapel Hill. Participants will attend an educational session and watch
Monoclonal Antibodies
Dostarlimab for Rectal Cancer
This trial is testing a drug called dostarlimab on patients with a specific type of rectal cancer who haven't been treated before. The goal is to see if this drug alone can treat the cancer effectively, so patients might avoid more aggressive treatments like chemotherapy, radiation, and surgery. Dostarlimab (Jemperliâ„¢) has been approved in the EU and USA for treating certain types of cancer.
TGF-beta Receptor Kinase Inhibitor
Galunisertib + Chemotherapy for Rectal Cancer
This trial is testing a new drug to treat rectal cancer in combination with chemotherapy and radiation. Tissue and blood samples will also be collected to study the effectiveness of the drug and the immune system's response.
View More Related Trials
Frequently Asked Questions
Introduction to rectal cancer
What are the top hospitals conducting rectal cancer research?
When it comes to advancing the treatment options for rectal cancer, several top hospitals across the United States are leading the way. In Houston, M D Anderson Cancer Center is making significant strides with eight active clinical trials dedicated to rectal cancer and a total of 23 completed trials. This pioneering institution initiated its first trial in 2000, demonstrating their longstanding commitment to finding innovative solutions for this disease. Meanwhile, in New york City's Memorial Sloan Kettering Cancer Center, researchers are actively engaged in six ongoing rectal cancer trials while having accomplished 16 previous studies since recording their initial trial back in 1999.
Notably contributing from Arizona's medical landscape is Mayo Clinic located in Scottsdale where alongside treating patients they maintain around six cutting-edge clinical tests concerning rectal cancer which will potentially lead medical professionals towards better understanding of such cases along with previously aiding ten researches; Their interest can be traced back a little over a decade ago when they commenced examining this intricate condition through collaborative investigation all done by engaging various participants under controlled environment.They have come up as prominent contributors focused on vertical advancement of fighting against an ailment like Rectum related cancers
Furthermore adding value to this cause is California’s City of Hope Medical Center situated at Duarte whose committed team showcases continued support through conducting four ongoing investigations specific specifically aimed addressing subjects predominantly falling under domain of treating individuals suffering from diseases confined majorly restricted within these lower gastrointestinal areas ,alongside already conducted thirteen experiments till date starting from year two thousand seven until now.
Lastly but not least Washington University School Of Medicine Located In Saint Louis caters similar objectives.Last but not least,is evident through its contribution via conducting four distinct scientific examinations particularly focusing upon concerns pertaining to ailments rooted ceasing solely limited within these lower parts regionally positioned along digestive tract ;And have achieved notable results so far as stated by numbers showcasing nineteen successful already concluded assignments finalizing after initiating very first one somewhere during early months beginning year two thousand two
These hospitals collectively represent the forefront of medical research and innovation in the quest to combat rectal cancer. Their dedication to clinical trials not only offers hope to individuals affected by this condition but also paves the way for improved treatment options and outcomes on a global scale. Through their tireless efforts, they are advancing our understanding of rectal cancer and working towards finding better solutions that will enhance the lives of patients worldwide
Which are the best cities for rectal cancer clinical trials?
When it comes to rectal cancer clinical trials, several cities show promising progress in research and treatment options. Los Angeles, California leads with 29 active trials focusing on medications like Encorafenib, Pembrolizumab, and Subprotocol C2 for MET exon 14 deletion/mutation. New york, New York follows closely behind with 18 ongoing studies investigating treatments such as Oxaliplatin and Amivantamab for participants with Rectal Adenocarcinoma. Nashville, Tennessee and Houston, Texas both have 16 active trials each exploring fruquintinib plus best supportive care and Cetuximab among other treatment approaches. Lastly, Sacramento, California offers 14 active trials attempting to evaluate the efficacy of Pembrolizumab and 5-Fluorouracil (5-FU). These cities serve as hubs for cutting-edge rectal cancer clinical research that strives to improve patient outcomes through innovative interventions.
Which are the top treatments for rectal cancer being explored in clinical trials?
Rectal cancer research is constantly evolving, with several promising treatments currently being explored in clinical trials. The top contenders in the field include:
- Cetuximab: This drug is being tested in three active trials for rectal cancer. With 14 all-time trials since its introduction in 2004, it shows great potential.
- Pembrolizumab: Another hopeful treatment, pembrolizumab is involved in two ongoing rectal cancer trials and has been part of five all-time studies since 2016.
- Chemotherapy: Widely used as a standard treatment approach, chemotherapy remains an active area of investigation with two current rectal cancer trials and a total of twelve all-time studies conducted since 2012.
- Regorafenib: Also showing promise, regorafenib is participating in two active rectal cancer trials and has been studied in five previous research endeavors starting from 2015.
These treatments offer new avenues for improving outcomes and bringing hope to patients battling rectal cancer.
What are the most recent clinical trials for rectal cancer?
Exciting progress is being made in the field of rectal cancer research, with several recent clinical trials offering hope for improved treatment options. One trial focuses on dose-finding for non-small cell lung cancer (NSCLC) in relation to rectal cancer. Another study explores the combination of pembrolizumab and regorafenib as a potential therapy. Additionally, researchers are investigating the tolerability and effectiveness of TAS-102, oxaliplatin, irinotecan with bevacizumab for rectal cancer patients. Dostarlimab monotherapy and botensilimab/balstilimab therapy also show promise as potential treatments for this challenging disease. These ongoing trials hold significant potential to enhance outcomes and quality of life for individuals affected by rectal cancer.
What rectal cancer clinical trials were recently completed?
Promising strides in rectal cancer research have been made through several recently concluded clinical trials. In July 2018, Klus Pharma Inc.'s A166 trial reached completion, shedding light on new possibilities for treatment. Mayo Clinic's investigation into the Trifluridine/Tipiracil Hydrochloride Combination Agent TAS-102 wrapped up in December 2017, providing valuable insights into its potential efficacy against this type of cancer. Additionally, Wake Forest University Health Sciences' examination of 6,8-bis(benzylthio)octanoic acid came to a close in January 2015. These studies reflect the dedication and ongoing efforts within scientific communities to advance our understanding and management of rectal cancer.