Monoclonal Antibodies
BI 764532 for Small Cell Lung Cancer
This trial is for adults with advanced small-cell lung cancer & neuroendocrine tumours. It tests 2 doses of BI 764532, an antibody-like molecule, to see if it shrinks tumours & is safe & tolerable. Participants visit the study site regularly to monitor safety & record effects.
PLK-1 Inhibitor
Onvansertib for Small Cell Lung Cancer
This trial is testing onvansertib, a drug that blocks an enzyme helping cancer cells grow, in patients with small cell lung cancer who can't use standard chemotherapy. By stopping the cancer cells from repairing themselves, the drug aims to slow down or stop their growth.
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Trials for NSCLC Patients
Photosensitizer
Photodynamic Therapy for Lung Cancer
This trial studies a treatment where a special drug is injected and then activated by a laser to shrink tumors in lung cancer patients whose cancer has spread. The goal is to see if this method can safely reduce tumor size.
Trials for Non-Small Cell Lung Cancer Patients
Photosensitizer
Photodynamic Therapy for Lung Cancer
This trial studies a treatment where a special drug is injected and then activated by a laser to shrink tumors in lung cancer patients whose cancer has spread. The goal is to see if this method can safely reduce tumor size.
Monoclonal Antibodies
SGN-CEACAM5C for Advanced Cancers
This trial is testing a new drug called SGN-CEACAM5C for patients with hard-to-treat solid tumors that have either returned or didn't respond to standard treatments. The drug targets cancer cells and kills them. The study will determine the safe dosage and effectiveness of the drug.
Enzyme Depletion
ADI-PEG 20 + Chemotherapy for Lung Cancer
This trial tests a combination of three drugs to treat lung cancer patients who did not respond to initial treatments. The drugs work by starving the cancer cells and attacking them with chemotherapy.
Trials for Metastatic Patients
Checkpoint Inhibitor
Immunotherapy + Chemotherapy for Small Cell Lung Cancer
This trial tests a new combination of immunotherapy and chemotherapy for patients with advanced lung cancer. The treatment uses two drugs to help the immune system fight cancer, along with standard chemotherapy to kill cancer cells. Researchers hope this new approach will improve survival compared to existing treatments.
PD-1/PD-L1 Inhibitor
Pembrolizumab Combinations for Small Cell Lung Cancer
This trial tests a combination of pembrolizumab and new experimental drugs in patients with advanced lung cancer who did not respond to previous treatments. The goal is to see if this combination is safe and effective. Pembrolizumab helps the immune system attack cancer by blocking a protein that stops immune cells from working. Pembrolizumab has been widely studied and approved for the treatment of various cancers, including lung cancer.
Trials for EGFR Positive Patients
Enzyme Depletion
ADI-PEG 20 + Chemotherapy for Lung Cancer
This trial tests a combination of three drugs to treat lung cancer patients who did not respond to initial treatments. The drugs work by starving the cancer cells and attacking them with chemotherapy.
Trials for ALK Positive Patients
Enzyme Depletion
ADI-PEG 20 + Chemotherapy for Lung Cancer
This trial tests a combination of three drugs to treat lung cancer patients who did not respond to initial treatments. The drugs work by starving the cancer cells and attacking them with chemotherapy.
Tyrosine Kinase Inhibitor
Alectinib vs Crizotinib for Non-Small Cell Lung Cancer
This trial compares two medications, alectinib and crizotinib, for treating a specific type of advanced lung cancer. The patients have not received any prior treatment for their cancer. Both drugs work by blocking a protein that helps the cancer cells grow. Alectinib has shown superior effectiveness and fewer side effects compared to crizotinib in treating this type of lung cancer.
Kinase Inhibitor
Ceritinib + Everolimus for Lung Cancer
This trial is testing the side effects and best dosage of ceritinib and everolimus for treating patients with solid tumors that have spread from the original site. Ceritinib and everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Phase 3 Trials
Checkpoint Inhibitor
Immunotherapy + Chemotherapy for Small Cell Lung Cancer
This trial tests a new combination of immunotherapy and chemotherapy for patients with advanced lung cancer. The treatment uses two drugs to help the immune system fight cancer, along with standard chemotherapy to kill cancer cells. Researchers hope this new approach will improve survival compared to existing treatments.
Alkylating agents
Radiation + Chemotherapy for Small Cell Lung Cancer
This trial is testing different radiation therapy regimens to see which is more effective in treating patients with limited-stage small cell lung cancer when given together with chemotherapy.
Tyrosine Kinase Inhibitor
Osimertinib vs Chemotherapy for Lung Cancer
This trial is studying osimertinib vs platinum-based doublet chemotherapy to see if they are better in treating patients with non-small cell lung cancer whose disease has progressed with previous epidermal growth factor receptor tyrosine kinase inhibitor therapy and whose tumors contain a T790M mutation.
Tyrosine Kinase Inhibitor
Alectinib vs Crizotinib for Non-Small Cell Lung Cancer
This trial compares two medications, alectinib and crizotinib, for treating a specific type of advanced lung cancer. The patients have not received any prior treatment for their cancer. Both drugs work by blocking a protein that helps the cancer cells grow. Alectinib has shown superior effectiveness and fewer side effects compared to crizotinib in treating this type of lung cancer.
Trials With No Placebo
PD-1/PD-L1 Inhibitor
Pembrolizumab Combinations for Small Cell Lung Cancer
This trial tests a combination of pembrolizumab and new experimental drugs in patients with advanced lung cancer who did not respond to previous treatments. The goal is to see if this combination is safe and effective. Pembrolizumab helps the immune system attack cancer by blocking a protein that stops immune cells from working. Pembrolizumab has been widely studied and approved for the treatment of various cancers, including lung cancer.
Photosensitizer
Photodynamic Therapy for Lung Cancer
This trial studies a treatment where a special drug is injected and then activated by a laser to shrink tumors in lung cancer patients whose cancer has spread. The goal is to see if this method can safely reduce tumor size.
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Frequently Asked Questions
Introduction to sclc
What are the top hospitals conducting sclc research?
When it comes to cutting-edge clinical trials in the realm of small cell lung cancer (SCLC), several top hospitals are leading the charge. Memorial Sloan Kettering Cancer Center, located in New york City, is at the forefront with seven active SCLC trials and a total of 23 completed trials dedicated to this aggressive form of lung cancer. Since their first recorded trial in 2007, they have been committed to pushing boundaries and seeking innovative treatment options for patients. Washington University School of Medicine in Saint Louis also deserves recognition, boasting six ongoing SCLC trials and an impressive record of 24 previous trials dating back to their inaugural study in 1992.
Meanwhile, down south at Moffitt Cancer Center in Tampa, researchers are making significant strides as well. With six active SCLC trials and 18 past studies under their belt since initiating their first trial on this condition back in 2008, they demonstrate dedication towards improving patient outcomes. PCR Oncology based in Arroyo Grande may be smaller-scale comparatively but plays a vital role with six current SCLC clinical trials; although they have only conducted five all-time investigations since recording its maiden trial on sclc cases In2007 proving every effort made towards understanding this disease is valuable.
Lastly yet importantly,the Lewis Cancer and Research Pavilion at Saint Joseph's/Candler situatedin Savannah seeks contribution through conducting six ongoing tests which adds over previous nine held experiments tracingback ten years ago till when it started participating from year2008 into such widespread medical research.The efforts by these top hospitals indicate not only progress but hope for those affected by small cell lung cancer worldwide.Through each trial conducted we edge closer toward unravelling mysteries surrounding treatments which ensure brighter future for countless patients suffering from this deadly condition
Which are the best cities for sclc clinical trials?
When it comes to small cell lung cancer (SCLC) clinical trials, several cities stand out as key players in research and development. Anchorage, Alaska leads the pack with 28 active trials focusing on promising treatments such as Pembrolizumab, Erlotinib Hydrochloride, and Cisplatin. Following closely behind is Los Angeles, California with 27 ongoing studies investigating similar interventions like Pembrolizumab and Erlotinib Hydrochloride. Houston, Texas also plays a significant role in SCLC research with 25 active trials exploring innovative approaches such as Local Consolidation Therapy and the NovoTTF-200M device. These cities offer individuals diagnosed with SCLC access to cutting-edge clinical trials that may pave the way for improved treatment options and outcomes.
Which are the top treatments for sclc being explored in clinical trials?
In the realm of small cell lung cancer (SCLC) research, several treatments are currently under investigation in clinical trials. Leading the pack is pembrolizumab, a formidable contender with 10 ongoing trials and a history of 26 all-time SCLC trials since its debut in 2014. Another noteworthy player is durvalumab, making waves with three active trials and an impressive track record of 33 all-time SCLC trials since its introduction in 2016. Additionally, stereotactic radiosurgery has emerged as a newcomer on the scene, showing promise with two active trials and three total SCLC trials recorded since its first listing in 2020. As researchers delve deeper into these potential breakthroughs, new avenues for treating SCLC continue to emerge on the horizon.
What are the most recent clinical trials for sclc?
Promising advancements in the field of small cell lung cancer (SCLC) treatment have emerged through recent clinical trials. One notable trial investigates the efficacy of cemiplimab, a novel therapeutic approach for SCLC patients. This Phase 2 study offers hope for improved outcomes and enhanced quality of life. Additionally, ongoing research focuses on dose-finding strategies in non-small cell lung cancer (NSCLC), aiming to adapt them to benefit individuals with SCLC as well. Furthermore, DB-1311 has shown potential as a treatment option through its dual-phase investigation encompassing both Phase 1 and Phase 2 trials. Another experimental drug, LB2102, is currently being evaluated in a Phase 1 trial for its effectiveness against SCLC. Tocilizumab also presents promise as it undergoes combined Phase 1 and Phase 2 testing towards developing innovative treatment options for this aggressive form of lung cancer. These groundbreaking studies mark significant steps forward in the fight against SCLC and offer renewed optimism to those affected by this disease.
What sclc clinical trials were recently completed?
Several notable clinical trials evaluating treatments for small cell lung cancer (SCLC) have recently concluded, offering valuable insights into potential therapeutic options. In July 2021, BeiGene's trial investigating the effectiveness of Ociperlimab concluded successfully. Another significant trial was completed in March 2021 by EMD Serono Research & Development Institute, Inc., examining the efficacy of Berzosertib. These recent advancements contribute to our understanding and bring hope to patients battling SCLC.