Monoclonal Antibodies
SGN-CEACAM5C for Advanced Cancers
This trial is testing a new drug called SGN-CEACAM5C for patients with hard-to-treat solid tumors that have either returned or didn't respond to standard treatments. The drug targets cancer cells and kills them. The study will determine the safe dosage and effectiveness of the drug.
Monoclonal Antibodies
BI 764532 for Small Cell Lung Cancer
This trial is for adults with advanced small-cell lung cancer & neuroendocrine tumours. It tests 2 doses of BI 764532, an antibody-like molecule, to see if it shrinks tumours & is safe & tolerable. Participants visit the study site regularly to monitor safety & record effects.
PLK-1 Inhibitor
Onvansertib for Small Cell Lung Cancer
This trial is testing onvansertib, a drug that blocks an enzyme helping cancer cells grow, in patients with small cell lung cancer who can't use standard chemotherapy. By stopping the cancer cells from repairing themselves, the drug aims to slow down or stop their growth.
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Trials for NSCLC Patients
Photosensitizer
Photodynamic Therapy for Lung Cancer
This trial studies a treatment where a special drug is injected and then activated by a laser to shrink tumors in lung cancer patients whose cancer has spread. The goal is to see if this method can safely reduce tumor size.
Trials for SCLC Patients
Checkpoint Inhibitor
Immunotherapy + Chemotherapy for Small Cell Lung Cancer
This trial tests a new combination of immunotherapy and chemotherapy for patients with advanced lung cancer. The treatment uses two drugs to help the immune system fight cancer, along with standard chemotherapy to kill cancer cells. Researchers hope this new approach will improve survival compared to existing treatments.
PD-1/PD-L1 Inhibitor
Pembrolizumab Combinations for Small Cell Lung Cancer
This trial tests a combination of pembrolizumab and new experimental drugs in patients with advanced lung cancer who did not respond to previous treatments. The goal is to see if this combination is safe and effective. Pembrolizumab helps the immune system attack cancer by blocking a protein that stops immune cells from working. Pembrolizumab has been widely studied and approved for the treatment of various cancers, including lung cancer.
Photosensitizer
Photodynamic Therapy for Lung Cancer
This trial studies a treatment where a special drug is injected and then activated by a laser to shrink tumors in lung cancer patients whose cancer has spread. The goal is to see if this method can safely reduce tumor size.
Trials for Metastatic Patients
Checkpoint Inhibitor
Immunotherapy + Chemotherapy for Small Cell Lung Cancer
This trial tests a new combination of immunotherapy and chemotherapy for patients with advanced lung cancer. The treatment uses two drugs to help the immune system fight cancer, along with standard chemotherapy to kill cancer cells. Researchers hope this new approach will improve survival compared to existing treatments.
PD-1/PD-L1 Inhibitor
Pembrolizumab Combinations for Small Cell Lung Cancer
This trial tests a combination of pembrolizumab and new experimental drugs in patients with advanced lung cancer who did not respond to previous treatments. The goal is to see if this combination is safe and effective. Pembrolizumab helps the immune system attack cancer by blocking a protein that stops immune cells from working. Pembrolizumab has been widely studied and approved for the treatment of various cancers, including lung cancer.
Trials for ALK Positive Patients
Enzyme Depletion
ADI-PEG 20 + Chemotherapy for Lung Cancer
This trial tests a combination of three drugs to treat lung cancer patients who did not respond to initial treatments. The drugs work by starving the cancer cells and attacking them with chemotherapy.
Checkpoint Inhibitor
Immunotherapy + Radiation for Advanced Lung Cancer
This trial is designed to study whether nivolumab/ipilimumab plus either sequential or concurrent stereotactic body radiotherapy (SBRT) is safe for patients with stage IV non-small cell lung cancer.
Tyrosine Kinase Inhibitor
Crizotinib for Non-Small Cell Lung Cancer
This trial studies crizotinib for patients with stage IB-IIIA NSCLC who have had surgery and have an ALK fusion mutation. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working.
Tyrosine Kinase Inhibitor
Erlotinib for Non-Small Cell Lung Cancer
This trial compares erlotinib hydrochloride to observation in treating patients with resected stage IB-IIIA non-small cell lung cancer. Erlotinib hydrochloride may stop tumor cell growth by blocking enzymes needed for cell growth.
Trials for EGFR Positive Patients
Enzyme Depletion
ADI-PEG 20 + Chemotherapy for Lung Cancer
This trial tests a combination of three drugs to treat lung cancer patients who did not respond to initial treatments. The drugs work by starving the cancer cells and attacking them with chemotherapy.
Checkpoint Inhibitor
Immunotherapy + Radiation for Advanced Lung Cancer
This trial is designed to study whether nivolumab/ipilimumab plus either sequential or concurrent stereotactic body radiotherapy (SBRT) is safe for patients with stage IV non-small cell lung cancer.
Tyrosine Kinase Inhibitor
Erlotinib for Non-Small Cell Lung Cancer
This trial compares erlotinib hydrochloride to observation in treating patients with resected stage IB-IIIA non-small cell lung cancer. Erlotinib hydrochloride may stop tumor cell growth by blocking enzymes needed for cell growth.
Phase 3 Trials
Checkpoint Inhibitor
Immunotherapy + Chemotherapy for Small Cell Lung Cancer
This trial tests a new combination of immunotherapy and chemotherapy for patients with advanced lung cancer. The treatment uses two drugs to help the immune system fight cancer, along with standard chemotherapy to kill cancer cells. Researchers hope this new approach will improve survival compared to existing treatments.
Topoisomerase I inhibitors
Etoposide for Small Cell Lung Cancer
This trial uses Etoposide to treat small cell lung cancer patients. It aims to understand how differences in two specific genes affect treatment success and safety. Researchers study these genes to find links between genetic differences and how patients respond to the drug.
Alkylating agents
Radiation + Chemotherapy for Small Cell Lung Cancer
This trial is testing different radiation therapy regimens to see which is more effective in treating patients with limited-stage small cell lung cancer when given together with chemotherapy.
Immunotherapy for Small Cell Lung Cancer
This trial is testing whether Durvalumab alone or with Tremelimumab can help patients with a specific type of lung cancer who have already had initial treatment. The drugs aim to boost the immune system to fight off any remaining cancer cells. Durvalumab and Tremelimumab are being studied together for their potential to improve cancer treatment outcomes.
Trials With No Placebo
PD-1/PD-L1 Inhibitor
Pembrolizumab Combinations for Small Cell Lung Cancer
This trial tests a combination of pembrolizumab and new experimental drugs in patients with advanced lung cancer who did not respond to previous treatments. The goal is to see if this combination is safe and effective. Pembrolizumab helps the immune system attack cancer by blocking a protein that stops immune cells from working. Pembrolizumab has been widely studied and approved for the treatment of various cancers, including lung cancer.
Photosensitizer
Photodynamic Therapy for Lung Cancer
This trial studies a treatment where a special drug is injected and then activated by a laser to shrink tumors in lung cancer patients whose cancer has spread. The goal is to see if this method can safely reduce tumor size.
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Frequently Asked Questions
Introduction to small cell lung cancer
What are the top hospitals conducting small cell lung cancer research?
Across the United States, top hospitals are leading the charge in clinical trials for small cell lung cancer, a formidable disease that affects many individuals. In Saint Louis, Washington University School of Medicine has emerged as a key player with eight ongoing trials and an impressive track record of 24 completed studies dedicated to this particular form of lung cancer. Their involvement dates back to their first recorded trial in 1992, demonstrating their long-standing commitment to advancing treatment options.
Meanwhile, on the East Coast, Memorial Sloan Kettering Cancer Center in New york is making significant strides with eight active small cell lung cancer trials and an impressive history of 23 previous studies. Notably, their interest in exploring new treatments for this devastating disease began more recently in 2007 but has since grown exponentially.
In Bethesda at the National Institutes of Health Clinical Center, researchers are actively engaged in seven clinical trials focused on small cell lung cancer. Although they have conducted only eight all-time trials thus far - starting their investigation journey relatively recently in 2011 - they showcase dedication and expertise within this specialized field.
The esteemed Dana Farber Cancer Institute located in Boston also plays a crucial role by conducting six active clinical trials centered around small cell lung cancer while having contributed significantly with fifteen past investigations since initiating its exploration into this area back in 2010.
Similarly contributing from Boston's medical landscape is Massachusetts General Hospital which currently boasts five ongoing research projects aimed at unraveling potential breakthroughs for those afflicted by small cell lung cancer; throughout its decade-long journey initiated through first trial marking year2006 till present day,it holds distinguished track-record accomplishing nineteen such experiments
These remarkable institutions symbolize hope and progress within the realm of small cell lung cancer research. As they tirelessly work towards better understanding this complex condition and developing effective therapies through rigorous clinical testing, patients can find solace knowing that these hospitals stand united against one common enemy: bringing us closer to improved outcomes and brighter futures for those battling this devastating disease.
Which are the best cities for small cell lung cancer clinical trials?
When it comes to small cell lung cancer clinical trials, several cities have emerged as prominent centers for research and advancements. Anchorage, Alaska leads the pack with 34 active trials focusing on treatments like High Radiation Dose Therapy, Cisplatin, and Atezolizumab. New york City follows closely behind with 27 ongoing studies investigating PF-07104091 monotherapy dose expansion (ovarian), Radiation Therapy Phase 1b, and more. Boston, Massachusetts also plays a significant role in this field with 25 active trials exploring pembrolizumab, Olaparib, PF-07104091 monotherapy dose expansion (ovarian), among others. Nashville, Tennessee and Saint Louis Missouri also contribute significantly to small cell lung cancer research through their respective active trial efforts. These cities offer individuals battling small cell lung cancer access to cutting-edge clinical trials that pave the way for new treatment options and improved outcomes.
Which are the top treatments for small cell lung cancer being explored in clinical trials?
Small cell lung cancer is a fierce adversary, but the field of clinical trials offers hope for patients. Emerging as top contenders are durvalumab, with an impressive seven ongoing trials and 33 all-time small cell lung cancer trials since its introduction in 2016. Atezolizumab follows closely behind, engaging in five active studies and accumulating 37 all-time trials dedicated to battling this aggressive form of cancer since 2017. Also making waves is nivolumab, participating in four current trials out of a total of 23 ever conducted for small cell lung cancer since its debut in 2014. Not to be overlooked is pembrolizumab, contributing to three ongoing studies and boasting an extensive portfolio of 26 all-time small cell lung cancer trials since first listing also back in 2014. These innovative treatments bring renewed optimism on the horizon for those affected by small cell lung cancer.
What are the most recent clinical trials for small cell lung cancer?
Promising developments in clinical trials offer hope for individuals with small cell lung cancer. The DB-1311 trial, currently in Phase 1 and Phase 2, aims to assess the effectiveness of this treatment specifically designed for small cell lung cancer patients. Another trial combines ADI-PEG, gemcitabine, and docetaxel to evaluate their potential synergy against the disease during its early stages. Additionally, mycophenolate mofetil is being investigated as a potential therapeutic option for those affected by small cell lung cancer. These studies highlight the ongoing efforts to advance treatment options and improve outcomes for individuals battling this challenging form of lung cancer.
What small cell lung cancer clinical trials were recently completed?
Recent advancements in small cell lung cancer research have seen the completion of several significant clinical trials. In July 2021, BeiGene successfully concluded a trial investigating Ociperlimab's potential benefits for patients with this aggressive form of lung cancer. Another noteworthy trial sponsored by EMD Serono Research & Development Institute, Inc., examined the effectiveness of Berzosertib and wrapped up in March 2021. These recent milestones demonstrate ongoing efforts to develop innovative treatments that may improve outcomes for individuals battling small cell lung cancer.