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Trials for Melanoma Patients
Monoclonal Antibodies
Sarilumab + Immunotherapy for Melanoma
This trial tests a combination of drugs, including one usually for arthritis and three for cancer. It targets patients with advanced melanoma that can't be surgically removed. The drugs help the immune system attack the cancer by blocking proteins that help the cancer grow.
Monoclonal Antibodies
Triple Drug Therapy for Melanoma
This trial is testing a combination of three drugs to treat melanoma. The drugs will be given for different lengths of time depending on whether the patient is in the induction or maintenance phase of the trial. The trial will assess the safety and tolerability of the combination and the pharmacodynamic activity of one of the drugs.
Chemotherapy
Ipilimumab + Chemotherapy for Melanoma
This trial will study the safety of combining the drugs ipilimumab and carboplatin/paclitaxel to treat metastatic melanoma. It will also look at whether the combination can help patients and what features of the immune system may predict who will respond to the treatment.
Trials for Metastatic Patients
CAR T-cell Therapy
NK Cell Therapy + Temozolomide for Melanoma with Brain Metastasis
This trial is testing a combination of special immune cells and a cancer drug to treat patients with advanced melanoma that has spread to the brain. The immune cells aim to kill the cancer, and the drug helps stop its growth. A new treatment has shown effectiveness against advanced melanoma and brain involvement.
Monoclonal Antibodies
Sarilumab + Immunotherapy for Melanoma
This trial tests a combination of drugs, including one usually for arthritis and three for cancer. It targets patients with advanced melanoma that can't be surgically removed. The drugs help the immune system attack the cancer by blocking proteins that help the cancer grow.
Monoclonal Antibodies
Triple Drug Therapy for Melanoma
This trial is testing a combination of three drugs to treat melanoma. The drugs will be given for different lengths of time depending on whether the patient is in the induction or maintenance phase of the trial. The trial will assess the safety and tolerability of the combination and the pharmacodynamic activity of one of the drugs.
Chemotherapy
Ipilimumab + Chemotherapy for Melanoma
This trial will study the safety of combining the drugs ipilimumab and carboplatin/paclitaxel to treat metastatic melanoma. It will also look at whether the combination can help patients and what features of the immune system may predict who will respond to the treatment.
Trials With No Placebo
CAR T-cell Therapy
NK Cell Therapy + Temozolomide for Melanoma with Brain Metastasis
This trial is testing a combination of special immune cells and a cancer drug to treat patients with advanced melanoma that has spread to the brain. The immune cells aim to kill the cancer, and the drug helps stop its growth. A new treatment has shown effectiveness against advanced melanoma and brain involvement.
Monoclonal Antibodies
Sarilumab + Immunotherapy for Melanoma
This trial tests a combination of drugs, including one usually for arthritis and three for cancer. It targets patients with advanced melanoma that can't be surgically removed. The drugs help the immune system attack the cancer by blocking proteins that help the cancer grow.
Monoclonal Antibodies
Triple Drug Therapy for Melanoma
This trial is testing a combination of three drugs to treat melanoma. The drugs will be given for different lengths of time depending on whether the patient is in the induction or maintenance phase of the trial. The trial will assess the safety and tolerability of the combination and the pharmacodynamic activity of one of the drugs.
Chemotherapy
Ipilimumab + Chemotherapy for Melanoma
This trial will study the safety of combining the drugs ipilimumab and carboplatin/paclitaxel to treat metastatic melanoma. It will also look at whether the combination can help patients and what features of the immune system may predict who will respond to the treatment.
Frequently Asked Questions
Introduction to stage iv melanoma
What are the top hospitals conducting stage iv melanoma research?
When it comes to finding innovative treatments for stage iv melanoma, several top hospitals are leading the charge. Massachusetts General Hospital in Boston is at the forefront with four active clinical trials dedicated to this advanced form of skin cancer. While they may not have any previous trials specifically focused on stage IV melanoma, their expertise and commitment to groundbreaking research make them a key player in the field. Similarly, Dana Farber Cancer Institute, also located in Boston, is actively conducting three trials for stage IV melanoma. Like Massachusetts General Hospital, they do not have any historical trials solely focused on this disease but their contributions are invaluable nonetheless.
In Canada, the Cross Cancer Institute in Edmonton is making notable strides with three ongoing clinical trials targeting stage IV melanoma. This institution's dedication to advancing treatment options for patients facing this aggressive form of cancer demonstrates its commitment to providing cutting-edge care.
Further south in New york City, NYU Langone Health has two active clinical trials specifically designed for stage IV melanoma patients. As with some of the other hospitals mentioned here, NYU Langone Health does not yet have any historically recorded studies exclusively focusing on this advanced stage; however, their ongoing efforts hold great promise for those seeking new therapeutic options.
Lastly but certainly not leastly,the University of Arkansas for Medical Sciences based out Little Rock has made significant headway as well by initiating two current and just as many previously accomplished experiments - all aimed towards easing medical conditions related with Stage-IV Melanomas
These pioneering institutions showcase a collective commitment among researchers worldwide as they strive towards better understanding and more effective treatments against an often challenging diagnosis like stage IV melanoma. By continuously pushing boundaries through rigorous clinical investigations across multiple locations,international medical communities look forward hopeful that these consolidated endeavors will help transform lives affected by such deadly diseases
Which are the best cities for stage iv melanoma clinical trials?
Boston, Massachusetts, stands as the top city for stage iv melanoma clinical trials. With 14 active studies underway, Boston is at the forefront of research on novel treatments like autologous dendritic cell-tumor fusion vaccine and Nivolumab. Following closely behind is New york, New York, with 7 ongoing trials focusing on treatment options including Nivolumab and Nivolumab/Relatlimab. Des Moines in Iowa offers 6 active trials exploring Ipilimumab among other potential interventions. Los Angeles, California, and Oakland, California both have 5 active trials each investigating promising approaches such as Nivolumab/Relatlimab and Dinaciclib respectively. These cities provide essential opportunities for individuals with stage IV melanoma to participate in cutting-edge clinical research that has the potential to improve outcomes and advance cancer care.
Which are the top treatments for stage iv melanoma being explored in clinical trials?
Clinical trials are at the forefront of exploring innovative treatments for stage iv melanoma. Among the leading contenders in these trials are pembrolizumab, a checkpoint inhibitor that has shown promising results; ipilimumab, an immunotherapy drug that targets specific proteins to enhance the immune response against cancer cells; and targeted therapy using BRAF and MEK inhibitors, which specifically target mutations found in melanomas with BRAF gene alterations. These treatments offer hope for patients battling advanced-stage melanoma and continue to be evaluated in ongoing clinical trials.
What are the most recent clinical trials for stage iv melanoma?
Recent clinical trials offer hope for individuals with stage iv melanoma, a challenging and advanced form of skin cancer. One notable trial investigates the combined treatment of UD TGFbetai NK cells and temozolomide, showcasing potential benefits in early phases. Additionally, another study explores the use of Nivolumab/Relatlimab to target stage IV melanoma tumors effectively. These advancements hold promise in improving outcomes for patients facing this aggressive disease.
What stage iv melanoma clinical trials were recently completed?
Recently completed clinical trials targeting stage iv melanoma have shown promising results, providing hope for those affected by this advanced form of skin cancer. These trials include a study sponsored by the National Cancer Institute (NCI) that examined the efficacy of an experimental immunotherapy treatment called PD-1 inhibitor in September 2021. Another notable trial was conducted by Memorial Sloan Kettering Cancer Center to evaluate the effectiveness of combination therapy involving targeted BRAF and MEK inhibitors, which concluded in July 2021. The completion of these groundbreaking trials signifies significant progress in advancing treatments for stage IV melanoma patients, potentially improving outcomes and quality of life for individuals battling this aggressive disease.