Transcranial Magnetic Stimulation
Accelerated iTBS for Postpartum Depression
This trial tests a new magnetic pulse therapy for women with post-partum depression. The therapy aims to improve mood by stimulating a specific brain area. Researchers are comparing two different treatment schedules to see which is more effective and easier for patients to complete. This therapy has been used for major depression and postpartum depression.
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Trials for Concussion Patients
Behavioural Intervention
LED Therapy for Traumatic Brain Injury
This trial tests if special lights can help people with brain injuries by making their brain cells work better. It aims to improve memory, sleep, and overall quality of life. Previous research has shown that using these lights after a brain injury can protect brain cells.
Anxiolytic
Buspirone for Traumatic Brain Injury Irritability and Aggression
This trial is testing buspirone, a medication usually used for anxiety, to see if it can help reduce irritability and aggression in people who have had a traumatic brain injury. The study involves 74 participants who will receive buspirone. The goal is to see if buspirone can make a positive difference in their behavior by calming the brain. Buspirone is a new anxiolytic agent that has been shown to reduce aggression and anxiety without causing sedation or cognitive side effects.
Trials for Traumatic Brain Injury Patients
Behavioural Intervention
LED Therapy for Traumatic Brain Injury
This trial tests if special lights can help people with brain injuries by making their brain cells work better. It aims to improve memory, sleep, and overall quality of life. Previous research has shown that using these lights after a brain injury can protect brain cells.
Anxiolytic
Buspirone for Traumatic Brain Injury Irritability and Aggression
This trial is testing buspirone, a medication usually used for anxiety, to see if it can help reduce irritability and aggression in people who have had a traumatic brain injury. The study involves 74 participants who will receive buspirone. The goal is to see if buspirone can make a positive difference in their behavior by calming the brain. Buspirone is a new anxiolytic agent that has been shown to reduce aggression and anxiety without causing sedation or cognitive side effects.
Phase 3 Trials
Antibiotic
Rifapentine-Based Regimens for Latent Tuberculosis
This trial is being conducted to compare the safety and effectiveness of a novel short 6-week regimen of daily rifapentine (6wP, experimental arm) with a comparator arm of 12-16 weeks of rifamycin-based treatment (standard of care, control arm) of latent M. tuberculosis infection (LTBI).
Enzyme Replacement Therapy
Cipaglucosidase Alfa + Miglustat for Pompe Disease
This trial will study the safety and effectiveness of Cipaglucosidase Alfa/Miglustat in treating Pompe disease in children who have either received enzyme replacement therapy before or have not.
Growth Hormone Replacement Therapy
Somatropin for Growth Hormone Deficiency and Concussion
This trial is testing if giving extra growth hormone can help improve the quality of life for adults who have low growth hormone levels and mild brain injuries. Growth hormone treatment has been shown to improve quality of life in adults with growth hormone deficiency.
Trials With No Placebo
Antibiotic
Pretomanid for Kidney Failure
This trial is a Phase I, open-label, single dose, sequential group study to compare the safety and pharmacokinetics of pretomanid in subjects with severe renal impairment including those with End Stage Renal Disease (ESRD) not needing dialysis, subjects with mild or moderate renal impairment, and subjects with normal renal function. The primary objective is to evaluate the PK profiles of pretomanid in plasma and urine after a single oral dose of 200 mg in subjects with renal impairment compared to matched healthy controls.
EBUS-TBNA Diagnostic Procedure for Early-Stage Lung Cancer
This trial studies how well using ultrasound and a needle to take lung tissue samples after an imaging scan works in diagnosing early-stage lung cancer. It aims to improve the accuracy of determining the cancer stage in patients being considered for a specific type of radiation therapy.
Cell Transfer Therapy
Cell Therapy + Chemo + TBI for Skin Cancer
This trial is testing whether an experimental treatment for metastatic melanoma, which involves cell therapy, is more effective when given with chemotherapy and total body irradiation, or just with chemotherapy.
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Frequently Asked Questions
Introduction to tb
What are the top hospitals conducting tb research?
While tuberculosis (TB) may not be as commonly discussed as some other diseases, pioneering hospitals are actively engaged in clinical trials to combat this global health threat. In East Hanover, the Kessler Foundation is making strides with four ongoing TB trials. Although they have yet to conduct any previous trials on TB, their dedication and commitment to finding effective treatments are evident. Similarly, the City of Hope Medical Center in Duarte has three active TB trials underway and no prior history of conducting such studies.
The National Institutes of Health Clinical Center in Bethesda has also dedicated its resources to tackle this infectious disease. With three currently active TB trials and a cumulative total of five completed studies since their first recorded trial back in 2011, they continue to contribute valuable knowledge towards understanding and combating TB.
Meanwhile, the Kessler Foundation in West Orange is actively engaged in three ongoing clinical trials for tuberculosis without any past records of conducting similar investigations. Lastly, at the University of Miami in sunny Miami itself focus lies upon two current tb cases under consideration; however without much past evidence found regarding tbs earlier experiments here.
These institutions exemplify both innovation and determination within the medical community's fight against tuberculosis—a serious condition affecting millions worldwide. Through these clinical trials conducted across various locations across the country like East Hanover or Duarte where patients might find themselves supported by cutting-edge research led by healthcare professionals who strive for better outcomes every single day.The collective efforts undertaken by these esteemed hospitals bring hope for advancements that will alleviate suffering caused by this persistent disease
Which are the best cities for tb clinical trials?
When it comes to TB clinical trials, several cities in the United States are at the forefront of research and development. Houston, Texas leads with 8 active trials focusing on a range of treatments such as DRL_RI (Proposed rituximab biosimilar), breast cancer, and Donepezil. Baltimore, Maryland closely follows with 8 ongoing studies exploring interventions like Asundexian and Emetine. Bethesda, Maryland also shows promise with 7 active trials investigating Total Body Irradiation (TBI), Pheripheral blood stem cells, and more. Seattle, Washington contributes to the field with 6 active trials including Bilingual Brain injury Education and outpatient Navigation for Hispanic families. Finally, Portland, Oregon offers its own contributions through ongoing studies on breast cancer and branched chain amino acids. These cities serve as important hubs for TB clinical research in their dedication to finding better treatment options for patients worldwide.
Which are the top treatments for tb being explored in clinical trials?
Clinical trials are actively exploring potential treatments for tuberculosis (TB), with one standout contender leading the pack. MK-7762, also known as TBD09, has emerged as a promising option in the fight against TB. Currently, there is one active trial dedicated to assessing its efficacy and safety. Despite being a newcomer on the scene since 2023, this innovative treatment shows great potential in potentially revolutionizing TB management and improving patient outcomes.
What are the most recent clinical trials for tb?
Recent clinical trials have brought new hope for the treatment of tuberculosis (TB). One notable study is focused on emetine, which has progressed to Phase 2 and Phase 3 trials as a potential therapy for TB. Another trial explores an experimental treatment in its early stages (Phase 1) that aims to address this infectious disease. Additionally, researchers are investigating the use of pregnenolone as a possible intervention for TB, with promising results from Phase 2 trials. These advancements signify significant progress in our understanding and management of this global health issue.
What tb clinical trials were recently completed?
A recent milestone has been reached in tuberculosis (TB) research with the completion of a clinical trial investigating Imatinib, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID). In October 2020, this trial concluded, bringing us closer to potentially improved treatment options for TB. With ongoing efforts like these, researchers are dedicated to combatting this infectious disease and making significant strides towards better outcomes for patients.