Behavioural Intervention
Acoustic + Electrical Stimulation for Tinnitus
This trial is testing if playing sounds through headphones or using small electrical currents in the ear can help people with tinnitus. It targets those whose tinnitus significantly affects their quality of life. The treatment works by trying to interfere with the ringing noise, making it quieter or stopping it. Using small electrical currents has been explored in various studies as a potential treatment for tinnitus, showing mixed results in terms of effectiveness.
Vibroacoustic Stimulation for PTSD
This trial tests if the Apollo wearable device can help people with PTSD maintain improvements in their symptoms after MDMA-assisted psychotherapy by using gentle vibrations to improve mood, energy, and focus. MDMA-assisted psychotherapy has shown effectiveness and acceptable safety in reducing PTSD symptoms.
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Trials for Acoustic Neuroma Patients
Nonsteroidal Anti-inflammatory Drug
Aspirin for Acoustic Neuroma
This trial is testing whether aspirin can slow tumor growth and improve hearing in patients aged 12+ with vestibular schwannomas. Aspirin's anti-inflammatory properties might help achieve these effects. Aspirin has been studied for its potential to protect against certain types of hearing loss and has shown some protective effects in previous studies.
Proton Beam Therapy
Proton Radiation Therapy for Acoustic Neuroma
This trial is testing a new type of radiation called proton radiation to see if it can better target small tumors while sparing normal surrounding tissues. They will deliver the proton radiation using fractionated stereotactic radiotherapy (FSRT) and will monitor long-term hearing preservation and tumor growth.
Trials With No Placebo
Procedure
Nerve Freezing for Postoperative Pain
This trial is testing a new tool called the cryoSPHERE probe that freezes nerves to reduce pain after chest surgery. It aims to help patients who usually need a lot of opioids for pain relief. By freezing the nerves, it blocks pain signals and reduces the need for opioid medications. This technique has been used in various forms for pain management, including post-surgery pain and chronic pain conditions.
Ultrasound + Photoacoustic Imaging for Ovarian Health
This trial is testing a new imaging technique that uses light and sound to help doctors see inside the body. It aims to help high-risk ovarian cancer patients avoid unnecessary surgeries while still detecting cancer early.
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Frequently Asked Questions
Introduction to vestibular schwannoma
What are the top hospitals conducting vestibular schwannoma research?
Cutting-edge hospitals across the United States are making significant strides in clinical trials for vestibular schwannoma, a rare condition affecting the nerves responsible for balance and hearing. In Boston, Massachusetts General Hospital is leading the charge with three ongoing trials focused on this unique tumor. Since their first recorded trial in 2009, they have been at the forefront of research and innovation to better understand and treat vestibular schwannoma. Nearby, at Massachusetts Eye and Ear Infirmary, two active clinical trials are underway as part of their commitment to advancing knowledge surrounding this condition. Remarkably, they started their journey in exploring treatments for vestibular schwannoma only three years ago in 2018.
Beyond Boston's borders lies another hub of groundbreaking research - Salt Lake City's University of Utah. With two ongoing clinical trials dedicated to vestibular schwannoma and a history that dates back to their inaugural trial in 2013, they continue to contribute valuable insights into this complex disease. Meanwhile, Vanderbilt University Medical Center in Nashville joined the ranks more recently with two current studies focusing on vestibular schwannoma since recording its first trial just last year in 2021.
While Specialty Physician Associates located in Bethlehem may not have any completed trials under their belt yet regarding vestibular schwannoma treatment options; nevertheless holds promise through its engagement with two active investigations aimed at expanding our understanding of this condition further.
These esteemed medical institutions serve as beacons of hope for individuals affected by vestibular schwannomas worldwide by offering them access to cutting-edge therapies while helping advance scientific knowledge about these rare tumors that impact quality of life significantly
Which are the best cities for vestibular schwannoma clinical trials?
Baltimore, Maryland; Boston, Massachusetts; and Chicago, Illinois are the top cities for vestibular schwannoma clinical trials. Baltimore leads with 8 active trials focusing on treatments like Ureteroscopy Laser Lithotripsy (URS-LL) with Acoustic Enhancer and Regenerative peripheral nerve interface (RPNI). Boston follows closely behind with 7 ongoing studies investigating interventions such as Aspirin and Chronic Motion-modulated Stimulation. Meanwhile, Chicago has 6 active trials exploring treatments like Active device plus standard of care. These cities offer individuals diagnosed with vestibular schwannoma access to cutting-edge research that may lead to improved treatment options and outcomes.
Which are the top treatments for vestibular schwannoma being explored in clinical trials?
Vestibular schwannoma, a benign tumor affecting the nerves responsible for balance and hearing, is an area of active research. Clinical trials are exploring various treatments to combat this condition. Among them are bevacizumab, which has shown promise in reducing tumor size; stereotactic radiosurgery (SRS), a non-invasive procedure delivering focused radiation; and everolimus, an oral medication that targets tumor growth pathways. These treatments offer hope for patients with vestibular schwannoma by providing alternative therapeutic options beyond surgical intervention.
What are the most recent clinical trials for vestibular schwannoma?
Exciting advancements are being made in the realm of vestibular schwannoma treatment, with recent clinical trials offering promising prospects. One such trial focuses on the utilization of a SAM ultrasound device and diclofenac patch to address this condition. The study is currently in Phase 2, having become available on 6/3/2023. Another investigation explores the same intervention but is in its earlier stages, as it has reached Phase 1 since becoming available on 6/1/2023. Additionally, research involving rapid acoustic pulse (RAP) therapy has progressed to Phase 4 after becoming accessible on both 2/7/2023 and 12/14/2022 respectively. These studies mark significant strides towards enhancing therapeutic approaches for individuals affected by vestibular schwannoma.
What vestibular schwannoma clinical trials were recently completed?
In recent times, several clinical trials investigating vestibular schwannoma have reached completion, presenting significant strides in the field. Notably, a trial sponsored by the National Institute on Deafness and Other Communication Disorders (NIDCD) concluded successfully. The study focused on evaluating novel treatment approaches for this type of tumor. These remarkable advancements highlight the commitment of researchers to advancing our understanding and management of vestibular schwannoma, offering hope for patients grappling with this condition.